Morphine ( DrugBank: Morphine )

5 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
36	表皮水疱症	1
46	悪性関節リウマチ	6
70	広範脊柱管狭窄症	1
85	特発性間質性肺炎	3
86	肺動脈性肺高血圧症	1

36. 表皮水疱症

臨床試験数 : 163 / 薬物数 : 185 - (DrugBank : 46) / 標的遺伝子数 : 50 - 標的パスウェイ数 : 125

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00231517 (ClinicalTrials.gov)	October 2005	3/10/2005	Randomised Double Blind Placebo Controlled Cross Over Design of the Efficacy of Topical Morphine for Inflammatory Pain in Children With Epidermolysis Bullosa		Epidermylosis Bullosa	Drug: topical opiod;Drug: morphine sulphate in intrasite gel	Institute of Child Health	NULL	Completed	4 Years	18 Years	Both		Phase 4	United Kingdom

46. 悪性関節リウマチ

臨床試験数 : 4,356 / 薬物数 : 2,567 - (DrugBank : 415) / 標的遺伝子数 : 192 - 標的パスウェイ数 : 228

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-UMIN000033059	2018/06/20	20/06/2018	The impact of including corticosteroid in a periarticular injection for pain control after total hip arthroplasty: a double blind randomized controlled trial	The impact of including corticosteroid in a periarticular injection for pain control after total hip arthroplasty: a double blind randomized controlled trial - The impact of including corticosteroid in a periarticular injection for pain control after total hip arthroplasty: a double blind randomized controlled trial	Osteoarthritis of the hip, rheumatoid arthritis, avascular necrosis of the femoral head, femoral neck fracture	A periarticular injection including methylprednisolone, ropivacaine, morphine, bosmin, and ketoprofen for pain after total hip arthroplasty A periarticular injection including ropivacaine, morphine, bosmin, and ketoprofen for pain after total hip arthroplasty	Hokusuikai Kinen Hospital	NULL	Complete: follow-up complete	18years-old	Not applicable	Male and Female	120	Not selected	Japan
2	EUCTR2015-000538-31-DE (EUCTR)	01/06/2015	07/04/2015	Application into the joint of opioids in chronic arthritis of the knee joint	NEUORIMPA - Intraarticular Application of Opioids in Chronic Arthritis of the knee joint - Neuroimpa - knee joint	chronic arthritis of the knee joint effusion as part of spondyloarthritis (Assessments in SpondyloArthritis international Society, ASAS criteria), Rheumatoid Arthritis, RA (according to American Col-lege of Rheumatology, ACR criteria), undifferentiated mono- or oligoarthritis, Osteoarthritis of the knee, OA. MedDRA version: 18.0;Level: LLT;Classification code 10067624;Term: Knee arthritis;System Organ Class: 100000004859;Therapeutic area: Diseases [C] - Musculoskeletal Diseases [C05]	Trade Name: Morphine Hexal INN or Proposed INN: Morphinsulfat Other descriptive name: MORPHINE SULFATE Trade Name: Triam 40 mg Lichtenstein INN or Proposed INN: TRIAMCINOLONACETONID Other descriptive name: TRIAMCINOLONACETONID EP	Charité University medicine Berlin	NULL	Not Recruiting			Female: yes Male: yes		Phase 2	Germany
3	JPRN-UMIN000012257	2013/11/12	11/11/2013	Impact of corticosteroid on periarticular injection for pain control following total knee arthroplasty: a double-blind randomized trial	Impact of corticosteroid on periarticular injection for pain control following total knee arthroplasty: a double-blind randomized trial - Impact of corticosteroid on periarticular injection for pain control following total knee arthroplasty: a double-blind randomized trial	osteoarthritis, rheumatoid arthritis, avascular necrosis of femoral condyle	A periarticular injection including methylprednisolone, ropivacaine, morphine, bosmin, and ketoprofen for pain after total knee arthroplasty A periarticular injection including ropivacaine, morphine, bosmin, and ketoprofen for pain after total knee arthroplasty	Nekoyama Miyao Hospital	NULL	Complete: follow-up complete	18years-old	Not applicable	Male and Female	74	Not selected	Japan
4	JPRN-UMIN000011181	2012/11/19	12/07/2013	Continuous epidural infusion versus periarticular multimodal drug injection in bilateral simultaneous total knee arthroplasty: a randomized controlled trial	Continuous epidural infusion versus periarticular multimodal drug injection in bilateral simultaneous total knee arthroplasty: a randomized controlled trial - Continuous epidural infusion versus periarticular multimodal drug injection in bilateral simultaneous total knee arthroplasty: a randomized controlled trial	Osteoarthritis of knee, rheumatoid arthritis	A continuous epidural infusion containing ropivacaine and morphine for pain after simultaneous bilateral total knee arthroplasty A periarticular multimodal drug injection including ropivacaine, morphine, bosmin, methylprednisolone, and ketoprofen for pain after simultaneous bilateral total knee arthroplasty	Nekoyama miyao hospital	NULL	Complete: follow-up complete	18years-old	Not applicable	Male and Female	60	Not selected	Japan
5	JPRN-UMIN000010902	2012/07/11	07/06/2013	A randomized controlled trial comparing epidural anesthesia and periarticular multimodal drug injection for total knee arthroplasty	A randomized controlled trial comparing epidural anesthesia and periarticular multimodal drug injection for total knee arthroplasty - A randomized controlled trial comparing epidural anesthesia and periarticular multimodal drug injection for total knee arthroplasty	Osteoarthritis of knee, rheumatoid arthritis, avascular necrosis	An epidural anesthesia containing 2mg/ml ropivacaine 100ml and 10mg/ml morphine 0.8ml for pain after total knee arthroplasty A periarticular multimodal drug injection including 7.5mg/ml ropivacaine, 10mg/ml morphine 0.8ml, bosmin 0.3mg, methylprednisolone 40mg, and ketoprofen 50mg for pain after total knee arthroplasty	Nekoyama miyao hospital	NULL	Complete: follow-up complete	18years-old	Not applicable	Male and Female	100	Not selected	Japan
6	NCT00244153 (ClinicalTrials.gov)	June 2004	25/10/2005	Intraarticular Opioids Vs Glucocorticosteroids in Gonarthritis	Intraarticular Application of Opioids Versus Glucocorticosteroids Versus Placebo in Rheumatoid Arthritis	Rheumatic Disease	Drug: intraarticular morphine;Drug: intraarticular dexamethasone	Charite University, Berlin, Germany	NULL	Recruiting	19 Years	N/A	Both	120	Phase 1/Phase 2	Germany

