DDrare
Disease
Drug
Target Gene/Pathway
問合せ先
EN
Target Gene/Pathway
Pathway
/
Gene
Search
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Other
Search results
10
50
100
ALL
entries per page:
Showing 1 to 10 of 26 entries
Filter by
Reset
|
No.
KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
指定難病告示番号
1
TNFRSF13C
💬
1. TNFRSF13C
×
Name
Full Name
TNFRSF13C
TNF receptor superfamily member 13C
5件:
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
NF-kappa B signaling pathway
,
Intestinal immune network for IgA production
,
Human T-cell leukemia virus 1 infection
,
Primary immunodeficiency
5件:
Cytokine-cytokine receptor interaction
,
NF-kappa B signaling pathway
,
Intestinal immune network
...
Ianalumab
Ianalumab
💬
1. TNFRSF13C
×
Name
Other Names
Ianalumab
Ianalumab (USAN/INN)
アイアナルマブ
イアナルマブ
Ianalumab
7件:
35
35
,
46
,
49
,
53
,
61
,
63
,
95
💬
1. TNFRSF13C
×
告示番号
日本語名
英語名
35
天疱瘡
Pemphigus
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
53
シェーグレン症候群
Sjogren syndrome
61
自己免疫性溶血性貧血
Autoimmune hemolytic anemia
63
特発性血小板減少性紫斑病;一次性免疫性血小板減少症
Idiopathic thrombocytopenic purpura
95
自己免疫性肝炎
Autoimmune hepatitis
2
IL2RG
💬
2. IL2RG
×
Name
Full Name
IL2RG
interleukin 2 receptor subunit gamma
12件:
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine receptor
,
Endocytosis
,
PI3K-Akt signaling pathway
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Measles
,
Human T-cell leukemia virus 1 infection
,
Pathways in cancer
,
Inflammatory bowel disease
,
Primary immunodeficiency
12件:
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine re
...
Aldesleukin
Aldesleukin
💬
2. IL2RG
×
Name
Other Names
Aldesleukin
Aldesleukin (USAN/INN)
Interleukin-2
Proleukin (TN)
アルデスロイキン
インターロイキン-2
Aldesleukin
6件:
2
2
,
35
,
49
,
65
,
96
,
97
💬
2. IL2RG
×
告示番号
日本語名
英語名
2
筋萎縮性側索硬化症
Amyotrophic lateral sclerosis
35
天疱瘡
Pemphigus
49
全身性エリテマトーデス
Systemic lupus erythematosus
65
原発性免疫不全症候群
Primary immunodeficiency
96
クローン病;回腸末端炎
Crohn disease
97
潰瘍性大腸炎
Ulcerative colitis
3
JAK3
💬
3. JAK3
×
Name
Full Name
JAK3
Janus kinase 3
15件:
Chemokine signaling pathway
Chemokine signaling pathway
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Signaling pathways regulating pluripotency of stem cells
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Hepatitis B
,
Measles
,
Human T-cell leukemia virus 1 infection
,
Epstein-Barr virus infection
,
Pathways in cancer
,
Viral carcinogenesis
,
Non-small cell lung cancer
,
Primary immunodeficiency
15件:
Chemokine signaling pathway
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Signaling pathways regula
...
Tofacitinib
Tofacitinib
💬
3. JAK3
×
Name
Other Names
Tofacitinib
Tofacitinib (USAN)
Tasocitinib
トファシチニブ
タソシチニブ
Tofacitinib
15件:
11
11
,
40
,
44
,
46
,
49
,
50
,
51
,
53
,
65
,
84
,
96
,
97
,
107
,
271
,
300
💬
3. JAK3
×
告示番号
日本語名
英語名
11
重症筋無力症
Myasthenia gravis
40
高安動脈炎;大動脈炎症候群
Takayasu arteritis
44
多発血管炎性肉芽腫症;ウェゲナー肉芽腫症
Wegener granulomatosis
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
50
皮膚筋炎／多発性筋炎
Dermatomyositis
51
全身性強皮症
Scleroderma
53
シェーグレン症候群
Sjogren syndrome
65
原発性免疫不全症候群
Primary immunodeficiency
84
サルコイドーシス
Sarcoidosis
96
クローン病;回腸末端炎
Crohn disease
97
潰瘍性大腸炎
Ulcerative colitis
107
若年性特発性関節炎
Juvenile idiopathic arthritis
271
強直性脊椎炎
Ankylosing spondylitis
300
IgG4関連疾患
IgG4-related disease
4
JAK3
💬
4. JAK3
×
Name
Full Name
JAK3
Janus kinase 3
15件:
Chemokine signaling pathway
Chemokine signaling pathway
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Signaling pathways regulating pluripotency of stem cells
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Hepatitis B
,
Measles
,
Human T-cell leukemia virus 1 infection
,
Epstein-Barr virus infection
,
Pathways in cancer
,
Viral carcinogenesis
,
Non-small cell lung cancer
,
Primary immunodeficiency
15件:
Chemokine signaling pathway
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Signaling pathways regula
...
