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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
10 mg Prednisone1件: Prednisone1件: Prednisone 💬1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬1件: 44 💬
25 mg Prednisone1件: Prednisone1件: Prednisone 💬1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬1件: 44 💬
3Abatacept1件: Abatacept1件: Abatacept 💬2件: CD80,
CD86 💬		13件: Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬26件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
4Abatacept (CTLA4-Ig)1件: Abatacept1件: Abatacept 💬2件: CD80,
CD86 💬		13件: Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬1件: 44 💬
5ALEMTUZUMAB1件: Alemtuzumab1件: Alemtuzumab 💬1件: CD52 💬-17件: 13, 15, 19, 20, 36, 43, 44, 46, 51, 60, 63, 65, 85, 96, 164, 283, 284 💬
6Anti-interleukin 5 (IL-5) humanized monoclonal----2件: 44, 45 💬
7Avacopan1件: Avacopan1件: Avacopan 💬1件: C5AR1 💬6件: Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Staphylococcus aureus infection 💬3件: 43, 44, 222 💬
8Azathioprin-ratiopharm® 25 mg Filmtabletten----1件: 44 💬
9Azathioprine1件: Azathioprine1件: Azathioprine 💬--21件: 6, 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 63, 65, 66, 85, 93, 94, 95, 96, 97, 162 💬
10Azathioprine 25 mg1件: Azathioprine1件: Azathioprine 💬--1件: 44 💬
11AZD7986----2件: 44, 299 💬
12BELIMUMAB1件: Belimumab1件: Belimumab 💬1件: TNFSF13B 💬4件: Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬13件: 11, 13, 43, 44, 46, 49, 51, 53, 63, 66, 222, 296, 300 💬
13Benralizumab1件: Benralizumab1件: Benralizumab 💬1件: IL5RA 💬4件: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, Pathways in cancer 💬5件: 44, 45, 98, 162, 299 💬
14Biological: Benralizumab, Biological: Placebo to Mepolizumab2件: Benralizumab,
Mepolizumab		2件: Mepolizumab ,
Benralizumab 💬		2件: IL5,
IL5RA 💬		13件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation 💬1件: 44 💬
15Biological: Mepolizumab, Biological: Placebo to Benralizumab2件: Benralizumab,
Mepolizumab		2件: Mepolizumab ,
Benralizumab 💬		2件: IL5,
IL5RA 💬		13件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation 💬1件: 44 💬
16Blisibimod1件: Blisibimod1件: Blisibimod 💬--5件: 43, 44, 49, 63, 66 💬
17CCX168----5件: 43, 44, 66, 109, 222 💬
18Chimeric monoclonal antibody, IgG4 subtype----2件: 43, 44 💬
19Corticosteroid----9件: 13, 42, 43, 44, 45, 66, 96, 97, 222 💬
20Corticosteroid and azathioprine1件: Azathioprine1件: Azathioprine 💬--4件: 42, 43, 44, 45 💬
21Cyclophosphamide1件: Cyclophosphamide2件: Cyclophosphamide ,
Cyclophosphamide 💬		--44件: 11, 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 205, 222, 224, 256, 274, 283, 284, 285, 288, 326, 331 💬
22Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids3件: Azathioprine,
Cyclophosphamide,
Methotrexate		4件: Methotrexate ,
Azathioprine ,
Cyclophosphamide ,
Cyclophosphamide 💬		2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 44 💬
23Cyclophosphamidum1件: Cyclophosphamide2件: Cyclophosphamide ,
Cyclophosphamide 💬		--1件: 44 💬
24Cyclophosphamidum 500 mg1件: Cyclophosphamide2件: Cyclophosphamide ,
Cyclophosphamide 💬		--1件: 44 💬
25Depemokimab----2件: 44, 45 💬
26ENDOXAN----7件: 13, 28, 43, 44, 85, 96, 222 💬
27Endoxan® 500 mg----1件: 44 💬
28Fasenra1件: Benralizumab1件: Benralizumab 💬1件: IL5RA 💬4件: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, Pathways in cancer 💬5件: 44, 45, 98, 162, 299 💬
29GALEN® tablet----2件: 43, 44 💬
30Glucocorticoid (GC)----2件: 43, 44 💬
