Target Gene/Pathway Pathway / Gene
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No. | KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related | KEGG GENES | KEGG DRUG | DrugBank | 指定難病告示番号 |
---|---|---|---|---|---|
1 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
ABL1 1件: ABL1 💬 |
D03252 D03252 💬 |
Bosutinib | 002 2件: 2 , 67 💬 |
2 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
ABL1 1件: ABL1 💬 |
D09664 D09664 💬 |
Saracatinib | 006 3件: 6 , 89, 272 💬 |
3 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
ABL1 4件: ABL1, EPHA2, KIT, PDGFRB 💬 |
D03658 D03658 💬 |
Dasatinib | 051 2件: 51, 85 💬 |
4 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
ABL1 4件: ABL1, EPHA2, KIT, PDGFRB 💬 |
D06414 D06414 💬 |
Dasatinib | 051 2件: 51, 85 💬 |
5 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
ABL1 3件: ABL1, KIT, PDGFRA 💬 |
D08066 D08066 💬 |
Imatinib | 013 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 |
6 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
ABL1 4件: ABL1, KIT, PDGFRA, PDGFRB 💬 |
D08953 D08953 💬 |
Nilotinib | 006 5件: 6 , 8 , 34, 51, 86 💬 |
7 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
CSF1R 8件: CSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 |
D08552 D08552 💬 |
Sunitinib | 028 2件: 28, 34 💬 |
8 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
CSF1R 3件: CSF1R, FLT3, KIT 💬 |
D11270 D11270 💬 |
Pexidartinib | 034 1件: 34 💬 |
9 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D03455 D03455 💬 |
Cetuximab | 051 2件: 51, 86 💬 |
10 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D07907 D07907 💬 |
Erlotinib | 094 1件: 94 💬 |
11 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D01977 D01977 💬 |
Gefitinib | 075 1件: 75 💬 |
12 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D11251 D11251 💬 |
Icotinib | 034 1件: 34 💬 |
13 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D08108 D08108 💬 |
Lapatinib | 034 3件: 34, 74, 75 💬 |
14 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D08950 D08950 💬 |
Neratinib | 034 1件: 34 💬 |
15 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
EGFR 3件: EGFR, FLT4, KDR 💬 |
D11772 D11772 💬 |
Tesevatinib | 067 1件: 67 💬 |
16 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
FGF23 1件: FGF23 💬 |
D10913 D10913 💬 |
Burosumab | 238 1件: 238 💬 |
17 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
FGFR1 3件: FGFR1, FGFR2, FGFR3 💬 |
D11589 D11589 💬 |
Infigratinib | 276 1件: 276 💬 |
18 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
FGFR1 8件: FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 |
D10481 D10481 💬 |
Nintedanib | 051 5件: 51, 85, 89, 227, 228 💬 |
19 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
FGFR2 1件: FGFR2 💬 |
D05338 D05338 💬 |
Palifermin | 013 5件: 13, 36, 38, 39, 65 💬 |
20 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
FLT1 3件: FLT1, FLT4, KDR 💬 |
D03218 D03218 💬 |
Axitinib | 034 1件: 34 💬 |
21 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
FLT1 3件: FLT1, FLT4, KDR 💬 |
D08881 D08881 💬 |
Cediranib | 034 1件: 34 💬 |
22 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
FLT3 6件: FLT3, FLT4, KDR, KIT, PDGFRB, RAF1 💬 |
D08524 D08524 💬 |
Sorafenib | 034 2件: 34, 86 💬 |
23 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
GRIN1 3件: GRIN1, GRIN2A, GRIN2B 💬 |
D07058 D07058 💬 |
Acamprosate | 006 2件: 6 , 206 💬 |
24 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
GRIN1 3件: GRIN1, GRIN2A, GRIN2B 💬 |
D07441 D07441 💬 |
Amantadine | 006 4件: 6 , 8 , 13, 127 💬 |
25 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
GRIN1 3件: GRIN1, GRIN2A, GRIN2B 💬 |
D03742 D03742 💬 |
Dextromethorphan | 002 11件: 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 |
26 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
GRIN1 3件: GRIN1, GRIN2A, GRIN2B 💬 |
D07283 D07283 💬 |
Esketamine | 002 3件: 2 , 4 , 70 💬 |
