PYRIMETHAMINE ( DrugBank: Pyrimethamine )
4 diseases
告示番号 | 疾患名(ページ内リンク) | 臨床試験数 |
---|---|---|
2 | 筋萎縮性側索硬化症 | 2 |
4 | 原発性側索硬化症 | 1 |
19 | ライソゾーム病 | 2 |
65 | 原発性免疫不全症候群 | 2 |
2. 筋萎縮性側索硬化症
臨床試験数 : 645 / 薬物数 : 589 - (DrugBank : 163) / 標的遺伝子数 : 150 - 標的パスウェイ数 : 225
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | EUCTR2011-004798-99-DE (EUCTR) | 27/02/2013 | 27/12/2012 | Safety and Efficacy of SOD1 Inhibition By Pyrimethamine in Familial (ALS) | Safety and Efficacy of SOD1 Inhibition By Pyrimethamine in Familial (ALS) - Pyrimethamine In Familial ALS | Familial amyotrophic lateral sclerosis (FALS) MedDRA version: 14.1;Level: LLT;Classification code 10036704;Term: Primary lateral sclerosis;System Organ Class: 100000004852;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Trade Name: Daraprim INN or Proposed INN: PYRIMETHAMINE | Weill Medical College of Cornell University | NULL | Not Recruiting | Female: yes Male: yes | 40 | United States;Germany;Italy | |||
2 | NCT01083667 (ClinicalTrials.gov) | November 2009 | 17/12/2009 | SOD1 Inhibition by Pyrimethamine in Familial Amyotrophic Lateral Sclerosis (ALS) | Phase I/II Study of SOD1 Inhibition by Pyrimethamine in Familial ALS | Familial Amyotrophic Lateral Sclerosis | Drug: Pyrimethamine | Weill Medical College of Cornell University | Muscular Dystrophy Association | Completed | 18 Years | N/A | All | 32 | Phase 1/Phase 2 | United States;Germany;Italy;Sweden |
4. 原発性側索硬化症
臨床試験数 : 5 / 薬物数 : 13 - (DrugBank : 6) / 標的遺伝子数 : 13 - 標的パスウェイ数 : 25
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | EUCTR2011-004798-99-DE (EUCTR) | 27/02/2013 | 27/12/2012 | Safety and Efficacy of SOD1 Inhibition By Pyrimethamine in Familial (ALS) | Safety and Efficacy of SOD1 Inhibition By Pyrimethamine in Familial (ALS) - Pyrimethamine In Familial ALS | Familial amyotrophic lateral sclerosis (FALS) MedDRA version: 14.1;Level: LLT;Classification code 10036704;Term: Primary lateral sclerosis;System Organ Class: 100000004852;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Trade Name: Daraprim INN or Proposed INN: PYRIMETHAMINE | Weill Medical College of Cornell University | NULL | Not Recruiting | Female: yes Male: yes | 40 | United States;Germany;Italy |
19. ライソゾーム病
臨床試験数 : 899 / 薬物数 : 684 - (DrugBank : 99) / 標的遺伝子数 : 51 - 標的パスウェイ数 : 182
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | NCT01102686 (ClinicalTrials.gov) | August 2009 | 16/10/2009 | Pyrimethamine as a Treatment for Late-Onset GM2-gangliosidosis (Tay-Sachs and Sandhoff Disease) | Proposed Investigator-Initiated Clinical Trial of Pyrimethamine as a Treatment for Late-Onset GM2-gangliosidosis (Tay-Sachs and Sandhoff Disease) | Gangliosidoses, GM2;Sandhoff Disease;Tay-Sachs Disease | Drug: Pyrimethamine;Drug: Leucovorin | The Hospital for Sick Children | NULL | Completed | 17 Years | N/A | Both | 20 | Phase 1/Phase 2 | Canada |
2 | NCT00679744 (ClinicalTrials.gov) | May 2008 | 15/5/2008 | A Phase I Study of Pyrimethamine in Patients With GM2 Gangliosidosis | A Dose-Escalated, Double-Blind, Placebo-Controlled, Randomized Phase I Clinical Trial of Pyrimethamine in Patients Affected With Chronic GM2 Gangliosidosis (Tay-Sachs or Sandhoff Variants) | G(M2) Ganglioside;Tay-Sachs Disease Ganglioside;Sandhoff Disease Ganglioside | Drug: Pyrimethamine | Exsar Corporation | University Hospital Case Medical Center;New York University School of Medicine;The Hospital for Sick Children | Withdrawn | 18 Years | N/A | Both | 0 | Phase 1 | United States;Canada |
65. 原発性免疫不全症候群
臨床試験数 : 500 / 薬物数 : 614 - (DrugBank : 119) / 標的遺伝子数 : 92 - 標的パスウェイ数 : 217
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | NCT00065390 (ClinicalTrials.gov) | July 2003 | 21/7/2003 | Pyrimethamine to Treat Autoimmune Lymphoproliferative Syndrome | Pilot (Phase I-II) Study of Pyrimethamine (Daraprim) for the Treatment of the Autoimmune Lymphoproliferative Syndrome (ALPS) | Autoimmune Disease;Lymphatic Disease;Lymphoproliferative Disorder | Drug: Pyrimethamine | National Institute of Allergy and Infectious Diseases (NIAID) | NULL | Completed | N/A | N/A | Both | 8 | Phase 1 | United States |
2 | NCT00013689 (ClinicalTrials.gov) | March 2001 | 28/3/2001 | Pyrimethamine and Sulfadoxine for Treatment of Autoimmune Lymphoproliferative Syndrome | Pilot Study of Pyrimethamine and Sulfadoxine (Fansidar) for the Treatment of Individuals With the Autoimmune Lymphoproliferative Syndrome (ALPS) | Autoimmune Disease;Lymphoproliferative Disorder | Drug: Fansidar (pyrimethamine and sulfadoxine) | National Institute of Allergy and Infectious Diseases (NIAID) | NULL | Completed | N/A | N/A | Both | 8 | Phase 1 | United States |