31Glucocorticoids----8件: 40, 41, 43, 44, 60, 62, 75, 300 💬
32Glucocorticoids (GC)----2件: 43, 44 💬
33Glucocorticoids - Reduced Dose----2件: 43, 44 💬
34Glucocorticoids - Standard Dose----2件: 43, 44 💬
35Glucocorticoids [Reduced Dose]----2件: 43, 44 💬
36Glucocorticoids [Standard Dose]----2件: 43, 44 💬
37GSK3511294----2件: 44, 45 💬
38Gusperimus1件: Gusperimus1件: Gusperimus 💬--1件: 44 💬
39Gusperimus + glucocorticoids1件: Gusperimus1件: Gusperimus 💬--1件: 44 💬
40Hydroxychloroquine1件: Hydroxychloroquine1件: Hydroxychloroquine 💬--27件: 13, 34, 41, 43, 44, 45, 46, 48, 49, 53, 56, 63, 66, 84, 89, 90, 96, 97, 107, 218, 222, 224, 234, 254, 271, 298, 299 💬
41IFX-11件: Vilobelimab1件: Vilobelimab 💬1件: C5 💬11件: Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Herpes simplex virus 1 infection, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Pertussis, Prion disease, Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus 💬3件: 43, 44, 269 💬
42INS1007----2件: 44, 299 💬
43L04AC06----2件: 44, 45 💬
44MabThera1件: Rituximab1件: Rituximab 💬1件: MS4A1 💬1件: Hematopoietic cell lineage 💬22件: 11, 13, 14, 19, 35, 43, 44, 46, 49, 50, 51, 52, 53, 61, 63, 64, 65, 83, 93, 162, 222, 271 💬
45Mabthera®1件: Rituximab1件: Rituximab 💬1件: MS4A1 💬1件: Hematopoietic cell lineage 💬6件: 13, 35, 43, 44, 46, 93 💬
46MEDI-563----5件: 44, 45, 98, 162, 299 💬
47Meperizumab injection----1件: 44 💬
48MEPOLIZUMAB1件: Mepolizumab1件: Mepolizumab 💬1件: IL5 💬13件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation 💬4件: 44, 45, 98, 162 💬
49Mesna1件: Coenzyme M---10件: 11, 13, 44, 45, 51, 60, 65, 85, 96, 164 💬
50Metex 2,5 mg Tabletten----1件: 44 💬
51Methotrexate1件: Methotrexate1件: Methotrexate 💬2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
52Methotrexate 2.5 mg1件: Methotrexate1件: Methotrexate 💬2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 44 💬
53Methotrexate 25 mg1件: Methotrexate1件: Methotrexate 💬2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 44 💬
54METOJECT 10 mg/ml, solution injectable en seringue pré-remplie1件: Methotrexate1件: Methotrexate 💬2件: DHFR,
DHFR2 💬		5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬1件: 44 💬
55Mycophenolate1件: Mycophenolic acid1件: Mycophenolic acid 💬2件: IMPDH1,
IMPDH2 💬		4件: Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Purine metabolism 💬36件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬
56Mycophenolate mofetil2件: Mycophenolate mofetil,
Mycophenolic acid		2件: Mycophenolate mofetil ,
Mycophenolic acid 💬		2件: IMPDH1,
IMPDH2 💬		4件: Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Purine metabolism 💬34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬
57Mycophénolate mofétil----1件: 44 💬
58Naltrexone1件: Naltrexone1件: Naltrexone 💬3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬12件: 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
59NALTREXONE HYDROCHLORIDE1件: Naltrexone1件: Naltrexone 💬3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬8件: 10, 40, 41, 42, 43, 44, 45, 96 💬
60NUCALA1件: Mepolizumab1件: Mepolizumab 💬1件: IL5 💬13件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation 💬2件: 44, 45 💬
61Nucala 100 mg powder for solution for injection1件: Mepolizumab1件: Mepolizumab 💬1件: IL5 💬13件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation 💬2件: 44, 45 💬
62NUCALA®1件: Mepolizumab1件: Mepolizumab 💬1件: IL5 💬13件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation 💬1件: 44 💬
