149. 片側痙攣・片麻痺・てんかん症候群 Hemiconvulsion hemiplegia epilepsy syndrome Clinical trials / Disease details
臨床試験数 : 25 / 薬物数 : 40 - (DrugBank : 14) / 標的遺伝子数 : 17 - 標的パスウェイ数 : 20
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05260125 (ClinicalTrials.gov) | March 15, 2022 | 18/2/2022 | Comparison of the Efficacy of Ultrasound Guided vs Non-guided Suprascapular Nerve Block Treatment in Stroke Patients | Comparison of the Efficacy of Ultrasound Guided vs Non-guided Suprascapular Nerve Block Treatment in Stroke Patients With Hemiplegic Shoulder Pain. | Hemiplegia;Stroke | Drug: Ultrasound-guided Suprascapular Nerve Block;Drug: Anatomical Landmark-guided Suprascapular Nerve Block | Abant Izzet Baysal University | NULL | Not yet recruiting | 25 Years | 75 Years | All | 50 | Phase 4 | Turkey |
| 2 | NCT05163210 (ClinicalTrials.gov) | September 24, 2021 | 23/11/2021 | Effectiveness of Action Observation Therapy Based on Virtual Reality Technology in Motor Rehabilitation of Paretic Stroke Patients: a Randomized Clinical Trial | Effectiveness of Action Observation Therapy Based on Virtual Reality Technology in Motor Rehabilitation of Paretic Stroke Patients: a Randomized Clinical Trial | Stroke;Hemiplegia;Hemiparesis | Behavioral: AO+VR;Behavioral: CO+VR | Azienda Ospedaliero-Universitaria di Parma | Ministry of Health, Italy | Enrolling by invitation | 18 Years | 80 Years | All | 94 | N/A | Italy |
| 3 | NCT04630873 (ClinicalTrials.gov) | November 20, 2020 | 31/10/2020 | Low or High Botox Dilution for the Hemiplegic Gait? | Different Dilutions and Efficacy of Botulin Toxin in the Correction of the Hemiplegic Gait | Post Stroke Spastic Hemiplegia | Drug: Botulinum toxin;Diagnostic Test: gait analysis | University of Ioannina | NULL | Recruiting | 18 Years | N/A | All | 20 | Phase 1 | Greece |
| 4 | NCT04020848 (ClinicalTrials.gov) | October 28, 2019 | 12/7/2019 | Observe Alternating Hemiplegia of Childhood (OBSERV-AHC) Study | Observe Alternating Hemiplegia of Childhood (OBSERV-AHC) Prospective Observational Natural History and Therapy Study | Alternating Hemiplegia | Other: Review of past medical history, clinical exam, and electroencephalogram, polysomnography and urine samples of melatonin and pupillometry.;Other: The patients' parents have to complete the VINELAND II adaptive behavior scales scoring, The Sleep Disturbance Scale for Children (SDSC) and Horne & Ostberg Circadian Typology Questionnaire | Hospices Civils de Lyon | NULL | Recruiting | N/A | N/A | All | 40 | France | |
| 5 | JPRN-JapicCTI-194958 | 01/10/2019 | 18/09/2019 | A pharmacokinetic, safety, and tolerability study of padsevonil in CYP2C19 genotyped healthy male Japanese study participants. | An Open-Label, Parallel Group, Single-Center Study to Investigate the Pharmacokinetic, Safety, and Tolerability Profiles of Padsevonil in CYP2C19 Genotyped Healthy Male Japanese Study Participants | Epilepsy and epilepsy syndrome | Intervention name : padsevonil INN of the intervention : padsevonil Dosage And administration of the intervention : Oral administration Control intervention name : - INN of the control intervention : - Dosage And administration of the control intervention : - | UCB Japan Co., Ltd. | NULL | complete | 20 | 55 | Male | 39 | Phase 1 | Japan |
