Target Gene/Pathway Pathway / Gene
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No. | KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related | KEGG GENES | KEGG DRUG | DrugBank | 指定難病告示番号 |
---|---|---|---|---|---|
1 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
BRAF 1件: BRAF 💬 |
D10064 D10064 💬 |
Dabrafenib | 034 1件: 34 💬 |
2 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
BRAF 2件: BRAF, RAF1 💬 |
D08524 D08524 💬 |
Sorafenib | 034 2件: 34, 86 💬 |
3 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D03455 D03455 💬 |
Cetuximab | 051 2件: 51, 86 💬 |
4 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D07907 D07907 💬 |
Erlotinib | 094 1件: 94 💬 |
5 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D01977 D01977 💬 |
Gefitinib | 075 1件: 75 💬 |
6 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D11251 D11251 💬 |
Icotinib | 034 1件: 34 💬 |
7 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D08108 D08108 💬 |
Lapatinib | 034 3件: 34, 74, 75 💬 |
8 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D08950 D08950 💬 |
Neratinib | 034 1件: 34 💬 |
9 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D11772 D11772 💬 |
Tesevatinib | 067 1件: 67 💬 |
10 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
IGF1R 1件: IGF1R 💬 |
D09925 D09925 💬 |
Linsitinib | 232 1件: 232 💬 |
11 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
IGF1R 1件: IGF1R 💬 |
D03297 D03297 💬 |
Mecasermin | 065 6件: 65, 78, 96, 168, 265, 299 💬 |
12 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
IGF1R 1件: IGF1R 💬 |
D09680 D09680 💬 |
Teprotumumab | 051 1件: 51 💬 |
13 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
IL10 2件: IL10, IL6 💬 |
D01583 D01583 💬 |
Pirfenidone | 013 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 |
14 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
IL6 1件: IL6 💬 |
D12487 D12487 💬 |
Olokizumab | 046 2件: 46, 96 💬 |
15 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
IL6 1件: IL6 💬 |
D08976 D08976 💬 |
Pomalidomide | 028 5件: 28, 51, 85, 227, 331 💬 |
16 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
IL6 1件: IL6 💬 |
D09669 D09669 💬 |
Siltuximab | 028 2件: 28, 331 💬 |
17 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
IL6 1件: IL6 💬 |
D10080 D10080 💬 |
Sirukumab | 041 2件: 41, 46 💬 |
18 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
INSR 1件: INSR 💬 |
D04539 D04539 💬 |
Insulin detemir | 299 1件: 299 💬 |
19 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
INSR 1件: INSR 💬 |
D03250 D03250 💬 |
Insulin glargine | 299 1件: 299 💬 |
20 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
INSR 1件: INSR 💬 |
D03230 D03230 💬 |
Insulin human | 096 2件: 96, 156 💬 |
21 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10604 D10604 💬 |
Binimetinib | 034 1件: 34 💬 |
22 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10405 D10405 💬 |
Cobimetinib | 280 1件: 280 💬 |
23 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D11675 D11675 💬 |
Mirdametinib | 034 1件: 34 💬 |
24 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D09666 D09666 💬 |
Selumetinib | 034 1件: 34 💬 |
25 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10175 D10175 💬 |
Trametinib | 002 4件: 2 , 34, 279, 280 💬 |
26 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
MAPK11 4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 |
D09639 D09639 💬 |
Losmapimod | 113 2件: 113, 222 💬 |
27 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
MAPK11 4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 |
D10959 D10959 💬 |
Neflamapimod | 008 1件: 8 💬 |
28 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
PIK3CA 1件: PIK3CA 💬 |
D11011 D11011 💬 |
Alpelisib | 138 1件: 138 💬 |
29 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
PIK3CA 3件: PIK3CA, PIK3CB, PIK3CD 💬 |
D11158 D11158 💬 |
Leniolisib | 053 2件: 53, 65 💬 |
30 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
PIK3CD 1件: PIK3CD 💬 |
D11437 D11437 💬 |
Parsaclisib | 035 3件: 35, 53, 61 💬 |
31 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
PLK1 1件: PLK1 💬 |
D10154 D10154 💬 |
Rigosertib | 036 1件: 36 💬 |
32 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
PRKAA1 2件: PRKAA1, PRKAA2 💬 |
D04966 D04966 💬 |
Metformin | 002 25件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 |
33 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
S1PR1 1件: S1PR1 💬 |
D11283 D11283 💬 |
Cenerimod | 049 1件: 49 💬 |
34 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
S1PR1 1件: S1PR1 💬 |
D10001 D10001 💬 |
Fingolimod | 013 3件: 13, 14, 156 💬 |
35 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
S1PR1 1件: S1PR1 💬 |
D11215 D11215 💬 |
Ponesimod | 013 1件: 13 💬 |
36 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
S1PR1 1件: S1PR1 💬 |
D11460 D11460 💬 |
Siponimod | 013 2件: 13, 50 💬 |
37 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
S1PR1 2件: S1PR1, S1PR4 💬 |
D10905 D10905 💬 |
Amiselimod | 097 1件: 97 💬 |
38 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
S1PR1 2件: S1PR1, S1PR4 💬 |
D10930 D10930 💬 |
Etrasimod | 096 3件: 96, 97, 98 💬 |
39 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
S1PR1 2件: S1PR1, S1PR4 💬 |
D10968 D10968 💬 |
Ozanimod | 013 3件: 13, 96, 97 💬 |
40 | FoxO signaling pathway 💬 Related to 24 target genes, 40 drugs (DrugBank) and 54 diseases in DDrare |
TGFB1 3件: TGFB1, TGFB2, TGFB3 💬 |
D09620 D09620 💬 |
Fresolimumab | 051 3件: 51, 85, 222 💬 |