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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
10.5% marcaine----1件: 70
20.9% saline----2件: 6, 70
30002-8971----1件: 70
41mg/kg/hr TXA intravenous infusion till the last suture----1件: 70
5Acetaminophen1件: Acetaminophen1件: D00217 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬16件: 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
6Acetate1件: Acetate---43件: 1, 2, 6, 10, 13, 35, 40, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 162, 171, 206, 222, 224, 225, 227, 235, 265, 288, 298, 299
7Acupuncture----2件: 46, 70
8Adjunctive analgesics----1件: 70
9Adjunctive anti-depressants----1件: 70
10AK1320 MS----1件: 70
11AlloGen-LI----1件: 70
12Allograft----1件: 70
13Alprostadil1件: Alprostadil2件: D00180 ,
D02705 		1件: PTGER1 💬4件: Calcium signaling pathway, Human cytomegalovirus infection, Neuroactive ligand-receptor interaction, Pathways in cancer 💬2件: 51, 70
14Amino acids1件: Amino acids---3件: 70, 240, 298
15Aminocaproic acid1件: Aminocaproic acid1件: D00160 1件: PLG 💬4件: Complement and coagulation cascades, Influenza A, Neuroactive ligand-receptor interaction, Staphylococcus aureus infection 💬1件: 70
16Amniotic Fluid Allograft----1件: 70
17Apple1件: Apple---1件: 70
18Apple Watch and App1件: Apple---1件: 70
19Bee venom pharmacopuncture----1件: 70
20Bilateral transforaminal epidural steroid injections----1件: 70
21Bioactive Glass-Ceramic Spacer----1件: 70
22Bone Marrow Concentrate----1件: 70
23BOTULINUM TOXIN TYPE A1件: Botulinum toxin type A1件: D00783 1件: SNAP25 💬2件: Insulin secretion, Synaptic vesicle cycle 💬10件: 2, 5, 6, 7, 13, 15, 17, 70, 113, 149
24Botulinum toxin type A (Nabota®) injection into the gastrocnemius muscle1件: Botulinum toxin type A1件: D00783 1件: SNAP25 💬2件: Insulin secretion, Synaptic vesicle cycle 💬1件: 70
25Bupivacaine1件: Bupivacaine2件: D01450 ,
D07552 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬8件: 46, 51, 53, 70, 96, 168, 226, 298
26Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine3件: Bupivacaine,
Clonidine,
Epinephrine		7件: D00095 ,
D00281 ,
D00604 ,
D00996 ,
D01450 ,
D02149 ,
D07552 		14件: ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		16件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Taste transduction, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 70
27Bupivacaïne HCl 0,125% / Sufentanil 50 µg flacon à 50 ml1件: Sufentanil2件: D00845 ,
D05938 		1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬1件: 70
28Buprenorphine1件: Buprenorphine2件: D00836 ,
D07132 		2件: OPRK1,
OPRM1 💬		3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬3件: 46, 70, 298
29Caudal epidural injection----1件: 70
30Caudal Epidural Injection with Celestone----1件: 70
31Caudal Epidural Injection with DepoMedrol----1件: 70
32Caudal Epidural Injection with generic Celestone----1件: 70
33Celebrex 200Mg Capsule----1件: 70
34Celecoxib1件: Celecoxib1件: D00567 1件: PTGS2 💬22件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬10件: 2, 3, 34, 46, 70, 89, 107, 161, 171, 271
35Cervical Orthosis (CO)----1件: 70
36Chuna manipulation----1件: 70
37Chuna manual medicine----1件: 70
38CILOSTAZOL1件: Cilostazol1件: D01896 3件: PDE3A,
PDE3B,
TBXA2R 💬		14件: Apelin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Platelet activation, Progesterone-mediated oocyte maturation, Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 51, 70, 124
39Clonidine1件: Clonidine2件: D00281 ,
D00604 		3件: ADRA2A,
ADRA2B,
ADRA2C 💬		2件: Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬4件: 6, 65, 70, 78
40CO----6件: 6, 13, 53, 70, 85, 149
41Combination Product: Goldic serum----1件: 70
42CONDUIT™ Interbody Platform composed of the EIT (Emerging Implant Technologies) Cellular Titanium®1件: Titanium---1件: 70
43Control group----5件: 2, 34, 46, 70, 235
44Creatinine1件: Creatinine1件: D03600 --4件: 2, 46, 60, 70
45Cupping----1件: 70
46Darvocet----1件: 70
47Decadron Phosphate, Injectable1件: Phosphate ion---1件: 70
48Deksmedetomidiini----1件: 70
49Demineralized Bone Matrix----1件: 70
