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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
指定難病告示番号
1
JAK1
💬
1.
JAK1
×
Name
Full Name
JAK1
Janus kinase 1
27件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
NOD-like receptor signaling pathway
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Viral carcinogenesis
,
Pancreatic cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
27件:
EGFR tyrosine kinase inhibitor resistance
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Osteoclast
...
Ruxolitinib
Ruxolitinib
💬
1.
JAK1
×
Name
Other Names
Ruxolitinib
Ruxolitinib (USAN/INN)
ルキソリチニブ
Ruxolitinib
3件:
60
60
,
65
,
228
💬
1.
JAK1
×
告示番号
日本語名
英語名
60
再生不良性貧血
Aplastic anemia
65
原発性免疫不全症候群
Primary immunodeficiency
228
閉塞性細気管支炎
Bronchiolitis obliterans
2
JAK1
💬
2.
JAK1
×
Name
Full Name
JAK1
Janus kinase 1
27件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
NOD-like receptor signaling pathway
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Viral carcinogenesis
,
Pancreatic cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
27件:
EGFR tyrosine kinase inhibitor resistance
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Osteoclast
...
Tofacitinib
Tofacitinib
💬
2.
JAK1
×
Name
Other Names
Tofacitinib
Tofacitinib (USAN)
Tasocitinib
トファシチニブ
タソシチニブ
Tofacitinib
15件:
11
11
,
40
,
44
,
46
,
49
,
50
,
51
,
53
,
65
,
84
,
96
,
97
,
107
,
271
,
300
💬
2.
JAK1
×
告示番号
日本語名
英語名
11
重症筋無力症
Myasthenia gravis
40
高安動脈炎;大動脈炎症候群
Takayasu arteritis
44
多発血管炎性肉芽腫症;ウェゲナー肉芽腫症
Wegener granulomatosis
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
50
皮膚筋炎／多発性筋炎
Dermatomyositis
51
全身性強皮症
Scleroderma
53
シェーグレン症候群
Sjogren syndrome
65
原発性免疫不全症候群
Primary immunodeficiency
84
サルコイドーシス
Sarcoidosis
96
クローン病;回腸末端炎
Crohn disease
97
潰瘍性大腸炎
Ulcerative colitis
107
若年性特発性関節炎
Juvenile idiopathic arthritis
271
強直性脊椎炎
Ankylosing spondylitis
300
IgG4関連疾患
IgG4-related disease
3
JAK1
💬
3.
JAK1
×
Name
Full Name
JAK1
Janus kinase 1
27件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
NOD-like receptor signaling pathway
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Viral carcinogenesis
,
Pancreatic cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
27件:
EGFR tyrosine kinase inhibitor resistance
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Osteoclast
...
Baricitinib
Baricitinib
💬
3.
JAK1
×
Name
Other Names
Baricitinib
Baricitinib (JAN/USAN/INN)
Olumiant (TN)
OTHER BARICITINIB
バリシチニブ
オルミエント
Baricitinib
13件:
2
2
,
41
,
46
,
49
,
50
,
51
,
53
,
93
,
107
,
162
,
265
,
269
,
325
💬
3.
JAK1
×
告示番号
日本語名
英語名
2
筋萎縮性側索硬化症
Amyotrophic lateral sclerosis
41
巨細胞性動脈炎;側頭動脈炎
Giant cell arteritis
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
50
皮膚筋炎／多発性筋炎
Dermatomyositis
51
全身性強皮症
Scleroderma
53
シェーグレン症候群
Sjogren syndrome
93
原発性胆汁性胆管炎
Primary biliary cholangitis
107
若年性特発性関節炎
Juvenile idiopathic arthritis
162
類天疱瘡（後天性表皮水疱症を含む。）
Pemphigoid
265
脂肪萎縮症
Lipodystrophy
269
化膿性無菌性関節炎・壊疽性膿皮症・アクネ症候群;PAPA症候群
Pyogenic arthritis
325
遺伝性自己炎症疾患
Hereditary autoinflammatory syndrome
4
JAK1
💬
4.