| 6 | JPRN-JapicCTI-194633 | 05/6/2019 | 15/02/2019 | A Phase 2, Multi-center, Randomized, Double-blind, Placebo-controlled Study of T-817MA in Post-stroke Patients Undergoing Rehabilitation for Upper Limb Hemiplegia | A Phase 2, Multi-center, Randomized, Double-blind, Placebo-controlled Study of T-817MA in Post-stroke Patients Undergoing Rehabilitation for Upper Limb Hemiplegia | Patients with upper limb hemiplegia after cerebral infarction or cerebral hemorrhage (other than subarachnoid hemorrhage) | Intervention name : T-817MA INN of the intervention : Edonerpic Dosage And administration of the intervention : Oral Multiple Dose Control intervention name : - INN of the control intervention : - Dosage And administration of the control intervention : - | FUJIFILM Toyama Chemical Co., Ltd | NULL | complete | 20 | 84 | BOTH | 65 | Phase 2 | Japan |
| 7 | JPRN-jRCTs042190020 | 03/05/2019 | 22/04/2019 | The Effectiveness of BEAR for hemiplegic patients | The Effectiveness of Balance Exercise Assist Robot for convalescent patients with hemiplegia after stroke - EBEARCPHAS | Stroke | Using Balance Exercise Assist Robot | Otaka Yohei | NULL | Recruiting | >= 20age old | < 90age old | Both | 60 | N/A | Japan |
| 8 | JPRN-JapicCTI-184137 | 04/1/2019 | 03/10/2018 | A Multicenter, Open-Label Study to Evaluate the Safety and Tolerability of Intravenous Brivaracetam as Replaement for Oral Brivaracetam in Japanese Subjects >=16 Years of Age with Partial Seizures With or Without Secondary Generalization | A Multicenter, Open-Label Study to Evaluate the Safety and Tolerability of Intravenous Brivaracetam as Replaement for Oral Brivaracetam in Japanese Subjects >=16 Years of Age with Partial Seizures With or Without Secondary Generalization | Epilepsy and epilepsy syndrome | Intervention name : brivaracetam INN of the intervention : brivaracetam Dosage And administration of the intervention : Intravenous (iv) injection Control intervention name : - INN of the control intervention : - Dosage And administration of the control intervention : - | UCB Japan Co., Ltd. | NULL | complete | 16 | BOTH | 10 | Phase 3 | Japan | |
| 9 | NCT03860662 (ClinicalTrials.gov) | May 26, 2018 | 8/2/2019 | The Effect of Oral Baclofen and Botulinum Toxin Treatments in Hemiplegic Spasticity on the Nociceptive Flexor Reflex | Doctor, Physical Medicine and Rehabilitation | Stroke Sequelae;Spastic Hemiplegia | Diagnostic Test: Nociceptor flexor reflex;Drug: Botox;Drug: Baclofen | Mustafa Kemal University | NULL | Completed | 18 Years | 60 Years | All | 29 | Phase 4 | Turkey |
| 10 | JPRN-JapicCTI-173615 | 22/8/2017 | 15/06/2017 | A Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study to Evaluate the Efficacy and Safety of Adjunctive Brivaracetam Subjects (>=16 to 80 Years of Age) With Partial Seizures With or Without Secondary Generalization | A Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study to Evaluate the Efficacy and Safety of Adjunctive Brivaracetam Subjects (>=16 to 80 Years of Age) With Partial Seizures With or Without Secondary Generalization | Epilepsy and epilepsy syndrome | Intervention name : ucb 34714 INN of the intervention : Brivaracetam Dosage And administration of the intervention : Oral administration Control intervention name : Placebo INN of the control intervention : - Dosage And administration of the control intervention : - | UCB Japan Co., Ltd. | NULL | recruiting | 16 | 80 | BOTH | 444 | Phase 3 | Japan, Asia except Japan |
| 11 | JPRN-JapicCTI-173687 | 05/8/2017 | 21/08/2017 | An Open-Label, Multicenter, Follow-up Study to Evaluate the Long-Term Safety and Efficacy of Brivaracetam Used as Adjunctive Treatment in Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization | An Open-Label, Multicenter, Follow-up Study to Evaluate the Long-Term Safety and Efficacy of Brivaracetam Used as Adjunctive Treatment in Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization | Epilepsy and epilepsy syndrome | Intervention name : brivaracetam INN of the intervention : brivaracetam Dosage And administration of the intervention : Oral administration Control intervention name : - INN of the control intervention : - Dosage And administration of the control intervention : - | UCB Japan Co., Ltd. | NULL | recruiting | 16 | BOTH | 214 | Phase 3 | Japan, Asia except Japan | |