50DepoMedrol----1件: 70
51Dexamethasone1件: Dexamethasone9件: D00292 ,
D00975 ,
D01510 ,
D01615 ,
D01632 ,
D01948 ,
D02174 ,
D02591 ,
D02592 		1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬25件: 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
52DEXAMETHASONE SODIUM PHOSPHATE2件: Dexamethasone,
Phosphate ion		9件: D00292 ,
D00975 ,
D01510 ,
D01615 ,
D01632 ,
D01948 ,
D02174 ,
D02591 ,
D02592 		1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬3件: 65, 70, 96
53Dexdor1件: Dexmedetomidine2件: D00514 ,
D01205 		3件: ADRA2A,
ADRA2B,
ADRA2C 💬		2件: Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬4件: 2, 4, 6, 70
54DEXMEDETOMIDINE1件: Dexmedetomidine2件: D00514 ,
D01205 		3件: ADRA2A,
ADRA2B,
ADRA2C 💬		2件: Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬13件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
55Dexmedetomidine group1件: Dexmedetomidine2件: D00514 ,
D01205 		3件: ADRA2A,
ADRA2B,
ADRA2C 💬		2件: Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬1件: 70
56DEXMEDETOMIDINE HYDROCHLORIDE1件: Dexmedetomidine2件: D00514 ,
D01205 		3件: ADRA2A,
ADRA2B,
ADRA2C 💬		2件: Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬1件: 70
57Dexmedetomidine with ropivacaine2件: Dexmedetomidine,
Ropivacaine		4件: D00514 ,
D01205 ,
D04048 ,
D08490 		8件: ADRA2A,
ADRA2B,
ADRA2C,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		5件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Neuroactive ligand-receptor interaction, Taste transduction, cGMP-PKG signaling pathway 💬1件: 70
58Dextrose1件: Dextrose, unspecified form---5件: 56, 60, 65, 70, 226
59Diphenhydramine1件: Diphenhydramine6件: D00300 ,
D00669 ,
D02419 ,
D03285 ,
D03360 ,
D03854 		1件: HRH1 💬3件: Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
60EACA1件: Aminocaproic acid1件: D00160 1件: PLG 💬4件: Complement and coagulation cascades, Influenza A, Neuroactive ligand-receptor interaction, Staphylococcus aureus infection 💬1件: 70
61Electroacupuncture----2件: 6, 70
62Epidural injection----1件: 70
63Epidural local anesthetic injection----1件: 70
64Epidural steroid (dexamethasone) injection1件: Dexamethasone9件: D00292 ,
D00975 ,
D01510 ,
D01615 ,
D01632 ,
D01948 ,
D02174 ,
D02591 ,
D02592 		1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬1件: 70
65Epidural Steroid Injection----1件: 70
66Epidural steroid with local anesthetic injection----1件: 70
67Epinephrine1件: Epinephrine3件: D00095 ,
D00996 ,
D02149 		9件: ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬		14件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 46, 70, 96
68Epsilon-Aminocaproic Acid (EACA)1件: Aminocaproic acid1件: D00160 1件: PLG 💬4件: Complement and coagulation cascades, Influenza A, Neuroactive ligand-receptor interaction, Staphylococcus aureus infection 💬1件: 70
69Erector spinae plane block (Group E)----1件: 70
70ERYTHROPOIETIN1件: Erythropoietin1件: D03231 1件: EPOR 💬5件: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬9件: 2, 6, 13, 18, 22, 47, 70, 95, 96
71ESKETAMINE1件: Esketamine1件: D07283 5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬3件: 2, 4, 70
72ESKETAMINE HYDROCHLORIDE1件: Esketamine1件: D07283 5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬1件: 70
73Fentanyl1件: Fentanyl2件: D00320 ,
D01399 		1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬4件: 46, 70, 215, 231
74Forsteo1件: Teriparatide1件: D06078 1件: PTH1R 💬3件: Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬3件: 70, 235, 274
75Forteo1件: Teriparatide1件: D06078 1件: PTH1R 💬3件: Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬1件: 70
76Fusion1件: Iron polymaltose---7件: 11, 13, 46, 49, 69, 70, 271
77GABAPENTIN1件: Gabapentin1件: D00332 5件: CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4,
SLC6A1 💬		9件: Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, GABAergic synapse, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway, Synaptic vesicle cycle 💬5件: 6, 13, 19, 70, 298
78Heparin1件: Heparin1件: D07510 1件: SERPINC1 💬1件: Complement and coagulation cascades 💬12件: 47, 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317
