Olaparib ( DrugBank: Olaparib )


2 diseases
告示番号疾患名(ページ内リンク)臨床試験数
86肺動脈性肺高血圧症2
285ファンコニ貧血2

86. 肺動脈性肺高血圧症


臨床試験数 : 1,205 薬物数 : 684 - (DrugBank : 124) / 標的遺伝子数 : 100 - 標的パスウェイ数 : 193
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT03782818
(ClinicalTrials.gov)
November 20, 201917/12/2018Olaparib for PAH: a Multicenter Clinical TrialOlaparib for Pulmonary Arterial Hypertension: a Multicenter Clinical TrialPulmonary Arterial HypertensionDrug: OlaparibLaval UniversityCanadian Institutes of Health Research (CIHR);AstraZenecaRecruiting18 Years75 YearsAll20Phase 1/Phase 2Canada
2NCT03251872
(ClinicalTrials.gov)
October 25, 201813/8/2017Olaparib for PAH: a Pilot StudyOlaparib for Pulmonary Arterial Hypertension: a Pilot Clinical StudyPulmonary Arterial HypertensionDrug: OlaparibLaval UniversityNULLTerminated18 Years75 YearsAll6Early Phase 1Canada

285. ファンコニ貧血


臨床試験数 : 62 薬物数 : 93 - (DrugBank : 30) / 標的遺伝子数 : 30 - 標的パスウェイ数 : 144
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT04483544
(ClinicalTrials.gov)
December 3, 202020/7/2020Pembrolizumab and Olaparib in Cervical Cancer PatientsImmunotherapy in Combination With PARP Inhibition in Advanced Cervical Cancer Patients Functionally Competent or Deficient for the Fanconi Anemia Repair PathwayCervical Cancer;Cervical CarcinomaDrug: pembrolizumab;Drug: olaparibBaptist Health South FloridaFlorida Department of Health;Merck Sharp & Dohme LLCRecruiting18 YearsN/AFemale48Phase 2United States
2NCT04042831
(ClinicalTrials.gov)
June 9, 202029/7/2019Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene MutationsA Phase II Study of Olaparib in Patients With Advanced Biliary Tract Cancer With Aberrant DNA Repair Gene MutationsARID1A Gene Mutation;ATM Gene Mutation;ATR Gene Mutation;Bile Duct Adenocarcinoma;BRCA1 Gene Mutation;BRCA2 Gene Mutation;BRIP1 Gene Mutation;CHEK2 Gene Mutation;EMSY Gene Mutation;Fanconi Anemia Complementation Group Gene Mutation;Metastatic Bile Duct Carcinoma;MRE11 Gene Mutation;NBN Gene Mutation;PALB2 Gene Mutation;PTEN Gene Deletion;RAD51 Gene MutationDrug: OlaparibAcademic and Community Cancer Research UnitedNational Cancer Institute (NCI)Recruiting18 YearsN/AAll36Phase 2United States