Pentoxifylline ( DrugBank: Pentoxifylline )

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10 diseases

ID	Disease name (Link within this page)	Number of trials
26	HTLV-1-associated myelopathy	1
56	Behcet disease	2
84	Sarcoidosis	1
93	Primary biliary cholangitis	1
96	Crohn disease	1
113	Muscular dystrophy	2
220	Rapidly progressive glomerulonephritis	1
222	Primary nephrotic syndrome	1
296	Biliary atresia	1
298	Hereditary pancreatitis	1

26. HTLV-1-associated myelopathy

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Clinical trials : 28 /  Drugs : 48 - (DrugBank : 28) / Drug target genes : 38 - Drug target pathways : 127

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01472263 (ClinicalTrials.gov)	September 2009	11/11/2011	Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases	Effectiveness of Pentoxifylline in Attenuating Neurological Disease Associated With HTLV-1 and Negative Modulator of Pathological Immune Response.	HTLV-1;Tropical Spastic Paraparesis;Immune System Diseases;Physical Disability;Pentoxifylline	Drug: Pentoxifylline;Drug: Placebo	Hospital Universitário Professor Edgard Santos	NULL	Completed	18 Years	80 Years	Both	48	Phase 3	Brazil

56. Behcet disease

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Clinical trials : 76 /  Drugs : 110 - (DrugBank : 32) / Drug target genes : 36 - Drug target pathways : 116

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04186559 (ClinicalTrials.gov)	February 2020	2/12/2019	Topical Pentoxifylline Gel on Behcet's Disease Genital Ulcers	Clinical Protocol to Evaluate Use of Topical Pentoxifylline Gel on Behcet's Disease Genital Ulcers	Behcet Syndrome;Behcet Disease	Drug: Topical Pentoxifylline Gel (Vehicle +PTX);Drug: Topical Placebo Gel (Vehicle)	Silk Road Therapies, Inc.	NULL	Not yet recruiting	18 Years	N/A	All	60	Phase 2	United States
2	NCT03888846 (ClinicalTrials.gov)	March 25, 2019	21/3/2019	Topical Pentoxifylline Gel on Behcet's Disease Oral Ulcers	Clinical Protocol for Administration of Topical Pentoxifylline Gel on Behcet's Disease Oral Ulcers	Behçet Disease Affecting Oral Mucosa	Drug: Pentoxifylline;Drug: Colchicine	Ipekyolu Ilac Ltd. Sti	Istanbul University-Cerrahpasa School of Medicine	Recruiting	18 Years	N/A	All	60	Phase 2	Turkey

84. Sarcoidosis

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Clinical trials : 149 /  Drugs : 227 - (DrugBank : 81) / Drug target genes : 82 - Drug target pathways : 167

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00001877 (ClinicalTrials.gov)	February 1999	3/11/1999	Treatment of Pulmonary Sarcoidosis With Pentoxifylline	Treatment of Pulmonary Sarcoidosis With Pentoxifylline	Pulmonary Sarcoidosis	Drug: Pentoxifylline	National Heart, Lung, and Blood Institute (NHLBI)	NULL	Completed	N/A	N/A	Both	100	Phase 2	United States

93. Primary biliary cholangitis

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Clinical trials : 282 /  Drugs : 245 - (DrugBank : 56) / Drug target genes : 35 - Drug target pathways : 113

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01249092 (ClinicalTrials.gov)	November 2010	24/11/2010	Pentoxifylline for Primary Biliary Cirrhosis	A Pilot Study of Pentoxifylline for the Treatment of Primary Biliary Cirrhosis	Primary Biliary Cirrhosis	Drug: Pentoxifylline	The Cleveland Clinic	NULL	Completed	18 Years	76 Years	All	20	Phase 2	United States

96. Crohn disease

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Clinical trials : 2,400 /  Drugs : 1,391 - (DrugBank : 267) / Drug target genes : 170 - Drug target pathways : 215

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02953275 (ClinicalTrials.gov)	April 13, 2017	31/10/2016	Synergistic Effect of Vedolizumab and Pentoxifylline	Synergistic Effect of Vedolizumab and Pentoxifylline in the Management of Patients With Inflammatory Bowel Disease	Crohn Disease	Drug: vedolizumab;Drug: Pentoxifylline;Drug: placebo	University of Miami	Takeda	Completed	18 Years	80 Years	All	37	Early Phase 1	United States