27 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
GRIN1 3件: GRIN1, GRIN2A, GRIN2B 💬 |
D08098 D08098 💬 |
Ketamine | 002 8件: 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 |
28 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
GRIN1 3件: GRIN1, GRIN2A, GRIN2B 💬 |
D09917 D09917 💬 |
Latrepirdine | 008 1件: 8 💬 |
29 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
GRIN1 3件: GRIN1, GRIN2A, GRIN2B 💬 |
D08174 D08174 💬 |
Memantine | 002 8件: 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 |
30 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
GRIN1 3件: GRIN1, GRIN2A, GRIN2B 💬 |
D00775 D00775 💬 |
Riluzole | 002 9件: 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 |
31 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
IGF1R 1件: IGF1R 💬 |
D09925 D09925 💬 |
Linsitinib | 232 1件: 232 💬 |
32 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
IGF1R 1件: IGF1R 💬 |
D03297 D03297 💬 |
Mecasermin | 065 6件: 65, 78, 96, 168, 265, 299 💬 |
33 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
IGF1R 1件: IGF1R 💬 |
D09680 D09680 💬 |
Teprotumumab | 051 1件: 51 💬 |
34 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
INSR 1件: INSR 💬 |
D04539 D04539 💬 |
Insulin detemir | 299 1件: 299 💬 |
35 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
INSR 1件: INSR 💬 |
D03250 D03250 💬 |
Insulin glargine | 299 1件: 299 💬 |
36 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
INSR 1件: INSR 💬 |
D03230 D03230 💬 |
Insulin human | 096 2件: 96, 156 💬 |
37 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
KDR 2件: KDR, MET 💬 |
D10062 D10062 💬 |
Cabozantinib | 034 1件: 34 💬 |
38 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
KIT 1件: KIT 💬 |
D10229 D10229 💬 |
Masitinib | 002 6件: 2 , 5 , 6 , 13, 46, 96 💬 |
39 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10604 D10604 💬 |
Binimetinib | 034 1件: 34 💬 |
40 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10405 D10405 💬 |
Cobimetinib | 280 1件: 280 💬 |
41 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D11675 D11675 💬 |
Mirdametinib | 034 1件: 34 💬 |
42 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D09666 D09666 💬 |
Selumetinib | 034 1件: 34 💬 |
43 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10175 D10175 💬 |
Trametinib | 002 4件: 2 , 34, 279, 280 💬 |
44 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
NFKB1 1件: NFKB1 💬 |
D01146 D01146 💬 |
Iguratimod | 046 5件: 46, 51, 53, 271, 300 💬 |
45 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
NGF 1件: NGF 💬 |
D09387 D09387 💬 |
Tanezumab | 226 2件: 226, 298 💬 |
46 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
NGFR 1件: NGFR 💬 |
D11028 D11028 💬 |
Cenegermin | 053 2件: 53, 90 💬 |
47 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
PGF 3件: PGF, VEGFA, VEGFB 💬 |
D09574 D09574 💬 |
Aflibercept | 090 2件: 90, 166 💬 |
48 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
PIK3CA 1件: PIK3CA 💬 |
D11011 D11011 💬 |
Alpelisib | 138 1件: 138 💬 |
49 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
PIK3CA 3件: PIK3CA, PIK3CB, PIK3CD 💬 |
D11158 D11158 💬 |
Leniolisib | 053 2件: 53, 65 💬 |
50 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
PIK3CD 1件: PIK3CD 💬 |
D11437 D11437 💬 |
Parsaclisib | 035 3件: 35, 53, 61 💬 |
51 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
PRKCB 1件: PRKCB 💬 |
D11935 D11935 💬 |
Enzastaurin | 168 1件: 168 💬 |
52 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
RELA 1件: RELA 💬 |
D12181 D12181 💬 |
Edasalonexent | 113 1件: 113 💬 |
53 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
VEGFA 1件: VEGFA 💬 |
D06409 D06409 💬 |
Bevacizumab | 013 6件: 13, 34, 85, 87, 227, 280 💬 |
54 | Ras signaling pathway 💬 Related to 35 target genes, 53 drugs (DrugBank) and 62 diseases in DDrare |
VEGFA 1件: VEGFA 💬 |
D05697 D05697 💬 |
Ranibizumab | 034 4件: 34, 166, 227, 301 💬 |