| 12 | JPRN-JapicCTI-153104 | 18/3/2016 | 22/12/2015 | AN OPEN-LABEL, MULTICENTER EXTENSION STUDY TO EVALUATE THE LONG-TERM SAFETY AND EFFICACY OF LACOSAMIDE AS ADJUNCTIVE THERAPY FOR UNCONTROLLED PRIMARY GENERALIZED TONIC-CLONIC SEIZURES IN SUBJECTS WITH IDIOPATHIC GENERALIZED EPILEPSY | AN OPEN-LABEL, MULTICENTER EXTENSION STUDY TO EVALUATE THE LONG-TERM SAFETY AND EFFICACY OF LACOSAMIDE AS ADJUNCTIVE THERAPY FOR UNCONTROLLED PRIMARY GENERALIZED TONIC-CLONIC SEIZURES IN SUBJECTS WITH IDIOPATHIC GENERALIZED EPILEPSY | Epilepsy and epilepsy syndrome | Intervention name : SPM927 INN of the intervention : Lacosamide Dosage And administration of the intervention : oral administration Control intervention name : Placebo INN of the control intervention : - Dosage And administration of the control intervention : - | UCB Japan Co., Ltd. | NULL | complete | 4 | BOTH | 239 | Phase 3 | Japan, Asia except Japan, North America, Europe, Oceania | |
| 13 | JPRN-JapicCTI-153103 | 08/12/2015 | 22/12/2015 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PARALLEL-GROUP, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF LACOSAMIDE AS ADJUNCTIVE THERAPY FOR UNCONTROLLED PRIMARY GENERALIZED TONIC-CLONIC SEIZURES IN SUBJECTS WITH IDIOPATHIC GENERALIZED EPILEPSY | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PARALLEL-GROUP, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF LACOSAMIDE AS ADJUNCTIVE THERAPY FOR UNCONTROLLED PRIMARY GENERALIZED TONIC-CLONIC SEIZURES IN SUBJECTS WITH IDIOPATHIC GENERALIZED EPILEPSY | Epilepsy and epilepsy syndrome | Intervention name : SPM927 INN of the intervention : Lacosamide Dosage And administration of the intervention : oral administration Control intervention name : Placebo INN of the control intervention : - Dosage And administration of the control intervention : - | UCB Japan Co., Ltd. | NULL | complete | 4 | BOTH | 242 | Phase 3 | Japan, Asia except Japan, North America, Europe, Oceania | |
| 14 | NCT02455232 (ClinicalTrials.gov) | May 2015 | 7/5/2015 | Determine the Main Muscle Participant in the Deformation of the Elbow in Hemiplegic Patients | Determine the Main Muscle Participant in the Deformation of the Elbow in Hemiplegic Patients | Hemiplegia | Procedure: upper limb muscle block;Drug: 4cc of lidocaïne® | Centre d'Investigation Clinique et Technologique 805 | NULL | Completed | 18 Years | 75 Years | All | 20 | N/A | France |
| 15 | NCT02408354 (ClinicalTrials.gov) | April 15, 2015 | 24/3/2015 | Pilot Study, Comparative, Single-center, Randomized, Crossover, Double-blind, Against Placebo, Testing the Effectiveness of Triheptanoin Oil in Alternating Hemiplegia of Childhood | Etude Pilote, Comparative, Monocentrique, randomisée, en Cross Over, en Double Aveugle, Contre Placebo, Testant l'efficacité de l'Huile triheptanoïne Dans Les Hémiplégies Alternantes de l'Enfant HEMIHEP | Alternating Hemiplegia of Childhood | Drug: Triheptanoin;Drug: Placebo | Institut National de la Santé Et de la Recherche Médicale, France | NULL | Completed | 15 Years | N/A | All | 10 | Phase 2 | France |
