ACTH ( DrugBank: ACTH )

4 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
13	多発性硬化症／視神経脊髄炎	14
66	IgA腎症	3
145	ウエスト症候群	3
222	一次性ネフローゼ症候群	10

13. 多発性硬化症／視神経脊髄炎

臨床試験数 : 3,340 / 薬物数 : 2,163 - (DrugBank : 383) / 標的遺伝子数 : 241 - 標的パスウェイ数 : 238

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03126760 (ClinicalTrials.gov)	May 22, 2017	4/4/2017	Pilot Study to Assess the Efficacy & Safety of H.P. Acthar® Gel in Subjects With Relapsing-remitting ...	A Multicenter, Randomized, Double Blind, Placebo Controlled Parallel Group, Pilot Study to Assess th ...	Relapsing, Remitting Multiple Sclerosis	Drug: Repository Corticotropin Injection;Drug: Placebo	Mallinckrodt	NULL	Terminated	18 Years	N/A	All	35	Phase 4	United States
2	NCT03021317 (ClinicalTrials.gov)	February 2017	12/1/2017	Effects of ACTHAR on Advanced MRI Surrogate Markers of Disease Activity and on Comprehensive Immune ...	Effects of ACTHAR on Advanced MRI Surrogate Markers of Disease Activity and on Comprehensive Immune ...	Multiple Sclerosis	Drug: ACTHar	University of Chicago	NULL	Not yet recruiting	18 Years	N/A	All	18	Phase 4	NULL
3	NCT02446886 (ClinicalTrials.gov)	June 2016	7/5/2015	Adrenocorticotropic Hormone (ACTH) Effects on Myelination in Subjects With MS	Adrenocorticotropic Hormone (ACTH) Effects on Myelination in Subjects With MS	Multiple Sclerosis	Drug: Adrenocorticotropic hormone (ACTH) gel (H.P. Acthar®)	Weill Medical College of Cornell University	Mallinckrodt	Completed	18 Years	N/A	All	15	Phase 4	United States
4	NCT02315872 (ClinicalTrials.gov)	May 22, 2015	9/12/2014	ACTH for Fatigue in Multiple Sclerosis Patients	The Effect of ACTH(Acthar) on Measures of Chronic Fatigue in Patients With Relapsing Multiple Sclero ...	Multiple Sclerosis, Relapsing-Remitting	Drug: ACTH;Drug: Placebo	Providence Health & Services	Mallinckrodt	Completed	18 Years	65 Years	All	8	Phase 3	United States
5	NCT02258217 (ClinicalTrials.gov)	June 2014	2/10/2014	Tolerability of Acthar for the Treatment of Multiple Sclerosis in Relapses (TAMS)	Tolerability of Acthar for the Treatment of Multiple Sclerosis Relapses (TAMS)	Relapsing Remitting Multiple Sclerosis	Drug: Acthar	OhioHealth	NULL	Completed	18 Years	N/A	All	30	N/A	United States
6	NCT01906684 (ClinicalTrials.gov)	August 2013	19/7/2013	Comprehensive Analysis of Relapse in Multiple Sclerosis	Comprehensive Analysis of Relapse in Multiple Sclerosis	Multiple Sclerosis	Drug: Acthar Gel	Tanner Foundation for Multiple Sclerosis	Questcor Pharmaceuticals, Inc.;Auburn University MRI Research Center;iReportoire Inc	Not yet recruiting	19 Years	65 Years	Both	20	N/A	United States
7	NCT02290444 (ClinicalTrials.gov)	August 2013	23/10/2014	Effects of Acthar on Recovery From Cognitive Relapses in MS	Effects of Adrenocorticotropic Hormone (ACTHAR Gel) on Recovery From Cognitive Relapses in Multiple ...	Multiple Sclerosis	Drug: Adrenocorticotropic Hormone	State University of New York at Buffalo	NULL	Completed	18 Years	65 Years	All	64	Phase 3	United States
8	NCT01900093 (ClinicalTrials.gov)	July 2013	11/7/2013	Evaluation of the Response to Acthar Gel Therapy in Patients Who Failed Intravenous Methylprednisolo ...	An Open-Label Prospective Proof-Of-Concept Trial to Evaluate the Response to Acthar Gel Therapy in P ...	Multiple Sclerosis	Drug: Acthar Gel	Aaron Miller	Mallinckrodt	Recruiting	18 Years	65 Years	All	10	N/A	United States
9	NCT01838174 (ClinicalTrials.gov)	May 2013	18/4/2013	A Trial of Neuroprotection With ACTH in Acute Optic Neuritis	A Phase IV Trial of Neuroprotection With ACTH in Acute Optic Neuritis	Multiple Sclerosis	Drug: ACTHAR Gel (ACTH);Drug: IV methylprednisolone (steroids)	University of Colorado, Denver	Mallinckrodt;University of Pennsylvania	Terminated	18 Years	55 Years	All	100	Phase 4	United States
10	NCT01888354 (ClinicalTrials.gov)	April 2013	16/5/2013	Pilot Clinical Trial of ACTHar Gel 14 Days Subcutaneous (SQ)Versus ACTHar Gel Five Days SQ for the T ...	Pilot Clinical Trial of ACTHar Gel 14 Days Subcutaneous (SQ) Versus ACTHar Gel Five Days SQ for the ...	Multiple Sclerosis (MS)	Drug: H.P. Acthar Gel (repository corticotropin injection)	The University of Texas Health Science Center, Houston	NULL	Completed	18 Years	55 Years	Both	25	Phase 4	United States