113. Muscular dystrophy

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Clinical trials : 622 /  Drugs : 485 - (DrugBank : 99) / Drug target genes : 59 - Drug target pathways : 168

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00243789 (ClinicalTrials.gov)	September 2005	21/10/2005	Study of Daily Pentoxifylline as a Rescue Treatment in Duchenne Muscular Dystrophy	A Double-Blinded Randomized Placebo Controlled Study of Daily Pentoxifylline as a Rescue Treatment in DMD	Muscular Dystrophy, Duchenne	Drug: Pentoxifylline	Cooperative International Neuromuscular Research Group	NULL	Completed	7 Years	N/A	Male	64	Phase 1/Phase 2	United States;Argentina;Australia;Canada;Israel;Italy
2	NCT00102453 (ClinicalTrials.gov)	March 2002	29/1/2005	Pentoxifylline in Duchenne Muscular Dystrophy	An Open-Label Pilot Study of Pentoxifylline in Steroid-naive Duchenne Muscular Dystrophy	Muscular Dystrophy, Duchenne	Drug: Pentoxifylline	Cooperative International Neuromuscular Research Group	NULL	Completed	4 Years	7 Years	Male	17	Phase 1/Phase 2	United States

220. Rapidly progressive glomerulonephritis

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Clinical trials : 2 /  Drugs : 5 - (DrugBank : 2) / Drug target gene : 1 - Drug target pathway : 1

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00354198 (ClinicalTrials.gov)	August 2006	18/7/2006	Efficacy of Pentoxifylline on Rapidly Progressive Glomerulonephritis	Clinical Efficacy of Combined Pentoxifylline and Conventional Immunosuppressive Regimens on Patients With Rapidly Progressive Glomerulonephritis	Glomerulonephritis	Drug: pentoxifylline;Drug: corticosteroids	National Taiwan University Hospital	National Science Council, Taiwan	Terminated	20 Years	80 Years	Both	7	Phase 3	Taiwan

222. Primary nephrotic syndrome

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Clinical trials : 285 /  Drugs : 285 - (DrugBank : 108) / Drug target genes : 62 - Drug target pathways : 191

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00354731 (ClinicalTrials.gov)	August 2006	18/7/2006	Efficacy of Pentoxifylline on Primary Nephrotic Syndrome	Clinical Efficacy of Pentoxifylline on Patients With Primary Nephrotic Syndrome	Nephrotic Syndrome	Drug: pentoxifylline;Drug: Corticosteroid	National Taiwan University Hospital	National Science Council, Taiwan	Completed	20 Years	80 Years	Both	62	Phase 3	Taiwan

296. Biliary atresia

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Clinical trials : 63 /  Drugs : 65 - (DrugBank : 37) / Drug target genes : 45 - Drug target pathways : 63

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01774487 (ClinicalTrials.gov)	January 2013	22/1/2013	Pentoxifylline Therapy in Biliary Atresia	A Phase II Trial of Pentoxifylline in Newly-Diagnosed Biliary Atresia	Biliary Atresia	Drug: Pentoxifylline	Baylor College of Medicine	NULL	Recruiting	N/A	180 Days	All	60	Phase 2	United States

298. Hereditary pancreatitis

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Clinical trials : 98 /  Drugs : 180 - (DrugBank : 57) / Drug target genes : 53 - Drug target pathways : 142

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02487225 (ClinicalTrials.gov)	May 2015	29/6/2015	Pentoxifylline Treatment in Acute Pancreatitis (AP)	Pentoxifylline Treatment in Acute Pancreatitis: A Double-Blind Placebo - Controlled Randomized Trial	Acute Pancreatitis (AP);Gallstone Pancreatitis;Alcoholic Pancreatitis;Trauma Acute Pancreatitis;Hypertriglyceridemia Acute Pancreatitis;Idiopathic (Unknown) Acute Pancreatitis;Medication Induced Acute Pancreatitis;Cancer Acute Pancreatitis;Miscellaneous (i.e. Acute on Chronic Pancreatitis)	Drug: Pentoxifylline;Drug: Placebo	Mayo Clinic	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Completed	18 Years	100 Years	All	83	Phase 3	United States

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