AMITRIPTYLINE ( DrugBank: Amitriptyline )

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4 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
78	下垂体前葉機能低下症	1
97	潰瘍性大腸炎	1
226	間質性膀胱炎（ハンナ型）	2
299	嚢胞性線維症	4

78. 下垂体前葉機能低下症

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臨床試験数 : 492 /  薬物数 : 341 - (DrugBank : 47) / 標的遺伝子数 : 45 - 標的パスウェイ数 : 100

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00497562 (ClinicalTrials.gov)	May 2004	5/7/2007	Growth Hormone as Add-on Treatment in Severe Fibromyalgia With Low IGF-1 Serum Levels (56 Characters)	Exploratory Study to Investigate the Efficacy and Safety of Recombinant Growth Hormone as Add-on Treatment in Patients With Severe Fibromialgia	Fibromyalgia;Growth Hormone Deficiency	Drug: sc recombinant growth hormone + amitriptyline, fluoxetine and tramadol (treated group);Drug: amitriptyline, fluoxetine and tramadol alone (control group)	Centro Medico Teknon	NULL	Completed	18 Years	N/A	Both		Phase 2	Spain

97. 潰瘍性大腸炎

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臨床試験数 : 2,630 /  薬物数 : 1,459 - (DrugBank : 265) / 標的遺伝子数 : 144 - 標的パスウェイ数 : 202

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2019-003220-21-GB (EUCTR)	26/02/2020	12/12/2019	Management of diarrhoea in ulcerative colitis: multi-arm multi stage trial of low FODMAP diet, amitriptyline, ondansetron, or loperamide: MODULATE.	Management of diarrhoea in ulcerative colitis: multi-arm multi-stage trial of low FODMAP diet, amitriptyline, ondansetron, or loperamide: MODULATE. - MODULATE	Diarrhoea in patients with stable ulcerative colitis. MedDRA version: 20.1;Level: LLT;Classification code 10045365;Term: Ulcerative colitis;System Organ Class: 100000004856 MedDRA version: 20.1;Classification code 10033007;Term: Other ulcerative colitis;Classification code 10066557;Term: Chronic diarrhoea;System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]	Trade Name: Amitriptyline Product Name: Amitriptyline INN or Proposed INN: Amitriptyline hydrochloride Product Name: Ondansetron INN or Proposed INN: Ondansetron hydrochloride dihydrate Product Name: Loperamide INN or Proposed INN: loperamide hydrochloride	University of Leeds	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	491	Phase 2;Phase 3	United Kingdom

226. 間質性膀胱炎（ハンナ型）

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臨床試験数 : 145 /  薬物数 : 156 - (DrugBank : 51) / 標的遺伝子数 : 64 - 標的パスウェイ数 : 146

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05658874 (ClinicalTrials.gov)	December 1, 2022	23/11/2022	A Multidisciplinary, Multimodal Bundled Care Approach to Chronic Pelvic Pain	A Multidisciplinary, Multimodal Bundled Care Approach to Chronic Pelvic Pain	Interstitial Cystitis	Drug: Multimodal Bundle Drugs;Procedure: Operative Cystoscopy;Behavioral: Behavioral health consultation/therapy;Other: Pelvic floor physical therapy;Other: Usual Urogynecologic care;Drug: Bladder Instillation;Drug: Vaginal estrogen;Drug: Methenamine;Drug: Amitriptyline/Gabapentin	Jocelyn Fitzgerald	NULL	Recruiting	18 Years	99 Years	Female	80	Phase 3	United States
2	NCT00124306 (ClinicalTrials.gov)	February 2005	13/7/2005	Efficacy of Amitriptyline for Painful Bladder Syndrome (PBS)	A Randomized Multicenter Clinical Trial to Evaluate the Efficacy of Amitriptyline for the Treatment of Painful Bladder Syndrome (PBS) in Newly Diagnosed Patients	Bladder Diseases;Interstitial Cystitis	Drug: Amitriptyline;Other: Placebo	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	University of Pennsylvania	Completed	18 Years	N/A	Both	271	Phase 3	United States;Canada

