6R-BH4 ( DrugBank: 6R-BH4 )

3 diseases

86. 肺動脈性肺高血圧症

臨床試験数 : 1,181 / 薬物数 : 701 - (DrugBank : 126) / 標的遺伝子数 : 105 - 標的パスウェイ数 : 192

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00435331 (ClinicalTrials.gov)	March 2008	12/2/2007	6R-BH4 Pulmonary Arterial Hypertension Study	A Phase 1, Multicenter, Open-label, Dose-escalation Study to Evaluate the Safety and Efficacy of 6R- ...	Pulmonary Arterial Hypertension	Drug: sapropterin dihydrochloride (6R-BH4)	Vanderbilt University	National Institutes of Health (NIH);BioMarin Pharmaceutical	Completed	18 Years	N/A	Both	14	Phase 1	United States

臨床試験数 : 12 / 薬物数 : 14 - (DrugBank : 5) / 標的遺伝子数 : 6 - 標的パスウェイ数 : 23

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2007-004370-55-IT (EUCTR)	14/12/2007	11/12/2007	Effects of tetrahydrobiopterin (6R-BH4) on flow-mediated dilation in CADASIL patients: a randomised ...	Effects of tetrahydrobiopterin (6R-BH4) on flow-mediated dilation in CADASIL patients: a randomised ...	CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) ...	Product Name: Phenoptin Product Code: 6R-BH4 INN or Proposed INN: sapropterin	AZIENDA OSPEDALIERA OSPEDALE NIGUARDA CA' GRANDA (A.O. DI RILIEVO NAZIONALE)	NULL	Not Recruiting			Female: yes Male: yes			Italy

臨床試験数 : 138 / 薬物数 : 106 - (DrugBank : 11) / 標的遺伝子数 : 1 - 標的パスウェイ数 : 5

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00104247 (ClinicalTrials.gov)	March 2005	24/2/2005	Study to Evaluate the Safety and Efficacy of Phenoptin™ in Subjects With Phenylketonuria Who Have El ...	A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ...	Phenylketonurias	Drug: sapropterin dihydrochloride, 6R-BH4, tetrahydrobiopterin	BioMarin Pharmaceutical	NULL	Completed	8 Years	N/A	All	89	Phase 3	United States