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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1Acetate[1] Acetate---[41] 1, 2, 6, 10, 13, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 171, 206, 222, 224, 225, 227, 235, 251, 265, 288, 298, 299
2ALX-0081----[1] 64
3ALX0081----[1] 64
4Anfibatide[1] Anfibatide---[1] 64
5Anti-CD20 antibody----[1] 64
6Anti-von Willebrand Factor Nanobody[1] Von Willebrand factor human---[1] 64
7Anti-von Willebrand Factor Nanobody, Caplacizumab[2] Caplacizumab,
Von Willebrand factor human		[1] D11160 [1] VWF 💬[8] Complement and coagulation cascades, Coronavirus disease - COVID-19, ECM-receptor interaction, Focal adhesion, Human papillomavirus infection, Neutrophil extracellular trap formation, PI3K-Akt signaling pathway, Platelet activation 💬[1] 64
8Anti-von Willebrand Factor Nanobody, INN = Caplacizumab[2] Caplacizumab,
Von Willebrand factor human		[1] D11160 [1] VWF 💬[8] Complement and coagulation cascades, Coronavirus disease - COVID-19, ECM-receptor interaction, Focal adhesion, Human papillomavirus infection, Neutrophil extracellular trap formation, PI3K-Akt signaling pathway, Platelet activation 💬[1] 64
9Apadamtase alfa[1] Apadamtase alfa---[1] 64
10Apademtase alfa----[1] 64
11ARC 1779----[2] 64, 288
12ARC1779----[2] 64, 288
13ARC1779 Injection----[2] 64, 288
14Aspirin[1] Acetylsalicylic acid[1] D00109 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[12] 13, 22, 46, 49, 51, 58, 64, 86, 113, 158, 210, 231
15Aspirin tablet[1] Acetylsalicylic acid[1] D00109 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 64
16BAX930----[1] 64
17BAX930 - RECOMBINANT HUMAN ADAMTS13----[1] 64
18BAX930 or SHP655----[1] 64
19BAX930 or SHP655 or TAK755----[1] 64
20BORTEZOMIB[1] Bortezomib[1] D03150 [1] PSMB5 💬[8] Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Prion disease, Proteasome, Spinocerebellar ataxia 💬[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331
21Bortezomib Injection[1] Bortezomib[1] D03150 [1] PSMB5 💬[8] Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Prion disease, Proteasome, Spinocerebellar ataxia 💬[1] 64
22CABLIVI[1] Caplacizumab[1] D11160 [1] VWF 💬[8] Complement and coagulation cascades, Coronavirus disease - COVID-19, ECM-receptor interaction, Focal adhesion, Human papillomavirus infection, Neutrophil extracellular trap formation, PI3K-Akt signaling pathway, Platelet activation 💬[1] 64
23Cablivi®[1] Caplacizumab[1] D11160 [1] VWF 💬[8] Complement and coagulation cascades, Coronavirus disease - COVID-19, ECM-receptor interaction, Focal adhesion, Human papillomavirus infection, Neutrophil extracellular trap formation, PI3K-Akt signaling pathway, Platelet activation 💬[1] 64
24CAPLACIZUMAB[1] Caplacizumab[1] D11160 [1] VWF 💬[8] Complement and coagulation cascades, Coronavirus disease - COVID-19, ECM-receptor interaction, Focal adhesion, Human papillomavirus infection, Neutrophil extracellular trap formation, PI3K-Akt signaling pathway, Platelet activation 💬[1] 64
25Caplacizumab (ALX-0081)[1] Caplacizumab[1] D11160 [1] VWF 💬[8] Complement and coagulation cascades, Coronavirus disease - COVID-19, ECM-receptor interaction, Focal adhesion, Human papillomavirus infection, Neutrophil extracellular trap formation, PI3K-Akt signaling pathway, Platelet activation 💬[1] 64
26Caplacizumab (an anti-von Willebrand Factor Nanobody ALX-0081)[2] Caplacizumab,
Von Willebrand factor human		[1] D11160 [1] VWF 💬[8] Complement and coagulation cascades, Coronavirus disease - COVID-19, ECM-receptor interaction, Focal adhesion, Human papillomavirus infection, Neutrophil extracellular trap formation, PI3K-Akt signaling pathway, Platelet activation 💬[1] 64
27Caplacizumab (an anti-von Willebrand Factor Nanobody)[2] Caplacizumab,
Von Willebrand factor human		[1] D11160 [1] VWF 💬[8] Complement and coagulation cascades, Coronavirus disease - COVID-19, ECM-receptor interaction, Focal adhesion, Human papillomavirus infection, Neutrophil extracellular trap formation, PI3K-Akt signaling pathway, Platelet activation 💬[1] 64
28Corticosteroid treatment (Methylprednisolone or prednisolone)[2] Methylprednisolone,
Prednisolone		[2] D00407 ,
D00472 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[1] 64
29Corticosteroids----[12] 41, 46, 49, 63, 64, 97, 107, 113, 164, 220, 296, 300
30Cryosupernatant plasma----[1] 64
31Cyclosporine[1] Cyclosporine[1] D00184 [5] PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[33] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[37] 11, 19, 20, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 107, 162, 164, 222, 226, 228, 234, 283, 284, 285, 302