63Obinutuzumab1件: Obinutuzumab1件: Obinutuzumab 💬1件: MS4A1 💬1件: Hematopoietic cell lineage 💬4件: 43, 44, 49, 222 💬
64ORENCIA1件: Abatacept1件: Abatacept 💬2件: CD80,
CD86 💬		13件: Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬14件: 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 160, 222, 271 💬
65Pednisone----2件: 43, 44 💬
66Plaquenil - Hydroxychloroquine 200mg Film coated tablets1件: Hydroxychloroquine1件: Hydroxychloroquine 💬--3件: 43, 44, 45 💬
67PREDNISOLONE1件: Prednisolone1件: Prednisolone 💬1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬42件: 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
68Prednison acis® 20 mg----2件: 43, 44 💬
69Prednison acis® 5 mg----2件: 43, 44 💬
70Prednison acis¿ 20 mg----2件: 43, 44 💬
71Prednison acis¿ 5 mg----2件: 43, 44 💬
72Prednisone1件: Prednisone1件: Prednisone 💬1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬45件: 2, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331 💬
73PredniSONE Tablets, USP1件: Prednisone1件: Prednisone 💬1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬3件: 41, 43, 44 💬
74Recombinant humanized monoclonal antibody specific for human IL-5----1件: 44 💬
75Remission induction therapy----2件: 43, 44 💬
76Reslizumab1件: Reslizumab1件: Reslizumab 💬1件: IL5 💬13件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation 💬2件: 44, 98 💬
77RITUXIMAB1件: Rituximab1件: Rituximab 💬1件: MS4A1 💬1件: Hematopoietic cell lineage 💬48件: 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
78Rituximab (Arm A)1件: Rituximab1件: Rituximab 💬1件: MS4A1 💬1件: Hematopoietic cell lineage 💬2件: 43, 44 💬
79Rituximab (Arm B)1件: Rituximab1件: Rituximab 💬1件: MS4A1 💬1件: Hematopoietic cell lineage 💬2件: 43, 44 💬
80RO0452294/V01----2件: 43, 44 💬
81RO0452294/V02----3件: 35, 43, 44 💬
82RoActemra1件: Tocilizumab1件: Tocilizumab 💬1件: IL6R 💬12件: Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬11件: 40, 41, 44, 46, 50, 51, 86, 107, 266, 271, 331 💬
83SB-240563----3件: 44, 45, 98 💬
84SB-240563 (mepolizumab)1件: Mepolizumab1件: Mepolizumab 💬1件: IL5 💬13件: Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation 💬2件: 44, 45 💬
85Sulfamethoxazole1件: Sulfamethoxazole1件: Sulfamethoxazole 💬--5件: 44, 49, 61, 85, 299 💬
86Tocilizumab1件: Tocilizumab1件: Tocilizumab 💬1件: IL6R 💬12件: Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬21件: 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
87Tofacitinib1件: Tofacitinib1件: Tofacitinib 💬4件: JAK1,
JAK2,
JAK3,
TYK2 💬		37件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
88Trimethoprim1件: Trimethoprim1件: Trimethoprim 💬--7件: 36, 44, 49, 60, 61, 85, 299 💬
89Trimethoprim Sulfamethoxazole2件: Sulfamethoxazole,
Trimethoprim		2件: Trimethoprim ,
Sulfamethoxazole 💬		--1件: 44 💬
90Vilobelimab1件: Vilobelimab1件: Vilobelimab 💬1件: C5 💬11件: Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Herpes simplex virus 1 infection, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Pertussis, Prion disease, Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus 💬2件: 43, 44 💬
91Vitamin D2件: Cholecalciferol,
Vitamin D		1件: Cholecalciferol 💬1件: VDR 💬5件: Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬20件: 13, 19, 41, 43, 44, 46, 49, 50, 68, 93, 95, 96, 97, 179, 222, 228, 235, 274, 298, 299 💬
92Yellow fever vaccine1件: Yellow fever vaccine1件: Yellow fever vaccine 💬--8件: 40, 44, 46, 50, 51, 52, 53, 107 💬
93Yellow Fever vaccine (17D)1件: Yellow fever vaccine1件: Yellow fever vaccine 💬--8件: 40, 44, 46, 50, 51, 52, 53, 107 💬