Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Serotonergic synapse 💬
1件: ALOX5 💬 D01773 💬 Oxatomide 1件: 113 💬
2 Serotonergic synapse 💬
1件: ALOX5 💬 D00414 💬 Zileuton 3件: 85, 160, 164 💬
3 Serotonergic synapse 💬
1件: BRAF 💬 D10064 💬 Dabrafenib 1件: 34 💬
4 Serotonergic synapse 💬
2件: BRAF, RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
5 Serotonergic synapse 💬
5件: CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine 1件: 67 💬
6 Serotonergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine 4件: 13, 51, 67, 298 💬
7 Serotonergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem 3件: 51, 58, 86 💬
8 Serotonergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine 1件:  6  💬
9 Serotonergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine 2件: 70, 86 💬
10 Serotonergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine 2件: 50, 81 💬
11 Serotonergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine 1件: 90 💬
12 Serotonergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline 2件: 58, 272 💬
13 Serotonergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08441 💬 Propiverine 1件: 226 💬
14 Serotonergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil 4件: 58, 96, 140, 167 💬
15 Serotonergic synapse 💬
7件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3 💬 D00537 💬 Topiramate 6件:  6 , 97, 140, 144, 156, 193 💬
16 Serotonergic synapse 💬
1件: DDC 💬 D03082 💬 Benserazide 1件:  6  💬
17 Serotonergic synapse 💬
1件: DDC 💬 D00558 💬 Carbidopa 7件:  6 , 13, 17, 90, 140, 164, 201 💬
18 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D00225 💬 Alprazolam 2件:  8 , 75 💬
19 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D11149 💬 Brexanolone 1件: 205 💬
20 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D01253 💬 Clobazam 2件: 140, 144 💬
21 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D00280 💬 Clonazepam 1件:  6  💬
22 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D07784 💬 Delorazepam 3件:  6 , 46, 97 💬
23 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D00293 💬 Diazepam 3件: 46, 155, 298 💬
24 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D02624 💬 Eszopiclone 3件:  6 , 13, 46 💬
25 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D00697 💬 Flumazenil 5件:  6 , 13, 17, 18, 206 💬
26 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D04282 💬 Gaboxadol 2件: 201, 206 💬
27 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D04300 💬 Ganaxolone 4件: 145, 152, 158, 206 💬
28 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D00365 💬 Lorazepam 1件: 36 💬
29 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D00550 💬 Midazolam 12件:  2 ,  3 ,  6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
30 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D00549 💬 Propofol 9件:  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
31 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D08690 💬 Zolpidem 3件:  5 ,  6 , 46 💬
32 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D01372 💬 Zopiclone 1件:  6  💬
33 Serotonergic synapse 💬
1件: HTR1A 💬 D07593 💬 Buspirone 2件:  6 , 51 💬
34 Serotonergic synapse 💬
1件: HTR1A 💬 D09397 💬 Pardoprunox 1件:  6  💬
35 Serotonergic synapse 💬
2件: HTR1A, HTR2A 💬 D01164 💬 Aripiprazole 2件:  6 , 206 💬
