MEMANTINE HYDROCHLORIDE ( DrugBank: Memantine )

3 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
2	筋萎縮性側索硬化症	2
6	パーキンソン病	5
127	前頭側頭葉変性症	1

2. 筋萎縮性側索硬化症

臨床試験数 : 645 / 薬物数 : 589 - (DrugBank : 163) / 標的遺伝子数 : 150 - 標的パスウェイ数 : 225

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04302870 (ClinicalTrials.gov)	February 27, 2020	4/3/2020	Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial	Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial	Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Drug: Memantine Hydrochloride Oral Solution;Drug: Trazodone Hydrochloride oral solution;Drug: Placebo oral solution	University of Edinburgh	University College, London;University of Warwick;NHS Lothian	Recruiting	18 Years	N/A	All	750	Phase 2/Phase 3	United Kingdom
2	EUCTR2007-002117-39-ES (EUCTR)	31/01/2008	12/02/2008	MEMANTINA (Ebixa X) PARA LA DISCAPACIDAD FUNCIONAL EN LA ESCLEROSIS LATERAL AMIOTRÓFICAMEMANTINE (Ebixa R) FOR FUNCTIONAL DISABILITY IN AMYOTROPHIC LATERAL SCLEROSIS . - MEDALS	MEMANTINA (Ebixa X) PARA LA DISCAPACIDAD FUNCIONAL EN LA ESCLEROSIS LATERAL AMIOTRÓFICAMEMANTINE (Ebixa R) FOR FUNCTIONAL DISABILITY IN AMYOTROPHIC LATERAL SCLEROSIS . - MEDALS	Esclerosis Lateral AmiotroficaAmyotrophic lateral Sclerosis MedDRA version: 9.1;Level: LLT;Classification code 10002026;Term: Amyotrophic lateral sclerosis	Trade Name: EBIXA INN or Proposed INN: MEMANTINE HYDROCHLORIDE	Jorge Matias-Guiu Guia	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	140		Spain

