Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	CETP	[1] Cholesterol metabolism	D08855	Anacetrapib	[1] 79
2	PCSK9	[1] Cholesterol metabolism	D10335	Alirocumab	[1] 79
3	PCSK9	[1] Cholesterol metabolism	D10557	Evolocumab	[2] 79, 222
4	PCSK9	[1] Cholesterol metabolism	D11931	Inclisiran	[1] 79
5	ANGPTL3	[1] Cholesterol metabolism	D11753	Evinacumab	[1] 79
6	NR3C1	[1] Neuroactive ligand-receptor interaction	D00473	Prednisone	[22] 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307 ...
7	NPC1L1	[1] Fat digestion and absorption	D01966	Ezetimibe	[3] 79, 93, 260
8	HMGCR	[4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion	D00359	Lovastatin	[11] 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310
9	HMGCR	[4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion	D00434	Simvastatin	[21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
10	HMGCR	[4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion	D07474	Atorvastatin	[19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299

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