79Herbal medicine----1件: 70
80Hyaluronic acid1件: Hyaluronic acid1件: D08043 --5件: 46, 53, 70, 226, 231
81Hydromorphone1件: Hydromorphone2件: D00839 ,
D08047 		1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬1件: 70
82I-FACTOR----1件: 70
83Interbody cage (PEEK)----1件: 70
84Interbody cage (titanium)1件: Titanium---1件: 70
85Kenalog Injectable Product----1件: 70
86KETAMINE1件: Ketamine2件: D00711 ,
D08098 		5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬6件: 6, 13, 70, 113, 156, 215
87Ketanest----3件: 2, 4, 70
88Ketanest-S----3件: 2, 4, 70
89Ketorolac1件: Ketorolac2件: D00813 ,
D08104 		2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬2件: 70, 226
90Lidocaine1件: Lidocaine3件: D00358 ,
D02086 ,
D08127 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬12件: 6, 13, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256
91Lidocaine Hydrochloride, Injectable1件: Lidocaine3件: D00358 ,
D02086 ,
D08127 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 70
92Limaprost1件: Limaprost1件: D02722 1件: PTGER1 💬4件: Calcium signaling pathway, Human cytomegalovirus infection, Neuroactive ligand-receptor interaction, Pathways in cancer 💬1件: 70
93Liposomal bupivacaine1件: Bupivacaine2件: D01450 ,
D07552 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬3件: 51, 70, 96
94Lumbar epidural injection----1件: 70
95Lumbar Interbody Fusion with Autograft1件: Iron polymaltose---1件: 70
96Lumbar Interbody Fusion with NeoFuse1件: Iron polymaltose---1件: 70
97Lumbar interlaminar epidural steroid injection----1件: 70
98Magnesium1件: Magnesium---19件: 3, 6, 11, 13, 15, 46, 64, 70, 93, 97, 166, 225, 235, 256, 284, 291, 296, 297, 298
99Magnesium with ropivacaine2件: Magnesium,
Ropivacaine		2件: D04048 ,
D08490 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 70
100Manual therapy----1件: 70
101MasterGraft Granules----1件: 70
102Mecobalamin1件: Mecobalamin1件: D03246 --2件: 2, 70
103Midazolam1件: Midazolam3件: D00550 ,
D00696 ,
D05028 		16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 231, 272, 298
104MILD Procedure----1件: 70
105MILD® (Minimally Invasive Lumbar Decompression)----1件: 70
106Mirogabalin1件: Mirogabalin1件: D11203 2件: CACNA2D1,
CACNA2D2 💬		7件: Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway 💬1件: 70
107Misoprostol1件: Misoprostol1件: D00419 3件: PTGER2,
PTGER3,
PTGER4 💬		9件: Calcium signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways in cancer, Regulation of lipolysis in adipocytes, Renin secretion, cAMP signaling pathway 💬3件: 46, 70, 271
108Modal----5件: 2, 6, 17, 46, 70
109Modified-thoracolumbar interfascial plane block----1件: 70
110MONITOR1件: Methamidophos---20件: 2, 11, 13, 19, 28, 46, 49, 58, 65, 70, 81, 85, 86, 98, 113, 118, 129, 298, 299, 300
111Morphine1件: Morphine3件: D00842 ,
D02271 ,
D08233 		1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬6件: 36, 46, 70, 85, 86, 298
112Morphine PCA1件: Morphine3件: D00842 ,
D02271 ,
D08233 		1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬1件: 70
113MRI----5件: 13, 70, 78, 85, 278
114Multi-modal pain management [Acetaminophen + Gabapentin]2件: Acetaminophen,
Gabapentin		2件: D00217 ,
D00332 		7件: CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4,
PTGS1,
PTGS2,
SLC6A1 💬		31件: Adrenergic signaling in cardiomyocytes, Alzheimer disease, Arachidonic acid metabolism, Arrhythmogenic right ventricular cardiomyopathy, C-type lectin receptor signaling pathway, Cardiac muscle contraction, Chemical carcinogenesis - DNA adducts, Dilated cardiomyopathy, GABAergic synapse, Human cytomegalovirus infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MAPK signaling pathway, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, Synaptic vesicle cycle, TNF signaling pathway, VEGF signaling pathway 💬1件: 70
115Multi-modal pain management [Fentanyl]1件: Fentanyl2件: D00320 ,
D01399 		1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬1件: 70
116Multi-modal pain management [Intravenous Ketamine]1件: Ketamine2件: D00711 ,
