Nicotinamide Riboside ( DrugBank: Nicotinamide, Nicotinamide riboside )


5 diseases
告示番号疾患名(ページ内リンク)臨床試験数
2筋萎縮性側索硬化症1
6パーキンソン病3
18脊髄小脳変性症(多系統萎縮症を除く。)1
97潰瘍性大腸炎1
191ウェルナー症候群1

2. 筋萎縮性側索硬化症


臨床試験数 : 645 薬物数 : 589 - (DrugBank : 163) / 標的遺伝子数 : 150 - 標的パスウェイ数 : 225
No.TrialIDDate_
enrollment
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registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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agemin
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PhaseCountries
1NCT04562831
(ClinicalTrials.gov)
October 7, 202010/9/2020The NO-ALS Study: A Trial of Nicotinamide/Pterostilbene Supplement in ALS.A Randomized Placebo-controlled Trial of Nicotinamide/Pterostilbene Supplement in ALS: The NO-ALS StudyAmyotrophic Lateral SclerosisDietary Supplement: EH301 (Nicotinamide Riboside/Pterostilbene)Haukeland University HospitalElysium HealthRecruiting35 YearsN/AAll380N/ANorway

6. パーキンソン病


臨床試験数 : 2,307 薬物数 : 2,007 - (DrugBank : 349) / 標的遺伝子数 : 188 - 標的パスウェイ数 : 199
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
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Inclusion_
agemin
Inclusion_
agemax
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gender
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size
PhaseCountries
1NCT05589766
(ClinicalTrials.gov)
November 28, 202213/10/2022N-DOSE: A Dose Optimization Trial of Nicotinamide Riboside in Parkinson's DiseaseN-DOSE: A Dose Optimization Trial of Nicotinamide Riboside in Parkinson's DiseaseParkinson DiseaseDietary Supplement: Nicotinamide Riboside;Other: PlaceboHaukeland University HospitalNULLRecruiting40 Months100 YearsAll80N/ANorway
2NCT03568968
(ClinicalTrials.gov)
May 15, 202014/6/2018A Randomized Controlled Trial of Nicotinamide Supplementation in Early Parkinson's DiseaseA Randomized Controlled Trial of Nicotinamide Supplementation in Early Parkinson's Disease: the NOPARK StudyParkinson DiseaseDietary Supplement: Nicotinamide Riboside;Drug: PlaceboHaukeland University HospitalNULLRecruiting18 YearsN/AAll400N/ANorway
3NCT03816020
(ClinicalTrials.gov)
March 9, 20197/12/2018NAD-supplementation in Drug naïve Parkinson's DiseaseNAD-PARK: A Double-blinded Randomized Pilot Trial of NAD-supplementation in Drug naïve Parkinson's DiseaseParkinson Disease;Neurodegenerative DiseasesDietary Supplement: Nicotinamide Riboside;Other: PlaceboHaukeland University HospitalNULLCompleted18 YearsN/AAll30N/ANorway

18. 脊髄小脳変性症(多系統萎縮症を除く。)


臨床試験数 : 76 薬物数 : 98 - (DrugBank : 31) / 標的遺伝子数 : 44 - 標的パスウェイ数 : 65
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT04192136
(ClinicalTrials.gov)
September 3, 20206/12/2019NAD+ and Exercise in FANAD+ Precursor Supplementation With Exercise Training to Increase Aerobic Capacity in Friedreich's AtaxiaFriedreich Ataxia 1Dietary Supplement: Nicotinamide Riboside;Dietary Supplement: Placebo;Other: Exercise InterventionChildren's Hospital of PhiladelphiaNational Heart, Lung, and Blood Institute (NHLBI)Recruiting10 Years40 YearsAll72N/AUnited States

97. 潰瘍性大腸炎


臨床試験数 : 2,630 薬物数 : 1,459 - (DrugBank : 265) / 標的遺伝子数 : 144 - 標的パスウェイ数 : 202
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT05561738
(ClinicalTrials.gov)
January 1, 202313/9/2022Nicotinamide Riboside in Ulcerative ColitisNicotinamide Riboside in Ulcerative ColitisUlcerative ColitisDietary Supplement: Nicotinamide Riboside Chloride;Dietary Supplement: Placebo;Other: Standard of CareUniversity of PittsburghCrohn's and Colitis FoundationNot yet recruitingN/A18 YearsAll40N/AUnited States

191. ウェルナー症候群


臨床試験数 : 3 薬物数 : 4 - (DrugBank : 3) / 標的遺伝子数 : 0 - 標的パスウェイ数 : 0
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1JPRN-jRCTs031190141
19/03/202127/11/2019Cross-over trial to verify safety and effectiveness of nicotinamide riboside for patients with Werner syndromeProspective, single-center, cross-over trial to verify safety and effectiveness of nicotinamide riboside for patients with Werner syndrome - EMPOWER Werner syndrome
Werner syndrome;C16.320.925 / C18.452.284.960
Subjects ingest oral capsules of NR (nicotinamide riboside) once daily (total daily dose: nicotinamide riboside 1000 mg).Yokote KoutaroNULLRecruiting>= 20age oldNot applicableBoth30Phase 1-2Japan