Mekinist ( DrugBank: - )

2 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
34	神経線維腫症	3
280	巨大動静脈奇形（頚部顔面又は四肢病変）	1

34. 神経線維腫症

臨床試験数 : 133 / 薬物数 : 186 - (DrugBank : 67) / 標的遺伝子数 : 79 - 標的パスウェイ数 : 190

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03975829 (ClinicalTrials.gov)	November 4, 2019	30/5/2019	Pediatric Long-Term Follow-up and Rollover Study	An Open Label, Multi-center Roll-over Study to Assess Long-term Effect in Pediatric Patients Treated ...	Diffuse Astrocytoma;Anaplastic Astrocytoma;Astrocytoma;Oligodendroglioma, Childhood;Anaplastic Oligo ...	Drug: dabrafenib;Drug: trametinib	Novartis Pharmaceuticals	NULL	Recruiting	1 Year	N/A	All	250	Phase 4	United States;Belgium;Canada;Czechia;Denmark;France;Germany;Japan;Netherlands;Russian Federation;Spa ...
2	EUCTR2019-001317-16-NL (EUCTR)	30/10/2019	16/10/2019	The TRAIN study: TRAmetinib In Neurofibromatosis type 1 related symptomatic plexiform neurofibromas	The TRAIN study: TRAmetinib In Neurofibromatosis type 1 related symptomatic plexiform neurofibromas ...	Adult patients (age >17 years) with (mosaic) NF1 with inoperable symptomatic plexiform neurofibromas ...	Trade Name: Mekinist	ErasmusMC	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	30	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - ( ...	Netherlands
3	EUCTR2018-001846-32-SE (EUCTR)	18/09/2018	31/07/2018	Treatment of symptomatic plexiform neurofibromas, a benign tumour associated with the disorder Neuro ...	Treatment of NF1-related plexiform neurofibroma with trametinib; a single arm, open-label trial with ...	NF1-related plexiform neurofibroma;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neon ...	Trade Name: Mekinist Product Name: Mekinist	VO Barnmedicin, Skånes University Hospital	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	15	Phase 2	Sweden

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280. 巨大動静脈奇形（頚部顔面又は四肢病変）

臨床試験数 : 27 / 薬物数 : 30 - (DrugBank : 15) / 標的遺伝子数 : 14 - 標的パスウェイ数 : 153

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2019-003573-26-BE (EUCTR)		18/12/2019	Evaluating the safety and efficacy of Trametinib in Arterio-Venous Malformations that are refractory ...	Monocentric pilot trial evaluating efficacy of Trametinib in Arteriovenous Malformations that are re ...	Arteriovenous Malformations that are refractory to standard treatments or for which standard treatme ...	Trade Name: Mekinist Product Name: Mekinist	Cliniques universitaires Saint-Luc	NULL	NA			Female: yes Male: yes	20	Phase 2	Belgium

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