17. 多系統萎縮症 Multiple system atrophy Clinical trials / Disease details


臨床試験数 : 119 薬物数 : 138 - (DrugBank : 44) / 標的遺伝子数 : 59 - 標的パスウェイ数 : 111

  
7 trials found
No.TrialIDDate_
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agemin
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PhaseCountries
1NCT02388295
(ClinicalTrials.gov)
April 27, 20159/3/2015AZD3241 PET MSA Trial, Phase 2, Randomized,12 Week Safety and Tolerability Trial With PET in MSA PatientsA 12-Week, Multicenter, Randomized, Parallel-Group Study to Assess the Safety, Tolerability, Pharmacokinetics, Biomarker Effects, Efficacy, and Effect on Microglia Activation, as Measured by Positron Emission Tomography, of AZD3241 in Subjects With Multiple System AtrophyMultiple System Atrophy, MSADrug: AZD3241;Drug: PlaceboAstraZenecaNULLCompleted30 Years80 YearsAll59Phase 2United States;Austria;Finland;France;Italy;Sweden;United Kingdom
2EUCTR2014-004902-13-SE
(EUCTR)
14/04/201502/01/2015Study to assess the effect of AZD3241 in Multiple System AtrophyA 12-Week, Multicenter, Randomized, Parallel-Group Study to Assess the Safety, Tolerability, Pharmacokinetics, Biomarker Effects, Efficacy, and Effect on Microglia Activation, as Measured by Positron Emission Tomography, of AZD3241 in Subjects with Multiple System Atrophy Multiple system atrophy (MSA)
MedDRA version: 18.1;Level: PT;Classification code 10064060;Term: Multiple system atrophy;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10]
Product Name: AZD3241 100mg
Product Code: AZD3241
INN or Proposed INN: Not available
Other descriptive name: IUPAC name: 1-(2-Isopropoxyethyl)-2-thioxo-1,2,3,5-tetrahydro-pyrrolo[3,2-d] pyrimidin-4-one
Product Name: AZD3241 300mg
Product Code: AZD3241
INN or Proposed INN: Not available
Other descriptive name: 1-(2-Isopropoxyethyl)-2-thioxo-1,2,3,5-tetrahydro-pyrrolo[3,2-d] pyrimidin-4-one
AstraZeneca ABNULLNot RecruitingFemale: yes
Male: yes
64Phase 2France;United States;Finland;Austria;Italy;United Kingdom;Sweden
3EUCTR2014-004902-13-GB
(EUCTR)
09/04/201524/12/2014Study to assess the effect of AZD3241 in Multiple System AtrophyA 12-Week, Multicenter, Randomized, Parallel-Group Study to Assess the Safety, Tolerability, Pharmacokinetics, Biomarker Effects, Efficacy, and Effect on Microglia Activation, as Measured by Positron Emission Tomography, of AZD3241 in Subjects with Multiple System Atrophy Multiple system atrophy (MSA)
MedDRA version: 18.1;Level: PT;Classification code 10064060;Term: Multiple system atrophy;System Organ Class: 10029205 - Nervous system disorders ;Therapeutic area: Diseases [C] - Nervous System Diseases [C10]
Product Name: AZD3241 100mg
Product Code: AZD3241
INN or Proposed INN: Not available
Other descriptive name: IUPAC name: 1-(2-Isopropoxyethyl)-2-thioxo-1,2,3,5-tetrahydro-pyrrolo[3,2-d] pyrimidin-4-one
Product Name: AZD3241 300mg
Product Code: AZD3241
INN or Proposed INN: Not available
Other descriptive name: 1-(2-Isopropoxyethyl)-2-thioxo-1,2,3,5-tetrahydro-pyrrolo[3,2-d] pyrimidin-4-one
AstraZeneca ABNULLNot Recruiting Female: yes
Male: yes
64 Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - (Phase 3): no Therapeutic use (Phase 4): noUnited States;Finland;United Kingdom;Sweden
4EUCTR2014-004902-13-FI
(EUCTR)
11/02/201531/12/2014Study to assess the effect of AZD3241 in Multiple System AtrophyA 12-Week, Multicenter, Randomized, Parallel-Group Study to Assess the Safety, Tolerability, Pharmacokinetics, Biomarker Effects, Efficacy, and Effect on Microglia Activation, as Measured by Positron Emission Tomography, of AZD3241 in Subjects with Multiple System Atrophy Multiple system atrophy (MSA)