36 Serotonergic synapse 💬
2件: HTR1A, HTR2A 💬 D09997 💬 Cariprazine 1件: 21 💬
37 Serotonergic synapse 💬
7件: HTR1A, HTR3A, HTR3B, HTR3C, HTR3D, HTR3E, SLC6A4 💬 D10184 💬 Vortioxetine 1件:  6  💬
38 Serotonergic synapse 💬
2件: HTR1B, HTR1D 💬 D00415 💬 Zolmitriptan 1件:  6  💬
39 Serotonergic synapse 💬
4件: HTR1D, HTR2A, HTR2C, SLC6A4 💬 D07945 💬 Fenfluramine 4件: 140, 144, 145, 149 💬
40 Serotonergic synapse 💬
1件: HTR2A 💬 D09645 💬 Nelotanserin 1件:  6  💬
41 Serotonergic synapse 💬
1件: HTR2A 💬 D08456 💬 Quetiapine 2件:  6 , 13 💬
42 Serotonergic synapse 💬
1件: HTR2A 💬 D00426 💬 Risperidone 5件:  8 , 156, 179, 187, 206 💬
43 Serotonergic synapse 💬
3件: HTR2A, HTR2B, HTR2C 💬 D00270 💬 Chlorpromazine 1件: 254 💬
44 Serotonergic synapse 💬
3件: HTR2A, HTR2B, HTR2C 💬 D02666 💬 Iloperidone 1件:  6  💬
45 Serotonergic synapse 💬
4件: HTR2A, HTR2B, HTR2C, HTR6 💬 D00454 💬 Olanzapine 2件:  2 ,  8  💬
46 Serotonergic synapse 💬
4件: HTR2A, HTR2B, HTR2C, SLC6A4 💬 D08626 💬 Trazodone 1件:  2  💬
47 Serotonergic synapse 💬
7件: HTR2A, HTR2C, HTR3A, HTR3B, HTR3C, HTR3D, HTR3E 💬 D00283 💬 Clozapine 1件:  6  💬
48 Serotonergic synapse 💬
3件: HTR2A, HTR3A, HTR4 💬 D00274 💬 Cisapride 1件: 13 💬
49 Serotonergic synapse 💬
3件: HTR2A, HTR3A, HTR4 💬 D02092 💬 Cisapride 1件: 13 💬
50 Serotonergic synapse 💬
1件: HTR2C 💬 D02578 💬 Agomelatine 1件:  6  💬
51 Serotonergic synapse 💬
5件: HTR3A, HTR3B, HTR3C, HTR3D, HTR3E 💬 D07867 💬 Dolasetron 1件: 46 💬
52 Serotonergic synapse 💬
5件: HTR3A, HTR3B, HTR3C, HTR3D, HTR3E 💬 D00456 💬 Ondansetron 3件:  6 , 97, 107 💬
53 Serotonergic synapse 💬
1件: HTR4 💬 D08236 💬 Mosapride 1件: 96 💬
54 Serotonergic synapse 💬
1件: HTR4 💬 D09205 💬 Prucalopride 3件: 13, 51, 96 💬
55 Serotonergic synapse 💬
1件: HTR4 💬 D09693 💬 Velusetrag 1件: 99 💬
56 Serotonergic synapse 💬
1件: KCND2 💬 D10228 💬 Amifampridine 3件:  3 , 11, 12 💬
57 Serotonergic synapse 💬
1件: KCND2 💬 D04127 💬 Dalfampridine 5件:  3 ,  4 ,  6 , 13, 14 💬
58 Serotonergic synapse 💬
2件: KCNJ3, KCNJ5 💬 D02910 💬 Amiodarone 2件: 28, 127 💬
59 Serotonergic synapse 💬
1件: MAOA 💬 D02561 💬 Moclobemide 1件:  6  💬
60 Serotonergic synapse 💬
2件: MAOA, MAOB 💬 D02579 💬 Iproniazid 1件:  6  💬
61 Serotonergic synapse 💬
2件: MAOA, MAOB 💬 D08349 💬 Phenelzine 1件:  6  💬
62 Serotonergic synapse 💬
3件: MAOA, MAOB, SLC6A4 💬 D05458 💬 Phentermine 1件: 97 💬
63 Serotonergic synapse 💬
1件: MAOB 💬 D08469 💬 Rasagiline 6件:  2 ,  5 ,  6 , 17, 58, 66 💬
64 Serotonergic synapse 💬
1件: MAOB 💬 D10829 💬 Rasagiline 6件:  2 ,  5 ,  6 , 17, 58, 66 💬
65 Serotonergic synapse 💬
1件: MAOB 💬 D10158 💬 Safinamide 2件:  6 , 17 💬
66 Serotonergic synapse 💬
1件: MAOB 💬 D03731 💬 Selegiline 1件:  6  💬
67 Serotonergic synapse 💬
1件: MAP2K1 💬 D10604 💬 Binimetinib 1件: 34 💬
68 Serotonergic synapse 💬
1件: MAP2K1 💬 D10405 💬 Cobimetinib 1件: 280 💬
69 Serotonergic synapse 💬
1件: MAP2K1 💬 D11675 💬 Mirdametinib 1件: 34 💬
70 Serotonergic synapse 💬
1件: MAP2K1 💬 D09666 💬 Selumetinib 1件: 34 💬
71 Serotonergic synapse 💬
1件: MAP2K1 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
72 Serotonergic synapse 💬
1件: PRKCB 💬 D11935 💬 Enzastaurin 1件: 168 💬
73 Serotonergic synapse 💬
2件: PTGS1, PTGS2 💬 D01545 💬 Aceclofenac 1件: 46 💬
74 Serotonergic synapse 💬
2件: PTGS1, PTGS2 💬 D00217 💬 Acetaminophen 15件:  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬