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66. IgA腎症

臨床試験数 : 275 / 薬物数 : 258 - (DrugBank : 82) / 標的遺伝子数 : 36 - 標的パスウェイ数 : 140

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2020-001049-38-IT (EUCTR)	24/02/2021	20/05/2021	Study of efficacy and safety of LNP023 in primary IgA nephropathy patients	A multi-center, randomized, double-blind, placebo-controlled, parallelgroup, phase III study to eval ...	IgA Nephropathy MedDRA version: 20.0;Level: PT;Classification code 10021263;Term: IgA nephropathy;Sy ...	Trade Name: ACTHIB - POLVERE E SOLVENTE PER SOLUZIONE INIETTABILE 1 FLACONCINO POLVERE+1 SIRINGA PRE ...	NOVARTIS PHARMA AG	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	450	Phase 3	United States;Taiwan;Spain;Thailand;Russian Federation;Israel;Colombia;Italy;India;Vietnam;France;Ma ...
2	NCT02282930 (ClinicalTrials.gov)	March 2015	31/10/2014	Pilot Study of ACTHin the Treatment of Immunoglobulin A (IgA) Nephropathy at High Risk of Progressio ...	An Open-Label Pilot Study of ACTH in the Treatment of IgA Nephropathy at High Risk of Progression	Progressive IgA Nephropathy;Proteinuria	Drug: ACTH (Acthar) Gel	Mayo Clinic	Mallinckrodt	Completed	18 Years	N/A	All	20	Phase 3	United States
3	NCT02382523 (ClinicalTrials.gov)	February 2015	9/1/2015	Acthar on Proteinuria in IgA Nephropathy Patients	Impact of Acthar on Proteinuria and Disease Progression in IgA Nephropathy Patients With Nephrotic R ...	IgA Nephropathy;Proteinuria	Drug: Acthar 80 unit injection	Baylor College of Medicine	NULL	Withdrawn	18 Years	N/A	All	0	Phase 4	United States

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145. ウエスト症候群

臨床試験数 : 43 / 薬物数 : 52 - (DrugBank : 15) / 標的遺伝子数 : 28 - 標的パスウェイ数 : 26

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05279118 (ClinicalTrials.gov)	March 1, 2022	3/3/2022	Ketogenic Diet vs ACTH for the Treatment of Children With West Syndrome	Comparison of Efficacy of Ketogenic Diet and ACTHTherapy Among Children With West Syndrome: A Pilot ...	Ketogenic Diet;West Syndrome;Infantile Spasm;ACTH	Dietary Supplement: Ketogenic diet;Drug: ACTH	All India Institute of Medical Sciences, New Delhi	NULL	Recruiting	6 Months	2 Years	All	80	Phase 2/Phase 3	India
2	NCT02092883 (ClinicalTrials.gov)	March 2013	14/3/2014	Evaluation of Neuroinflammation in Children With Infantile Spasms	Neuroinflammation in Children With Infantile Spasms Measured With 11C-PK11195 Positron Emission Tomo ...	Infantile Spasms	Drug: ACTH	Wayne State University	NULL	Completed	N/A	N/A	All	8	Phase 4	United States
3	NCT01367964 (ClinicalTrials.gov)	July 2011	3/6/2011	Prevention of West Syndrome With Low-dose Adrenocorticotropin Hormone (ACTH)	Early Treatment of Infants at High Risk of Developing West Syndrome With Low-dose Adrenocorticotropi ...	West Syndrome	Drug: adrenocorticotropin hormone	Ann & Robert H Lurie Children's Hospital of Chicago	Thrasher Research Fund	Unknown status	2 Months	12 Months	All	28	N/A	United States