299. 嚢胞性線維症

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臨床試験数 : 1,695 /  薬物数 : 1,527 - (DrugBank : 268) / 標的遺伝子数 : 111 - 標的パスウェイ数 : 174

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01309178 (ClinicalTrials.gov)	May 2009	4/3/2011	Anti-inflammatory Pulmonal Therapy of Cystic Fibrosis (CF) Patients With Amitriptyline and Placebo	Anti-inflammatory Pulmonal Therapy of CF Patients With Amitriptyline and Placebo - a Randomised, Double-blind, Placebo-controlled, Multicenter, Cohort - Study	Cystic Fibrosis;Pneumonia	Drug: Amitriptyline;Drug: Mannite	University Children’s Hospital Tuebingen	Universität Duisburg-Essen;University of Ulm	Recruiting	14 Years	65 Years	Both	30	Phase 2	Germany
2	EUCTR2006-002259-33-DE (EUCTR)	10/10/2006	11/07/2006	Protocol for a Phase II-studyAnti-inflammatory pulmonal therapy of CF-patients with Amitriptyline and Placebo - a randomised, double-blinded, placebo-controlled, cross over study -	Protocol for a Phase II-studyAnti-inflammatory pulmonal therapy of CF-patients with Amitriptyline and Placebo - a randomised, double-blinded, placebo-controlled, cross over study -	CF-patients develop a chronic pulmonary infection with Pseudomonas aeruginosa (P. aeruginosa). At present it is unknown why CF-patients are highly sensitive to P. aeruginosa infections and, most important, no curative treatment for cystic fibrosis is available. This Study should provide a novel anti-inflammatory treatment for cystic fibrosis, which reduces pulmonary complications, progression of the disease and may possibly increase the life-expectance of the patients.	Trade Name: Amitriptylin-ct Tabletten Product Name: Amitriptyline INN or Proposed INN: AMITRIPTYLINE Trade Name: Amitriptylin-ct Tabletten Product Name: Amitriptyline INN or Proposed INN: AMITRIPTYLINE Trade Name: Amitriptylin-ct Tabletten Product Name: Amitriptyline INN or Proposed INN: AMITRIPTYLINE	Paediatrisches Sekretariat fuer Klinische Studien	NULL	Not Recruiting			Female: yes Male: yes	18	Phase 2	Germany
3	NCT00515229 (ClinicalTrials.gov)	October 2006	9/8/2007	Anti-Inflammatory Pulmonal Therapy of CF-Patients With Amitriptyline and Placebo	Protocol for a Phase II-Study Anti-Inflammatory Pulmonal Therapy of CF-Patients With Amitriptyline and Placebo - Randomised, Double-Blinded, Placebo-Controlled, Cross Over - Study -	Cystic Fibrosis;Infection;Pseudomonas Aeruginosa	Drug: amitriptyline	University Hospital Tuebingen	NULL	Completed	18 Years	50 Years	Both	18	Phase 2	Germany
4	EUCTR2008-002673-13-DE (EUCTR)		27/08/2008	Anti-inflammatory pulmonal therapy of CF-patients with Amitriptyline and Placebo	Anti-inflammatory pulmonal therapy of CF-patients with Amitriptyline and Placebo	Deficiency of the Cftr-molecule results in accumulation of ceramide in respiratory epithelial cells. Ceramide triggers a pro-inflammatory and -apoptotic status in cystic fibrosis patients. Amitriptyline reduces ceramide levels in the lung tissue, normalises the activity of cytokines and prevents constitutive cell death of epithelial cells. Amitriptyline prevents pulmonary infections of CF-mice with P. aeruginosa. Amitriptyline may result in an improved lung function of cystic fibrosis patients.	Trade Name: Amitriptylin-CT Product Name: Amitriptyline INN or Proposed INN: Amitriptyline	PSKS	NULL	Not Recruiting			Female: yes Male: yes		Phase 2	Germany

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