6. パーキンソン病

臨床試験数 : 2,307 / 薬物数 : 2,007 - (DrugBank : 349) / 標的遺伝子数 : 188 - 標的パスウェイ数 : 199

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2005-002038-36-GR (EUCTR)	27/02/2007	09/10/2006	A randomised, double-blind, placebo-controlled, 6-month study of the efficacy and safety of memantine in patients with Parkinson’s disease dementia or dementia with Lewy Bodies	A randomised, double-blind, placebo-controlled, 6-month study of the efficacy and safety of memantine in patients with Parkinson’s disease dementia or dementia with Lewy Bodies	Patients with Parkinson’s disease dementia or dementia with Lewy Bodies MedDRA version: 8.1;Level: LLT;Classification code 10012284;Term: Dementia due to Parkinson's disease	Trade Name: Ebixa Product Name: Ebixa INN or Proposed INN: MEMANTINE HYDROCHLORIDE Trade Name: Ebixa Product Name: Ebixa INN or Proposed INN: MEMANTINE HYDROCHLORIDE	H. Lundbeck A/S	NULL	Not Recruiting	Female: yes Male: yes	200	Phase 3	France;Greece;Spain;Austria;Germany;Italy;United Kingdom
2	EUCTR2005-002038-36-FR (EUCTR)	01/12/2006	24/08/2010	A randomised, double-blind, placebo-controlled, 6-month study of the efficacy and safety of memantine in patients with Parkinson’s disease dementia or dementia with Lewy Bodies	A randomised, double-blind, placebo-controlled, 6-month study of the efficacy and safety of memantine in patients with Parkinson’s disease dementia or dementia with Lewy Bodies	Patients with Parkinson’s disease dementia or dementia with Lewy Bodies	Trade Name: Ebixa Product Name: Ebixa INN or Proposed INN: MEMANTINE HYDROCHLORIDE Trade Name: Ebixa Product Name: Ebixa INN or Proposed INN: MEMANTINE HYDROCHLORIDE Trade Name: Ebixa Product Name: Ebixa INN or Proposed INN: MEMANTINE HYDROCHLORIDE	H. Lundbeck A/S	NULL	Not Recruiting	Female: yes Male: yes	200	Phase 3	France;Greece;Spain;Austria;Germany;Italy;United Kingdom
3	EUCTR2005-002038-36-DE (EUCTR)	29/11/2006	19/01/2007	A randomised, double-blind, placebo-controlled, 6-month study of the efficacy and safety of memantine in patients with Parkinson’s disease dementia or dementia with Lewy Bodies	A randomised, double-blind, placebo-controlled, 6-month study of the efficacy and safety of memantine in patients with Parkinson’s disease dementia or dementia with Lewy Bodies	Patients with Parkinson’s disease dementia or dementia with Lewy Bodies	Trade Name: Ebixa Product Name: Memantine INN or Proposed INN: MEMANTINE HYDROCHLORIDE Product Name: Memantine INN or Proposed INN: MEMANTINE HYDROCHLORIDE Trade Name: Ebixa Product Name: Memantine INN or Proposed INN: MEMANTINE HYDROCHLORIDE Product Name: Memantine INN or Proposed INN: MEMANTINE HYDROCHLORIDE	H. Lundbeck A/S	NULL	Not Recruiting	Female: yes Male: yes	200		United Kingdom;Germany;France;Spain;Italy;Greece;Austria
4	EUCTR2005-002038-36-GB (EUCTR)	31/10/2006	09/10/2006	A randomised, double-blind, placebo-controlled, 6-month study of the efficacy and safety of memantine in patients with Parkinson’s disease dementia or dementia with Lewy Bodies	A randomised, double-blind, placebo-controlled, 6-month study of the efficacy and safety of memantine in patients with Parkinson’s disease dementia or dementia with Lewy Bodies	Patients with Parkinson’s disease dementia or dementia with Lewy Bodies MedDRA version: 8.1;Level: LLT;Classification code 10012284;Term: Dementia due to Parkinson's disease	Trade Name: Ebixa Product Name: Ebixa INN or Proposed INN: MEMANTINE HYDROCHLORIDE Product Code: Lu 00-800 INN or Proposed INN: memantine hydrochloride	H. Lundbeck A/S	NULL	Not Recruiting	Female: yes Male: yes	200	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (Phase 3): no Therapeutic use (Phase 4): yes	France;Greece;Spain;Austria;Germany;Italy;United Kingdom
5	EUCTR2005-002038-36-AT (EUCTR)	22/09/2006	09/10/2006	A randomised, double-blind, placebo-controlled, 6-month study of the efficacy and safety of memantine in patients with Parkinson’s disease dementia or dementia with Lewy Bodies	A randomised, double-blind, placebo-controlled, 6-month study of the efficacy and safety of memantine in patients with Parkinson’s disease dementia or dementia with Lewy Bodies	Patients with Parkinson’s disease dementia or dementia with Lewy Bodies	Trade Name: Ebixa Product Name: Ebixa INN or Proposed INN: MEMANTINE HYDROCHLORIDE Trade Name: Ebixa Product Name: Ebixa INN or Proposed INN: MEMANTINE HYDROCHLORIDE Trade Name: Ebixa Product Name: Ebixa INN or Proposed INN: MEMANTINE HYDROCHLORIDE Trade Name: Ebixa Product Name: Ebixa INN or Proposed INN: MEMANTINE HYDROCHLORIDE	H. Lundbeck A/S	NULL	Not Recruiting	Female: yes Male: yes	200		Germany;United Kingdom;France;Spain;Italy;Greece;Austria

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127. 前頭側頭葉変性症

臨床試験数 : 90 / 薬物数 : 87 - (DrugBank : 30) / 標的遺伝子数 : 39 - 標的パスウェイ数 : 88

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00594737 (ClinicalTrials.gov)	October 2007	7/1/2008	Open Label Pilot Study of the Effects of Memantine on FDG-PET in Frontotemporal Dementia	An Open Label Pilot Study of the Effects of Memantine Administration on FDG-PET in Frontotemporal Dementia	Frontotemporal Dementia	Drug: memantine hydrochloride	Tiffany Chow, MD	H. Lundbeck A/S	Completed	40 Years	80 Years	Both	17	Phase 3	Canada

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