32Danazol[1] Danazol[1] D00289 [3] AR,
ESR1,
PGR 💬		[12] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, Oocyte meiosis, Pathways in cancer, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[5] 60, 63, 64, 65, 285
33Desmopressin[1] Desmopressin[1] D00291 [2] AVPR2,
F8 💬		[4] Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬[5] 6, 64, 72, 225, 288
34Desmopressin acetate[2] Acetate,
Desmopressin		[1] D00291 [2] AVPR2,
F8 💬		[4] Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬[2] 64, 288
35Dexamethasone[1] Dexamethasone[1] D00292 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[22] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 81, 84, 96, 97, 162, 222, 235, 257, 283, 296, 299
36HMED-IdeS[1] Imlifidase[1] D11470 --[2] 64, 221
37IDEC-C2B8, Ro 45-2294----[1] 64
38IdeS[1] Imlifidase[1] D11470 --[2] 64, 221
39IdeS (0.25 mg/kg)[1] Imlifidase[1] D11470 --[1] 64
40IdeS (0.50 mg/kg)[1] Imlifidase[1] D11470 --[1] 64
41Immunosuppressive treatment (eg, rituximab)[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[1] 64
42MabThera[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[22] 11, 13, 14, 19, 35, 43, 44, 46, 49, 50, 51, 52, 53, 61, 63, 64, 65, 83, 93, 162, 222, 271
43Magnesium[1] Magnesium---[15] 6, 11, 46, 64, 70, 93, 97, 166, 225, 235, 284, 291, 296, 297, 298
44MASP-2 antibody[1] Narsoplimab[1] D11531 [1] MASP2 💬[3] Complement and coagulation cascades, Coronavirus disease - COVID-19, Staphylococcus aureus infection 💬[3] 64, 66, 109
45Methylprednisolone[1] Methylprednisolone[1] D00407 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[46] 2, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296
46Minirin[1] Desmopressin[1] D00291 [2] AVPR2,
F8 💬		[4] Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬[2] 64, 288
47Nanobody directed towards the human A1 domain of von Willebrand factor[1] Von Willebrand factor human---[1] 64
48Octaplas[1] Plasma protein fraction (human)---[1] 64
49Octaplas infusion[1] Plasma protein fraction (human)---[1] 64
50Octaplas SD[1] Plasma protein fraction (human)---[1] 64
51OctaplasLG®----[1] 64
52Octaplas®LG[1] Plasma protein fraction (human)---[1] 64
53Octostim----[2] 64, 288
54OMS721----[3] 64, 66, 109
55OMS721 100 mg/ml Injection solution, OMS00620646, OMS620646, MASP-2 Antibody[1] Narsoplimab[1] D11531 [1] MASP2 💬[3] Complement and coagulation cascades, Coronavirus disease - COVID-19, Staphylococcus aureus infection 💬[2] 64, 109
56OMS721 185 mg/ml Injection solution, OMS00620646, OMS620646, MASP-2 Antibody[1] Narsoplimab[1] D11531 [1] MASP2 💬[3] Complement and coagulation cascades, Coronavirus disease - COVID-19, Staphylococcus aureus infection 💬[2] 64, 109
57Plasma exchange (PE)----[1] 64
58Pooled Plasma (Human), Solvent/Detergent Treated----[1] 64
59PREDNISOLONE[1] Prednisolone[1] D00472 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[42] 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300
60Prednisone[1] Prednisone[1] D00473 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[45] 2, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331
61RADAMTS-13----[1] 64
62Recombinant A Disintegrin and Metalloproteinase Thrombospondin Type-1 Motifs 13----[1] 64
63Recombinant A Disintegrin and Metalloproteinase with Thrombospondin Type-1----[1] 64
64Recombinant A Disintegrin and Metalloproteinase with Thrombospondin Type-1 Motifs----[1] 64
65Recombinant A Disintegrin and Metalloproteinase with Thrombospondin Type-1 Motifs 13----[1] 64
66Recombinant A Disintegrin And Metalloproteinase with Thrombospondin Type-1 Motifs 13 (rADAMTS13)----[1] 64
67Recombinant ADAMTS13----[1] 64
68RITUXIMAB[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[48] 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331
69Romiplostim[1] Romiplostim[1] D08990 [1] MPL 💬[2] Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway 💬[4] 60, 63, 64, 65
70SHP 655 (BAX 930)----[1] 64
71SHP655----[1] 64
72Standard of Care----[8] 6, 13, 49, 51, 63, 64, 79, 171
73Standard Plasma----[1] 64
74Standrd of Care treatment----[1] 64
75Sulfate[1] Sulfate ion---[27] 2, 3, 6, 11, 13, 26, 28, 34, 36, 46, 49, 53, 60, 64, 66, 85, 86, 96, 111, 218, 222, 224, 226, 265, 296, 297, 299
76Sulfate, Magnesium[2] Magnesium,
Sulfate ion		---[1] 64
77TAK-755----[1] 64
78TAK-755 or BAX930 or SHP655----[1] 64
79TAK-755 orBAX930 or SHP655----[1] 64
80Uniplas----[1] 64
81Von willebrand factor[1] Von Willebrand factor human---[2] 64, 288