8. ハンチントン病 Huntington disease Clinical trials / Disease details


臨床試験数 : 229 薬物数 : 193 - (DrugBank : 60) / 標的遺伝子数 : 84 - 標的パスウェイ数 : 158

  
2 trials found
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PhaseCountries
1NCT01573819
(ClinicalTrials.gov)
November 24, 201116/2/2012A Repeat Dose Study in Healthy Volunteers Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK356278A Randomised, Placebo Controlled, Ascending, Repeat Dose Study in Healthy Volunteers Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK356278Huntington DiseaseDrug: GSK356278;Drug: PlaceboGlaxoSmithKlineNULLCompleted18 Years65 YearsAll36Phase 1Netherlands
2NCT01602900
(ClinicalTrials.gov)
November 22, 20111/12/2011Healthy Volunteer Positron Emission Tomography (PET) Brain Occupancy Study of a Phosphodiesterase 4 (PDE4) Inhibitor in Huntington's DiseaseAn Open Label Positron Emission Tomography Study in Healthy Male Subjects to Investigate Brain PDE4 Engagement, Pharmacokinetics and Safety of Single Oral Doses of GSK356278, Using 11C-(R)-Rolipram as a PET Ligand(s)Huntington DiseaseDrug: GSK356278;Drug: RolipramGlaxoSmithKlineNULLCompleted22 Years55 YearsMale8Phase 1United Kingdom