MedDRA version: 18.1;Level: PT;Classification code 10064060;Term: Multiple system atrophy;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10]
Product Name: AZD3241 100mg
Product Code: AZD3241
INN or Proposed INN: Not available
Other descriptive name: IUPAC name: 1-(2-Isopropoxyethyl)-2-thioxo-1,2,3,5-tetrahydro-pyrrolo[3,2-d] pyrimidin-4-one
Product Name: AZD3241 300mg
Product Code: AZD3241
INN or Proposed INN: Not available
Other descriptive name: 1-(2-Isopropoxyethyl)-2-thioxo-1,2,3,5-tetrahydro-pyrrolo[3,2-d] pyrimidin-4-one
AstraZeneca ABNULLNot RecruitingFemale: yes
Male: yes
64Phase 2United States;France;Finland;Austria;United Kingdom;Italy;Sweden
5EUCTR2009-018157-23-GB
(EUCTR)
30/11/201016/06/2010A Phase IIa, Multi-Centre, Double-Blind, Randomised, Placebo-Controlled, Parallel Group 12-Month Treatment, Adaptive Design Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of AZD3241 in Patients with Multiple System AtrophyA Phase IIa, Multi-Centre, Double-Blind, Randomised, Placebo-Controlled, Parallel Group 12-Month Treatment, Adaptive Design Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of AZD3241 in Patients with Multiple System Atrophy Multiple system atrophy
MedDRA version: 12.1;Level: LLT;Classification code 10064060;Term: Multiple system atrophy
Product Name: AZD3241
Product Code: AZD3241
Product Name: AZD3241
Product Code: AZD3241
AstraZeneca ABNULLNot RecruitingFemale: yes
Male: yes
135Phase 2United Kingdom;Spain;Austria
6EUCTR2009-018157-23-AT
(EUCTR)
11/11/201007/07/2010A Phase IIa, Multi-Centre, Double-Blind, Randomised, Placebo-Controlled, Parallel Group, 12-Month Treatment, Adaptive Design Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of AZD3241 in Patients with Multiple System AtrophyA Phase IIa, Multi-Centre, Double-Blind, Randomised, Placebo-Controlled, Parallel Group, 12-Month Treatment, Adaptive Design Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of AZD3241 in Patients with Multiple System Atrophy Multiple system atrophy
MedDRA version: 12.1;Level: LLT;Classification code 10064060;Term: Multiple system atrophy
Product Name: AZD3241
Product Code: AZD3241
Product Name: AZD3241
Product Code: AZD3241
AstraZeneca ABNULLNot RecruitingFemale: yes
Male: yes
120Phase 2Spain;Austria;United Kingdom
7EUCTR2009-018157-23-ES
(EUCTR)
14/09/201023/06/2010A Phase IIa, Multi-Centre, Double-Blind, Randomised, Placebo-Controlled, Parallel Group 12-Month Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of AZD3241 in Patients with Multiple System AtrophyEstudio de fase IIa, multicéntrico, doble ciego, aleatorizado, controlado con placebo, de gruposparalelos, de 12 meses de duración para evaluar la eficacia, la seguridad, la tolerabilidad y lafarmacocinética de AZD3241 en pacientes con atrofia multisistémicaA Phase IIa, Multi-Centre, Double-Blind, Randomised, Placebo-Controlled, Parallel Group 12-Month Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of AZD3241 in Patients with Multiple System AtrophyEstudio de fase IIa, multicéntrico, doble ciego, aleatorizado, controlado con placebo, de gruposparalelos, de 12 meses de duración para evaluar la eficacia, la seguridad, la tolerabilidad y lafarmacocinética de AZD3241 en pacientes con atrofia multisistémica Multiple system atrophyAtrofia Multisistémica
MedDRA version: 12.1;Level: LLT;Classification code 10064060;Term: Multiple system atrophy
Product Name: AZD3241
Product Code: AZD3241
Product Name: AZD3241
Product Code: AZD3241
AstraZeneca ABNULLNot RecruitingFemale: yes
Male: yes
110Phase 2United Kingdom;Spain;Austria