JAK1
×
Name
Full Name
JAK1
Janus kinase 1
27件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
NOD-like receptor signaling pathway
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Viral carcinogenesis
,
Pancreatic cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
27件:
EGFR tyrosine kinase inhibitor resistance
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Osteoclast
...
Peficitinib
Peficitinib
💬
4.
JAK1
×
Name
Other Names
Peficitinib
Peficitinib (USAN/INN)
ペフィシチニブ
Peficitinib
1件:
46
46
💬
4.
JAK1
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
5
JAK1
💬
5.
JAK1
×
Name
Full Name
JAK1
Janus kinase 1
27件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
NOD-like receptor signaling pathway
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Viral carcinogenesis
,
Pancreatic cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
27件:
EGFR tyrosine kinase inhibitor resistance
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Osteoclast
...
Filgotinib
Filgotinib
💬
5.
JAK1
×
Name
Other Names
Filgotinib
Filgotinib (USAN/INN)
フィルゴチニブ
Filgotinib
6件:
46
46
,
53
,
96
,
97
,
222
,
271
💬
5.
JAK1
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
53
シェーグレン症候群
Sjogren syndrome
96
クローン病;回腸末端炎
Crohn disease
97
潰瘍性大腸炎
Ulcerative colitis
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
271
強直性脊椎炎
Ankylosing spondylitis
6
JAK1
💬
6.
JAK1
×
Name
Full Name
JAK1
Janus kinase 1
27件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
NOD-like receptor signaling pathway
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Viral carcinogenesis
,
Pancreatic cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
27件:
EGFR tyrosine kinase inhibitor resistance
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Osteoclast
...
Itacitinib
Itacitinib
💬
6.
JAK1
×
Name
Other Names
Itacitinib
Itacitinib (USAN/INN)
イタシチニブ
Itacitinib
4件:
46
46
,
51
,
97
,
228
💬
6.
JAK1
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
51
全身性強皮症
Scleroderma
97
潰瘍性大腸炎
Ulcerative colitis
228
閉塞性細気管支炎
Bronchiolitis obliterans
7
JAK1
💬
7.
JAK1
×
Name
Full Name
JAK1
Janus kinase 1
27件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
NOD-like receptor signaling pathway
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Viral carcinogenesis
,
Pancreatic cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
27件:
EGFR tyrosine kinase inhibitor resistance
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Osteoclast
...
Upadacitinib
Upadacitinib
💬
7.
JAK1
×
Name
Other Names
Upadacitinib
Upadacitinib (USAN/INN)
RINVOQ
ウパダシチニブ
Upadacitinib
8件:
40
40
,
41
,
46
,
49
,
96
,
97
,
107
,
271
💬
7.
JAK1
×
告示番号
日本語名
英語名
40
高安動脈炎;大動脈炎症候群
Takayasu arteritis
41
巨細胞性動脈炎;側頭動脈炎
Giant cell arteritis
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
96
クローン病;回腸末端炎
Crohn disease
97
潰瘍性大腸炎
Ulcerative colitis
107
若年性特発性関節炎
Juvenile idiopathic arthritis
271
強直性脊椎炎
Ankylosing spondylitis
8
JAK1
💬
8.
JAK1
×
Name
Full Name
JAK1
Janus kinase 1
27件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
NOD-like receptor signaling pathway
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Viral carcinogenesis
,
Pancreatic cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
27件:
EGFR tyrosine kinase inhibitor resistance
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Osteoclast
...
Abrocitinib
Abrocitinib
💬
8.
JAK1
×
Name
Other Names
Abrocitinib
Abrocitinib (JAN/USAN)
Cibinqo (TN)
アブロシチニブ
サイバインコ
Abrocitinib
1件:
84
84
💬
8.
JAK1
×
告示番号
日本語名
英語名
84
サルコイドーシス
Sarcoidosis