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70. 広範脊柱管狭窄症

臨床試験数 : 95 / 薬物数 : 169 - (DrugBank : 61) / 標的遺伝子数 : 68 - 標的パスウェイ数 : 90

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01275547 (ClinicalTrials.gov)	January 2011	11/1/2011	The Analgesic Effect of Combined Treatment With Intranasal S-ketamine and Intranasal Midazolam	The Analgesic Effect of Combined Treatment With Intranasal S-Ketamine and Intranasal Midazolam Compared With Morphine Patient Controlled Analgesia in Spinal Surgery Patients	Analgesia, Patient-controlled;Spinal Stenosis	Drug: s-ketamine & midazolam;Drug: Morphine PCA	University Hospital, Basel, Switzerland	NULL	Completed	18 Years	N/A	Both	22	Phase 2/Phase 3	Switzerland

85. 特発性間質性肺炎

臨床試験数 : 627 / 薬物数 : 443 - (DrugBank : 120) / 標的遺伝子数 : 99 - 標的パスウェイ数 : 212

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04429516 (ClinicalTrials.gov)	December 17, 2020	12/3/2020	Morphine Sulfate/Placebo for the Treatment of PulmonAry Fibrosis Cough	PAciFy Cough: A Multicentre, Double Blind, Placebo Controlled, Crossover Trial of Morphine Sulfate for the Treatment of PulmonAry Fibrosis Cough	Idiopathic Pulmonary Fibrosis	Drug: Morphine Sulfate;Drug: Placebo oral tablet	Royal Brompton & Harefield NHS Foundation Trust	NULL	Recruiting	40 Years	90 Years	All	44	Phase 3	United Kingdom
2	NCT04497831 (ClinicalTrials.gov)	September 21, 2020	25/7/2020	Morphine for Dyspnea in Pulmonary Fibrosis	Determining the Effectiveness of Nebulized Morphine in Treating Dyspnea in Advanced Idiopathic Pulmonary Fibrosis	Idiopathic Pulmonary Fibrosis (IPF)	Drug: Morphine hydrochloride;Drug: Placebo	Medical University of Gdansk	NULL	Not yet recruiting	18 Years	N/A	All	20	Phase 3	NULL
3	EUCTR2019-003571-19-GB (EUCTR)	21/05/2020	27/02/2020	A multicentre, double blind, placebo controlled, crossover trial of morphine sulphate sulfate for the treatment of PulmonAry Fibrosis Cough (PAciFy Cough Trial)	PAciFy Cough: A multicentre, double blind, placebo controlled, crossover trial of morphine sulfate for the treatment of PulmonAry Fibrosis Cough - PACIFY Cough	Idiopathic pulmonary fibrosis MedDRA version: 21.1;Level: PT;Classification code 10021240;Term: Idiopathic pulmonary fibrosis;System Organ Class: 10038738 - Respiratory, thoracic and mediastinal disorders;Therapeutic area: Diseases [C] - Respiratory Tract Diseases [C08]	Trade Name: Morphine Sulfate Product Name: Morphine Sulfate INN or Proposed INN: morphine sulfate	Royal Brompton and Harefield NHS Foundation Trust	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	44	Phase 3	United Kingdom

86. 肺動脈性肺高血圧症

臨床試験数 : 1,205 / 薬物数 : 684 - (DrugBank : 124) / 標的遺伝子数 : 100 - 標的パスウェイ数 : 193

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03401476 (ClinicalTrials.gov)	May 8, 2017	30/4/2017	Effect of Morphine on Dyspnea and 6-Minute Walk Distance in Pulmonary Arterial Hypertension	Effect of Morphine on Dyspnea and 6-Minute Walk Distance in Pulmonary Arterial Hypertension	Pulmonary Arterial Hypertension	Drug: Morphine Sulfate	John Granton	NULL	Unknown status	18 Years	N/A	All	15	Phase 2	Canada

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