D08098 		5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬1件: 70
117Multi-modal pain management [Valium + Gabapentin]1件: Gabapentin1件: D00332 5件: CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4,
SLC6A1 💬		9件: Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, GABAergic synapse, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway, Synaptic vesicle cycle 💬1件: 70
118NeoFuse----1件: 70
119Nicardipine1件: Nicardipine2件: D00617 ,
D08270 		4件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		37件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 70, 86
120Normal Saline----18件: 6, 13, 17, 22, 36, 46, 49, 60, 70, 94, 96, 210, 211, 226, 271, 276, 296, 299
121NS-304----3件: 70, 86, 88
122NS-304 Placebo----2件: 70, 88
123NSAIDs----4件: 46, 70, 107, 271
124NuCel----1件: 70
125Oksikodoni----1件: 70
126Opana1件: Oxymorphone1件: D08323 1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬1件: 70
127Other intervention(s)----1件: 70
128Other: Control----9件: 6, 19, 67, 70, 75, 85, 97, 162, 193
129Other: Conventional PCA mode----1件: 70
130Other: Epiduroscopy----1件: 70
131Other: Group Exercise: community setting----1件: 70
132Other: Individualized exercises: clinical setting----1件: 70
133Other: Joint Mobilizations (spine, sacroiliac, hip)----1件: 70
134Other: NO intervention----4件: 13, 70, 96, 97
135Other: Optimizing basal infusion (B.I)----1件: 70
136Other: Other intervention(s)----1件: 70
137Other: Physical Therapy----2件: 6, 70
138Oxanest----1件: 70
139Oxycodone1件: Oxycodone3件: D03783 ,
D05312 ,
D05462 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬7件: 6, 13, 46, 70, 226, 231, 298
140OXYCODONE HYDROCHLORIDE1件: Oxycodone3件: D03783 ,
D05312 ,
D05462 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬4件: 6, 70, 226, 298
141Oxycodone Orion1件: Oxycodone3件: D03783 ,
D05312 ,
D05462 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬1件: 70
142Oxygen1件: Oxygen1件: D00003 --20件: 6, 13, 19, 46, 49, 70, 84, 85, 86, 88, 90, 96, 97, 168, 193, 226, 271, 294, 299, 330
143Parathyroid hormone1件: Parathyroid hormone1件: D05364 2件: PTH1R,
PTH2R 💬		3件: Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬2件: 70, 235
144PCA----2件: 46, 70
145Percutaneous Lumbar Decompression----1件: 70
146Pharmacopuncture----1件: 70
147Philips Intelivue MP70 monitor1件: Methamidophos---1件: 70
148Phosphate1件: Phosphate ion---33件: 2, 3, 6, 11, 12, 13, 15, 28, 36, 46, 49, 51, 53, 60, 62, 65, 70, 78, 81, 83, 90, 96, 97, 164, 235, 238, 256, 276, 283, 284, 285, 286, 299
149Pleth Variability Index (PVI)----1件: 70
150PLF with autograft----1件: 70
151PLF with NeoFuse----1件: 70
152POLYDEOXYRIBONUCLEOTIDES----2件: 51, 70
153Posterolateral spinal fusion with instrumentation1件: Iron polymaltose---1件: 70
154Predinose oral----1件: 70
155Pregabalin1件: Pregabalin1件: D02716 4件: CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4 💬		7件: Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway 💬5件: 13, 36, 46, 70, 298
156Pregabalin 75mg1件: Pregabalin1件: D02716 4件: CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4 💬		7件: Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway 💬1件: 70
157Prolotherapy solution of 20% dextrose1件: Dextrose, unspecified form---1件: 70
158PROPOFOL1件: Propofol1件: D00549 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬9件: 6, 21, 22, 34, 46, 70, 84, 98, 296
159Propofol Injection1件: Propofol1件: D00549 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 70
160Remifentanil1件: Remifentanil2件: D01177 ,
D08473 		1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬2件: 6, 70
161RhPTH1件: Parathyroid hormone1件: D05364 2件: PTH1R,
PTH2R 💬		3件: Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬3件: 70, 235, 326
162RhPTH (1-34)1件: Parathyroid hormone1件: D05364 2件: PTH1R,
PTH2R 💬		3件: Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬1件: 70
163Ropivacaine1件: Ropivacaine2件: D04048 ,
D08490 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬3件: 36, 46, 70
164Ropivacaine plus normal saline1件: Ropivacaine2件: D04048 ,
