Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	PARP2	2件: Base excision repair, Apoptosis	D09730	Olaparib	2件: 86, 285
2	CD52	-	D02802	Alemtuzumab	2件: 285, 326
3	PARP1	5件: Base excision repair, NF-kappa B signaling pathway, Apoptosis, Necroptosis, Diabetic cardiomyopa ...	D09730	Olaparib	2件: 86, 285
4	CSF2RA	4件: Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Hematopoietic cell lineage, ...	D05803	Sargramostim	7件: 6, 28, 60, 62, 96, 229, 285
5	CSF3R	5件: Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, ...	D03235	Filgrastim	35件: 2, 6, 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 6 ...
6	DHFR	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
7	DHFR2	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
8	ESR1	9件: Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone s ...	D00289	Danazol	5件: 60, 63, 64, 65, 285
9	NR3C1	1件: Neuroactive ligand-receptor interaction	D00407	Methylprednisolone	2件: 285, 296
10	IMPDH1	4件: Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism	D00752	Mycophenolate mofetil	34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, ...

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