Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	ALOX5	6件: Arachidonic acid metabolism, Metabolic pathways, Fc epsilon RI signaling pathway, Serotonergic s ...	D00414	Zileuton	3件: 85, 160, 164
2	HMGCR	4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion	D00359	Lovastatin	11件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310
3	HMGCR	4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion	D00434	Simvastatin	21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
4	HMGCR	4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion	D00887	Atorvastatin	18件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
5	HMGCR	4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion	D07474	Atorvastatin	18件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
6	IL4R	8件: Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, ...	D10354	Dupilumab	4件: 51, 98, 160, 162
7	IL12A	25件: Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like recept ...	D09214	Ustekinumab	17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
8	IL12B	25件: Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like recept ...	D09214	Ustekinumab	17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
9	IL17A	6件: Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Th17 cell differentiation, Alco ...	D09967	Secukinumab	8件: 13, 37, 41, 46, 107, 160, 269, 271
10	IL23A	9件: Cytokine-cytokine receptor interaction, C-type lectin receptor signaling pathway, JAK-STAT signa ...	D09214	Ustekinumab	17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271

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