D08490 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 70
165S-ketamine2件: Esketamine,
Ketamine		3件: D00711 ,
D07283 ,
D08098 		5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬1件: 70
166S-ketamine & midazolam3件: Esketamine,
Ketamine,
Midazolam		6件: D00550 ,
D00696 ,
D00711 ,
D05028 ,
D07283 ,
D08098 		21件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		25件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Spinocerebellar ataxia, Systemic lupus erythematosus, Taste transduction, cAMP signaling pathway 💬1件: 70
167Selective Nerve Root Block----1件: 70
168Selexipag1件: Selexipag1件: D09994 1件: PTGIR 💬3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬6件: 47, 51, 70, 84, 86, 88
169Standard analgesia use [Fentanyl]1件: Fentanyl2件: D00320 ,
D01399 		1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬1件: 70
170Standard analgesia use [Hydromorphone]1件: Hydromorphone2件: D00839 ,
D08047 		1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬1件: 70
171Standard analgesia use [Oxygen]1件: Oxygen1件: D00003 --1件: 70
172Standard analgesia use [Volatile Anesthesia]----1件: 70
173Steroid injections----1件: 70
174Sufentanil1件: Sufentanil2件: D00845 ,
D05938 		1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬2件: 70, 280
175Sugar pill----8件: 5, 6, 49, 67, 70, 86, 206, 210
176Teicoplanin1件: Teicoplanin1件: D02142 --2件: 70, 299
177Teriparatide1件: Teriparatide1件: D06078 1件: PTH1R 💬3件: Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬6件: 46, 68, 70, 71, 235, 274
178Teriparatide [rDNA origin] contains recombinant human parathyroid hormone (1-34)2件: Parathyroid hormone,
Teriparatide		2件: D05364 ,
D06078 		2件: PTH1R,
PTH2R 💬		3件: Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬1件: 70
179Therm-AppTM TH, thermographic camera----1件: 70
180Titanium1件: Titanium---2件: 69, 70
181Titanium cage1件: Titanium---1件: 70
182Tramadol1件: Tramadol2件: D01355 ,
D08623 		1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬5件: 46, 70, 78, 226, 271
183Tramadol with ropivacaine2件: Ropivacaine,
Tramadol		4件: D01355 ,
D04048 ,
D08490 ,
D08623 		6件: OPRM1,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		6件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction 💬1件: 70
184Tranexamic acid1件: Tranexamic acid1件: D01136 1件: PLG 💬4件: Complement and coagulation cascades, Influenza A, Neuroactive ligand-receptor interaction, Staphylococcus aureus infection 💬6件: 46, 70, 215, 227, 288, 299
185Tranexamic Acid 100 MG/ML1件: Tranexamic acid1件: D01136 1件: PLG 💬4件: Complement and coagulation cascades, Influenza A, Neuroactive ligand-receptor interaction, Staphylococcus aureus infection 💬1件: 70
186Transdermal fentanyl matrix, gabapentin2件: Fentanyl,
Gabapentin		3件: D00320 ,
D00332 ,
D01399 		6件: CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4,
OPRM1,
SLC6A1 💬		12件: Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, Estrogen signaling pathway, GABAergic synapse, Hypertrophic cardiomyopathy, MAPK signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, Synaptic vesicle cycle 💬1件: 70
187Transforaminal Epidural Injection----1件: 70
188Triamcinolone1件: Triamcinolone5件: D00385 ,
D00983 ,
D00984 ,
D00985 ,
D06216 		1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬10件: 35, 46, 56, 70, 90, 96, 107, 162, 226, 298
189Triamcinolone Acetonide and normal saline solution1件: Triamcinolone5件: D00385 ,
D00983 ,
D00984 ,
D00985 ,
D06216 		1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬1件: 70
190Tylenol----1件: 70
191Vancomycin1件: Vancomycin2件: D00212 ,
D00926 		--7件: 46, 70, 94, 96, 97, 296, 299
192ViviGen Cellular Bone Matrix----1件: 70
193With U-VANCO (vancomycin hydrochloride)1件: Vancomycin2件: D00212 ,
D00926 		--1件: 70
194Without U-VANCO (vancomycin hydrochloride)1件: Vancomycin2件: D00212 ,
D00926 		--1件: 70
195Wound topically irrigated with 500mg TXA----1件: 70
196Xylocaine1件: Lidocaine3件: D00358 ,
D02086 ,
D08127 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 70