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222. 一次性ネフローゼ症候群

臨床試験数 : 310 / 薬物数 : 295 - (DrugBank : 117) / 標的遺伝子数 : 63 - 標的パスウェイ数 : 194

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02399462 (ClinicalTrials.gov)	March 2021	8/1/2015	Acthar for Treatment of Post-transplant FSGS	Acthar for Treatment of Post-transplant FSGS	FSGS;Renal Transplantation;Kidney Transplantation	Drug: Acthar	University of North Carolina, Chapel Hill	Mallinckrodt	Withdrawn	18 Years	N/A	All	0	Phase 4	United States
2	NCT02683889 (ClinicalTrials.gov)	February 1, 2019	5/2/2016	Use of Acthar in Patients With FSGS That Will be Undergoing Renal Transplantation	The Use of Acthar (ACTH) in Patients With Focal Segmental Glomerulosclerosis (FSGS) Who Have Develop ...	FSGS	Drug: Acthar	University of Colorado, Denver	NULL	Recruiting	18 Years	80 Years	All	20	Phase 3	United States
3	NCT03025828 (ClinicalTrials.gov)	March 19, 2018	17/1/2017	Adrenocorticotropic Hormone in Membranous Nephropathy	Changes in Autoreactive Memory B Cells as Biomarker of Response to Adrenocorticotropic Hormone in Pa ...	Membranous Nephropathy	Drug: ACTHar	Icahn School of Medicine at Mount Sinai	NULL	Completed	18 Years	70 Years	All	5	Phase 4	United States
4	NCT02633046 (ClinicalTrials.gov)	October 10, 2016	15/12/2015	Acthar for Treatment-Resistant or Treatment-Intolerant Proteinuria	Treatment of Proteinuria Due to Treatment Resistant or Treatment Intolerant Idiopathic Focal Segment ...	Idiopathic Focal Segmental Glomerulosclerosis	Drug: Acthar Gel	Mallinckrodt ARD LLC	NULL	Completed	18 Years	N/A	All	63	Phase 4	United States;Argentina;Australia;Chile;Mexico;Peru;Turkey;Canada;Hong Kong;New Zealand;Puerto Rico
5	NCT01386554 (ClinicalTrials.gov)	August 2011	29/6/2011	Acthar for Treatment of Proteinuria in Membranous Nephropathy Patients	A Randomized, Placebo-Controlled, Parallel-Group, Double-Blind Study of H.P. Acthar Gel (Acthar) in ...	Proteinuria;Idiopathic Membranous Nephropathy	Drug: Repository Corticotropin Injection;Drug: Placebo	Mallinckrodt	NULL	Completed	18 Years	N/A	All	60	Phase 4	United States;Canada;Chile;Mexico;Turkey
6	NCT01093157 (ClinicalTrials.gov)	February 2010	24/3/2010	A Dose Escalation Study of Long-acting ACTH Gel in Membranous Nephropathy	A Dose-finding Pilot Study of ACTH(Adrenocorticotropic Hormone) on the Proteinuria and Serum Lipopro ...	Glomerulonephritis	Drug: Adrenocorticotrophic hormone ACTH	University Health Network, Toronto	Mallinckrodt	Completed	18 Years	72 Years	All	10	Phase 1/Phase 2	Canada
7	NCT01155141 (ClinicalTrials.gov)	September 2009	29/6/2010	Idiopathic Focal Segmental Glomerulosclerosis (FSGS) and Treatment With ACTH	Idiopathic Focal Segmental Glomerulosclerosis (FSGS) and Treatment With ACTH	Kidney Diseases	Drug: H.P. Acthar Gel	Stanford University	Mallinckrodt	Completed	16 Years	65 Years	All	15	Phase 4	United States
8	NCT00805753 (ClinicalTrials.gov)	January 2009	9/12/2008	Dose-Finding Pilot Study of ACTH in Patients With Idiopathic Membranous Nephropathy	A Dose-Finding Pilot Study of ACTHon the Serum Lipoprotein Profile and Proteinuria in Patients With ...	Idiopathic Membranous Nephropathy	Drug: ACTH	Mayo Clinic	Questcor Pharmaceuticals, Inc.	Completed	18 Years	N/A	Both	20	Phase 1	United States;Canada
9	NCT00694863 (ClinicalTrials.gov)	July 2008	9/6/2008	Treatment With Synthetic ACTH in High Risk Patients With Membranous Nephropathy	Treatment With Synthetic Adrenocorticotropic Hormone (ACTH) in Patients With Membranous Nephropathy ...	Idiopathic Membranous Nephropathy	Drug: tetracosactide hexacetaat	Radboud University	Dutch Kidney Foundation	Completed	18 Years	95 Years	Both	20	Phase 2	Netherlands
10	EUCTR2008-001647-19-NL (EUCTR)	22/05/2008	04/06/2008	Treatment with synthetic adrenocoticotropic hormone (ACTH) in patients with membranous nephropathy a ...	Treatment with synthetic adrenocoticotropic hormone (ACTH) in patients with membranous nephropathy a ...	Membranous nephropathy MedDRA version: 9.1;Level: LLT;Classification code 10027170;Term: Membranous ...	Trade Name: Synacthen Depot 1mg	Radboud University Nijmegen Medical Center	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes			Netherlands

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