75 Serotonergic synapse 💬
2件: PTGS1, PTGS2 💬 D00109 💬 Acetylsalicylic acid 14件: 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬
76 Serotonergic synapse 💬
2件: PTGS1, PTGS2 💬 D07816 💬 Diclofenac 5件: 13, 34, 46, 78, 271 💬
77 Serotonergic synapse 💬
2件: PTGS1, PTGS2 💬 D00330 💬 Flurbiprofen 3件: 13, 21, 46 💬
78 Serotonergic synapse 💬
2件: PTGS1, PTGS2 💬 D00126 💬 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299 💬
79 Serotonergic synapse 💬
2件: PTGS1, PTGS2 💬 D00141 💬 Indomethacin 3件: 225, 271, 298 💬
80 Serotonergic synapse 💬
2件: PTGS1, PTGS2 💬 D00132 💬 Ketoprofen 1件: 46 💬
81 Serotonergic synapse 💬
2件: PTGS1, PTGS2 💬 D08104 💬 Ketorolac 2件: 70, 226 💬
82 Serotonergic synapse 💬
2件: PTGS1, PTGS2 💬 D08149 💬 Loxoprofen 2件: 46, 271 💬
83 Serotonergic synapse 💬
2件: PTGS1, PTGS2 💬 D00118 💬 Naproxen 4件: 13, 46, 107, 271 💬
84 Serotonergic synapse 💬
2件: PTGS1, PTGS2 💬 D00428 💬 Salsalate 1件:  5  💬
85 Serotonergic synapse 💬
2件: PTGS1, PTGS2 💬 D00120 💬 Sulindac 1件: 206 💬
86 Serotonergic synapse 💬
2件: PTGS1, PTGS2 💬 D01183 💬 Tolfenamic acid 1件:  5  💬
87 Serotonergic synapse 💬
1件: PTGS2 💬 D00567 💬 Celecoxib 10件:  2 ,  3 , 34, 46, 70, 89, 107, 161, 171, 271 💬
88 Serotonergic synapse 💬
1件: PTGS2 💬 D00130 💬 Diflunisal 1件: 28 💬
89 Serotonergic synapse 💬
1件: PTGS2 💬 D00315 💬 Etodolac 1件: 46 💬
90 Serotonergic synapse 💬
1件: PTGS2 💬 D03710 💬 Etoricoxib 2件: 46, 271 💬
91 Serotonergic synapse 💬
1件: PTGS2 💬 D03714 💬 Lumiracoxib 1件: 46 💬
92 Serotonergic synapse 💬
1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
93 Serotonergic synapse 💬
1件: PTGS2 💬 D01049 💬 Nimesulide 1件: 46 💬
94 Serotonergic synapse 💬
1件: PTGS2 💬 D03716 💬 Parecoxib 2件: 46, 271 💬
95 Serotonergic synapse 💬
1件: PTGS2 💬 D00568 💬 Rofecoxib 1件: 46 💬
96 Serotonergic synapse 💬
1件: PTGS2 💬 D02709 💬 Valdecoxib 1件: 46 💬
97 Serotonergic synapse 💬
1件: SLC18A2 💬 D10701 💬 Deutetrabenazine 1件:  8  💬
98 Serotonergic synapse 💬
1件: SLC18A2 💬 D08575 💬 Tetrabenazine 1件:  8  💬
99 Serotonergic synapse 💬
1件: SLC18A2 💬 D10675 💬 Valbenazine 1件:  8  💬
100 Serotonergic synapse 💬
1件: SLC6A4 💬 D07448 💬 Amitriptyline 4件: 78, 97, 226, 299 💬
101 Serotonergic synapse 💬
1件: SLC6A4 💬 D00228 💬 Amoxapine 1件: 46 💬
102 Serotonergic synapse 💬
1件: SLC6A4 💬 D11688 💬 Ampreloxetine 2件:  6 , 17 💬
103 Serotonergic synapse 💬
1件: SLC6A4 💬 D07704 💬 Citalopram 7件:  6 ,  8 , 13, 18, 46, 98, 127 💬
104 Serotonergic synapse 💬
1件: SLC6A4 💬 D07791 💬 Desipramine 2件: 120, 156 💬
105 Serotonergic synapse 💬
1件: SLC6A4 💬 D07875 💬 Doxepin 1件:  6  💬
106 Serotonergic synapse 💬
1件: SLC6A4 💬 D07880 💬 Duloxetine 2件:  6 , 13 💬
107 Serotonergic synapse 💬
1件: SLC6A4 💬 D07913 💬 Escitalopram 4件:  2 ,  6 , 13, 46 💬
108 Serotonergic synapse 💬
1件: SLC6A4 💬 D00326 💬 Fluoxetine 6件: 13, 17, 78, 86, 179, 206 💬
109 Serotonergic synapse 💬
1件: SLC6A4 💬 D08222 💬 Milnacipran 2件: 46, 49 💬
110 Serotonergic synapse 💬
1件: SLC6A4 💬 D08288 💬 Nortriptyline 2件:  6 , 226 💬
111 Serotonergic synapse 💬
1件: SLC6A4 💬 D02362 💬 Paroxetine 4件:  6 , 13, 46, 85 💬
112 Serotonergic synapse 💬
1件: SLC6A4 💬 D02360 💬 Sertraline 2件:  6 , 206 💬
113 Serotonergic synapse 💬
1件: SLC6A4 💬 D08670 💬 Venlafaxine 3件:  6 , 13, 46 💬
114 Serotonergic synapse 💬
2件: TPH1, TPH2 💬 D09973 💬 Telotristat 1件: 97 💬