METHIONINE ( DrugBank: Methionine )

6 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
34	神経線維腫症	1
84	サルコイドーシス	2
93	原発性胆汁性胆管炎	2
229	肺胞蛋白症（自己免疫性又は先天性）	1
298	遺伝性膵炎	1
300	IgG4関連疾患	1

34. 神経線維腫症

臨床試験数 : 133 / 薬物数 : 186 - (DrugBank : 67) / 標的遺伝子数 : 79 - 標的パスウェイ数 : 190

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2010-019759-23-GB (EUCTR)	12/01/2011	13/12/2010	Evaluation of [11C]-methionine positron emission computerised tomography (PET CT) in diagnosing neurofibromatosis 1(NF1) - malignant peripheral nerve sheath tumours (MPNST) - Methionine PET	Evaluation of [11C]-methionine positron emission computerised tomography (PET CT) in diagnosing neurofibromatosis 1(NF1) - malignant peripheral nerve sheath tumours (MPNST) - Methionine PET	The diagnosis of malignant peripheral nerve sheath tumours in patients with neurofibromatosis 1 MedDRA version: 12;Level: LLT;Classification code 10029268;Term: Neurofibromatosis 1 associated malignant peripheral nerve sheath tumour	Product Name: [11C]-methionine INN or Proposed INN: 2-amino-4-(methyl[11C]sulfanyl)butanoic acid Other descriptive name: Methionine	Guys' and St. Thomas' NHS Foundation Trust	NULL	Not Recruiting			Female: yes Male: yes			United Kingdom

84. サルコイドーシス

臨床試験数 : 149 / 薬物数 : 202 - (DrugBank : 78) / 標的遺伝子数 : 66 - 標的パスウェイ数 : 169

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02824419 (ClinicalTrials.gov)	May 2016	27/5/2016	Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary Sarcoidosis	Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary Sarcoidosis	Pulmonary Sarcoidosis	Drug: Methionine;Drug: DOTANOC	Turku University Hospital	NULL	Recruiting	18 Years	N/A	Both	10	Phase 2/Phase 3	Finland
2	EUCTR2015-001815-11-FI (EUCTR)	19/04/2016	29/12/2015	PET imaging of pulmonary sarcoidosis	Imaging of active granulomas with [18F]FDG and selected inflammatory PET tracers in pulmonary sarcoidosis	Pulmonary sarcoidosis with active garnulomas in the lungs. The diagnosis is based on the clinical evidence or biopsy. MedDRA version: 18.1;Level: PT;Classification code 10037430;Term: Pulmonary sarcoidosis;System Organ Class: 10038738 - Respiratory, thoracic and mediastinal disorders;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Diagnosis [E01]	Product Name: 18F-fluorodeoxyglucose Product Code: FDG INN or Proposed INN: FLUORINE (18F) FLUDEOXYGLUCOSE Product Name: C11-methionine INN or Proposed INN: L-methionine Other descriptive name: L-METHIONINE ([11C]METHYL) Product Name: 68Ga-DOTANOC INN or Proposed INN: DOTANOC Other descriptive name: DOTANOC	Turku PET Centre	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes			Finland

93. 原発性胆汁性胆管炎

臨床試験数 : 298 / 薬物数 : 252 - (DrugBank : 59) / 標的遺伝子数 : 35 - 標的パスウェイ数 : 115

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02557360 (ClinicalTrials.gov)	November 2015	21/9/2015	Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis	Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis	Primary Biliary Cirrhosis	Dietary Supplement: S-adenosyl-L-methionine	Pomeranian Medical University Szczecin	Laval University	Completed	N/A	N/A	All	24	Phase 4	Poland
2	NCT00125281 (ClinicalTrials.gov)	July 25, 2005	29/7/2005	SAMe to Treat Biliary Cirrhosis Symptoms	S-Adenosyl Methionine for Symptomatic Treatment of Primary Biliary Cirrhosis	Liver Cirrhosis, Biliary	Drug: S-adenosyl-methionine (SAMe) capsules	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	NULL	Terminated	21 Years	N/A	All	50	Phase 2	United States

229. 肺胞蛋白症（自己免疫性又は先天性）

臨床試験数 : 44 / 薬物数 : 22 - (DrugBank : 7) / 標的遺伝子数 : 3 - 標的パスウェイ数 : 14

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03887169 (ClinicalTrials.gov)	September 16, 2019	12/3/2019	Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene.	Oral or Enteral Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene.	Pulmonary Alveolar Proteinosis;Mutation Ala393Thr of the MARS Gene;mutationSer567Leu of the MARS Gene	Drug: Methionine;Drug: Vitamin B12, B9, B6, C supplementation;Diagnostic Test: Methionine/homocysteine Dosage;Diagnostic Test: Thoracic CT scan;Diagnostic Test: Abdominal and liver ultrasound.;Diagnostic Test: Brain MRI	Assistance Publique - Hôpitaux de Paris	NULL	Completed	N/A	18 Years	All	3	Phase 1/Phase 2	France

298. 遺伝性膵炎

臨床試験数 : 95 / 薬物数 : 148 - (DrugBank : 51) / 標的遺伝子数 : 53 - 標的パスウェイ数 : 142

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2006-000087-83-GB (EUCTR)	19/12/2008	04/12/2007	EUROPAC2 trial to investigate the efficacy of ANTOX(vers) 1.2 and MGCT (magnesiocard) for the treatment of hereditary pancreatitis and idiopathic chronic pancreatitis. - EUROPAC2	EUROPAC2 trial to investigate the efficacy of ANTOX(vers) 1.2 and MGCT (magnesiocard) for the treatment of hereditary pancreatitis and idiopathic chronic pancreatitis. - EUROPAC2	Hereditary Pancreatitis and Idiopathic Chronic Pancreatitis MedDRA version: 13.1;Level: HLT;Classification code 10033646;Term: Acute and chronic pancreatitis;System Organ Class: 10017947 - Gastrointestinal disorders MedDRA version: 13.1;Level: PT;Classification code 10056976;Term: Hereditary pancreatitis;System Organ Class: 10010331 - Congenital, familial and genetic disorders	Trade Name: Magnesiocard 2.5mmol Other descriptive name: MAGNESIUM ASPARTATE HYDROCHLORIDE Product Name: ANTOX (vers) 1.2 Product Code: ANTOX Other descriptive name: TOCOPHEROL INN or Proposed INN: ASCORBIC ACID Other descriptive name: SELENIUM INN or Proposed INN: METHIONINE	University of Liverpool	The Royal Liverpool and Broadgreen University Hospitals NHS Trust	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	240	Phase 3	United Kingdom

300. IgG4関連疾患

臨床試験数 : 40 / 薬物数 : 47 - (DrugBank : 21) / 標的遺伝子数 : 18 - 標的パスウェイ数 : 141

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-UMIN000019908	2016/01/01	01/01/2016	Preliminary study of [11C]methionine PET/CT in the diagnosis of IgG4 related disease	Preliminary study of [11C]methionine PET/CT in the diagnosis of IgG4 related disease - Preliminary study of [11C]methionine PET/CT in the diagnosis of IgG4 related disease	IgG4 related disease	[11C]methionine PET/CT, [18F]FDG PET/CT	Saitama Medical University International Medical Center	Saitama Medical University Hospital	Complete: follow-up complete	20years-old	Not applicable	Male and Female	30	Not selected	Japan

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