| 16 | ChiCTR-ICR-15007022 | 2014-05-01 | 2015-09-06 | A research of biomechanic stimulation and healing of hemiplegia gait | A research of biomechanic stimulation and healing of hemiplegia gait | stroke | botulinum toxin A type group:inject botulinum toxin A type;conventional treatment A group :conventional treatment;Dynamic electrical stimulation treatment group:Dynamic electrical stimulation;conventional treatment B group :conventional treatment;blank control group:null;validation group :botulinum toxin A type ; | Nanjing Sports Institude | NULL | Recruiting | 40 | 70 | Both | botulinum toxin A type group:30;conventional treatment A group :30;Dynamic electrical stimulation treatment group:30;conventional treatment B group :30;blank control group:30;validation group :30; | China | |
| 17 | NCT01623622 (ClinicalTrials.gov) | July 2012 | 18/6/2012 | Study of HC-58 in Upper Limb Hemiplegic Patients After Stroke | A Phase 2 Study of HC-58 in Patients With Severe Upper Limb Hemiplegia After Stroke | Severe Upper Limb Hemiplegia | Drug: HC-58;Drug: Placebo | Asahi Kasei Pharma Corporation | NULL | Completed | 20 Years | N/A | All | 270 | Phase 2 | Japan |
| 18 | EUCTR2009-015620-29-BE (EUCTR) | 08/03/2010 | 09/02/2010 | The efficacy of the Botulinum toxin-A on the manual abilities in children with congenital spastic hemiplegia. Interest of the measure of the bimanual task performance. | The efficacy of the Botulinum toxin-A on the manual abilities in children with congenital spastic hemiplegia. Interest of the measure of the bimanual task performance. | The main objective of this study is to investigate the effect of Botulinum toxin A to improve the Upper Limb dysfunction in Hemiplegic Cerebral Palsy Children and in particular, its impact on Upper limb activity performance and how this might be translate in bimanual activities. MedDRA version: 12.0;Level: LLT;Classification code 10019475;Term: Hemiplegic infantile cerebral palsy | Trade Name: BOTOX Product Name: BOTOX Product Code: 9060X Other descriptive name: BOTULINUM TOXIN TYPE A | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 30 | Belgium | ||||
| 19 | NCT00931164 (ClinicalTrials.gov) | August 2009 | 30/6/2009 | Sodium Oxybate in Patients With Alternating Hemiplegia of Childhood (AHC-SO) | Single-center Phase I/II Trial of Sodium Oxybate in Patients With Alternating Hemiplegia of Childhood (AHC-SO Trial) | Alternating Hemiplegia of Childhood | Drug: Sodium Oxybate | University of Utah | Alternating Hemiplegia of Childhood Foundation;Jazz Pharmaceuticals | Completed | 6 Months | 25 Years | All | 6 | Phase 1/Phase 2 | United States |
| 20 | NCT00632528 (ClinicalTrials.gov) | March 2008 | 28/2/2008 | MEOPA to Improve Physical Therapy Results After Multilevel Surgery | Evaluation of the Efficacy of MEOPA Used to Obtain Better ROM Immediately After Multilevel Surgery in Children With Spastic Diplegia, Quadriplegia or Hemiplegia. | Cerebral Palsy;Spastic Diplegia;Quadriplegia;Hemiplegia | Drug: MEOPA;Drug: Medicinal air | Assistance Publique - Hôpitaux de Paris | NULL | Completed | 6 Years | 20 Years | Both | 64 | Phase 3 | France |
| 21 | EUCTR2011-004114-42-BE (EUCTR) | 06/04/2021 | Fenfluramine as anti-epilepticum in a difficult to treat epilepsy syndrome. | Fenfluramine as anti-epilepticum in Dravet syndrome. | Fenfluramine is an amphetamine which was in the past used as anorexigan. Their are a few publications of effectivness of this medication in epilepsy.We want to investigate was is the exact place of fenfluramine in the treatment of a therapy resitant epilepsy named Dravet syndrome. MedDRA version: 21.0;Level: PT;Classification code 10015037;Term: Epilepsy;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Product Name: fenfluramine INN or Proposed INN: FENFLURAMINE | University Hospital Antwerp | NULL | NA | Female: yes Male: yes | 50 | Phase 3 | Belgium |