Peficitinib
Peficitinib
💬
4. JAK3
×
Name
Other Names
Peficitinib
Peficitinib (USAN/INN)
ペフィシチニブ
Peficitinib
1件:
46
46
💬
4. JAK3
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
5
LCK
💬
5. LCK
×
Name
Full Name
LCK
LCK proto-oncogene, Src family tyrosine kinase
10件:
NF-kappa B signaling pathway
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Yersinia infection
,
Human T-cell leukemia virus 1 infection
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Primary immunodeficiency
10件:
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Natural killer cell mediated cytotoxi
...
Dasatinib
Dasatinib
💬
5. LCK
×
Name
Other Names
Dasatinib
Dasatinib (JAN/INN)
ダサチニブ
Dasatinib
2件:
51
51
,
85
💬
5. LCK
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
6
LCK
💬
6. LCK
×
Name
Full Name
LCK
LCK proto-oncogene, Src family tyrosine kinase
10件:
NF-kappa B signaling pathway
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Yersinia infection
,
Human T-cell leukemia virus 1 infection
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Primary immunodeficiency
10件:
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Natural killer cell mediated cytotoxi
...
Dasatinib
Dasatinib
💬
6. LCK
×
Name
Other Names
Dasatinib
Dasatinib (USAN)
Dasatinib hydrate (JAN)
Sprycel (TN)
ダサチニブ水和物
スプリセル
Dasatinib
2件:
51
51
,
85
💬
6. LCK
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
7
BTK
💬
7. BTK
×
Name
Full Name
BTK
Bruton tyrosine kinase
7件:
NF-kappa B signaling pathway
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Platelet activation
,
B cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Epstein-Barr virus infection
,
Primary immunodeficiency
7件:
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Platelet activation
,
B cell receptor s
...
Ibrutinib
Ibrutinib
💬
7. BTK
×
Name
Other Names
Ibrutinib
Ibrutinib (JAN/USAN)
Imbruvica (TN)
イブルチニブ
イムブルビカ
Ibrutinib
3件:
28
28
,
60
,
61
💬
7. BTK
×
告示番号
日本語名
英語名
28
全身性アミロイドーシス
Systemic amyloidosis
60
再生不良性貧血
Aplastic anemia
61
自己免疫性溶血性貧血
Autoimmune hemolytic anemia
8
BTK
💬
8. BTK
×
Name
Full Name
BTK
Bruton tyrosine kinase
7件:
NF-kappa B signaling pathway
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Platelet activation
,
B cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Epstein-Barr virus infection
,
Primary immunodeficiency
7件:
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Platelet activation
,
B cell receptor s
...
Acalabrutinib
Acalabrutinib
💬
8. BTK
×
Name
Other Names
Acalabrutinib
Acalabrutinib (JAN/USAN/INN)
Calquence (TN)
アカラブルチニブ
カルケンス
Acalabrutinib
2件:
46
46
,
61
💬
8. BTK
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
61
自己免疫性溶血性貧血
Autoimmune hemolytic anemia
9
BTK
💬
9. BTK
×
Name
Full Name
BTK
Bruton tyrosine kinase
7件:
NF-kappa B signaling pathway
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Platelet activation
,
B cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Epstein-Barr virus infection
,
Primary immunodeficiency
7件:
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Platelet activation
,
B cell receptor s
...
Zanubrutinib
Zanubrutinib
💬
9. BTK
×
Name
Other Names
Zanubrutinib
Zanubrutinib (JAN/USAN/INN)
Brukinsa (TN)
ザヌブルチニブ
Zanubrutinib
5件:
13
13
,
63
,
222
,
300
,
331
💬
9. BTK
×
告示番号
日本語名
英語名
13
多発性硬化症／視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
63
特発性血小板減少性紫斑病;一次性免疫性血小板減少症
Idiopathic thrombocytopenic purpura
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
300
IgG4関連疾患
IgG4-related disease
331
特発性多中心性キャッスルマン病
Idiopathic multicentric castleman disease
10
BTK
💬
10. BTK
×
Name
Full Name
BTK
Bruton tyrosine kinase
7件:
NF-kappa B signaling pathway
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Platelet activation
,
B cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Epstein-Barr virus infection
,
Primary immunodeficiency
7件:
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Platelet activation
,
B cell receptor s
...
Fenebrutinib
Fenebrutinib
💬
10. BTK
×
Name
Other Names
Fenebrutinib
Fenebrutinib (USAN/INN)
フェネブルチニブ
Fenebrutinib
1件:
13
13
💬
10. BTK
×
告示番号
日本語名
英語名
13
多発性硬化症／視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica