299. 嚢胞性線維症 Cystic fibrosis Clinical trials / Disease details

臨床試験数 : 1,695 / 薬物数 : 1,527 - (DrugBank : 268) / 標的遺伝子数 : 111 - 標的パスウェイ数 : 174

6 trials found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04039087 (ClinicalTrials.gov)	September 5, 2019	28/7/2019	Sildenafil Exercise: Role of PDE5 Inhibition	Mechanisms of Exercise Intolerance in Cystic Fibrosis: Role of PDE5 Inhibition	Cystic Fibrosis	Drug: Sildenafil 40mg oral capsule;Drug: Placebo Oral capsule	National Jewish Health	Augusta University;Cystic Fibrosis Foundation	Recruiting	9 Years	N/A	All	40	Phase 2/Phase 3	United States
2	NCT02626182 (ClinicalTrials.gov)	December 2015	3/12/2015	Evaluation and Treatment of Pulmonary Vascular Disease in Moderate to Severe CF	Evaluation and Treatment of Pulmonary Vascular Disease in Moderate to Severe Cystic Fibrosis Lung Disease	Cystic Fibrosis	Drug: sildenafil;Drug: placebo	National Jewish Health	NULL	Completed	18 Years	N/A	All	14	Phase 1/Phase 2	United States
3	NCT01132482 (ClinicalTrials.gov)	October 2015	16/4/2010	Effects of Sildenafil on CFTR-dependent Ion Transport Activity	Phase II Study of the Effects of Sildenafil on CFTR-dependent Ion Transport Activity	Cystic Fibrosis	Drug: Sildenafil;Drug: Placebo	National Jewish Health	NULL	Completed	18 Years	N/A	All	19	Phase 2	United States
4	NCT02057458 (ClinicalTrials.gov)	April 2014	4/2/2014	Blood Flow and Vascular Function in Cystic Fibrosis	Role of Blood Flow and Vascular Function on Exercise Capacity in Cystic Fibrosis	Cystic Fibrosis	Drug: Sildenafil (Acute-1 hour);Drug: Sildenafil (Subchronic-4 weeks);Drug: Placebo	Augusta University	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Completed	18 Years	N/A	All	19	Phase 2	United States
5	NCT01194232 (ClinicalTrials.gov)	August 2012	1/9/2010	Sildenafil Trial in Children and Young Adults With CF	Randomized Controlled Study of Sildenafil in Children and Young Adults With Mild to Moderate Cystic Fibrosis Lung Disease	Cystic Fibrosis With Mild to Moderate Lung Disease;CMRI of Lung Perfusion;Lung Perfusion;Lung Vascularization	Drug: Sildenafil	Children's Hospital Medical Center, Cincinnati	NULL	Withdrawn	8 Years	21 Years	Both	0	Phase 1/Phase 2	United States
6	NCT00659529 (ClinicalTrials.gov)	August 2008	14/4/2008	Safety and Efficacy of Sildenafil in Cystic Fibrosis (CF) Lung Disease	The Role of Phosphodiesterase Inhibitors in CF Lung Disease	Cystic Fibrosis	Drug: sildenafil	National Jewish Health	Cystic Fibrosis Foundation	Completed	14 Years	N/A	All	36	Phase 1/Phase 2	United States

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