Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 SIGMAR1 [2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases D03742 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
2 SIGMAR1 [2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases D07945 Fenfluramine [4] 140, 144, 145, 149
3 SIGMAR1 [2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases D11383 Blarcamesine [1] 156
4 SLC22A12 - D01056 Benzbromarone [1] 86
5 S1PR1 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10001 Fingolimod [3] 13, 14, 156
6 S1PR1 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10905 Amiselimod [1] 97
7 S1PR1 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10930 Etrasimod [3] 96, 97, 98
8 S1PR1 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10968 Ozanimod [3] 13, 96, 97
9 S1PR1 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D11215 Ponesimod [1] 13
10 S1PR1 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D11283 Cenerimod [1] 49
11 S1PR1 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D11460 Siponimod [2] 13, 50
12 S1PR3 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10905 Amiselimod [1] 97
13 S1PR3 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10930 Etrasimod [3] 96, 97, 98
14 S1PR3 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10968 Ozanimod [3] 13, 96, 97
15 SV2C [1] ECM-receptor interaction D11842 Padsevonil [1] 149
16 SIGLEC8 - D11906 Lirentelimab [1] 98
17 SERPIND1 [1] Complement and coagulation cascades D08547 Sulodexide [2] 51, 271
18 SMAD7 [2] TGF-beta signaling pathway, Hippo signaling pathway D10956 Mongersen [2] 96, 97
19 SERPINC1 [1] Complement and coagulation cascades D07510 Heparin [11] 47, 60, 70, 84, 107, 224, 226, 280, 299, 316, 317
20 SERPINC1 [1] Complement and coagulation cascades D07510 Enoxaparin [1] 46
21 SERPINC1 [1] Complement and coagulation cascades D07510 Parnaparin [1] 97
22 SERPINC1 [1] Complement and coagulation cascades D08547 Sulodexide [2] 51, 271
23 SOST [2] Wnt signaling pathway, Parathyroid hormone synthesis, secretion and action D10156 Romosozumab [1] 274
24 S1PR5 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10905 Amiselimod [1] 97
25 S1PR5 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10930 Etrasimod [3] 96, 97, 98
26 S1PR5 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10968 Ozanimod [3] 13, 96, 97
27 S1PR5 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D11460 Siponimod [2] 13, 50
28 SLAMF7 - D09337 Elotuzumab [1] 28
29 SORT1 [3] Lysosome, Neurotrophin signaling pathway, Cholesterol metabolism D12427 Latozinemab [2] 2, 127
30 SCN1A [1] Dopaminergic synapse D00252 Carbamazepine [3] 6, 13, 231
31 SCN1A [1] Dopaminergic synapse D00354 Lamotrigine [5] 13, 34, 38, 114, 144
32 SCN1A [1] Dopaminergic synapse D00358 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256
33 SCN1A [1] Dopaminergic synapse D00512 Phenytoin [1] 13
34 SCN1A [1] Dopaminergic synapse D00533 Oxcarbazepine [1] 13
35 SCN1A [1] Dopaminergic synapse D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
36 SCN1A [1] Dopaminergic synapse D00538 Zonisamide [1] 6
37 SCN1A [1] Dopaminergic synapse D02910 Amiodarone [2] 28, 127
38 SCN1A [1] Dopaminergic synapse D03492 Cibenzoline [1] 58
39 SCN1A [1] Dopaminergic synapse D05775 Rufinamide [1] 144
40 SCN1A [1] Dopaminergic synapse D07552 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298
41 SCN1A [1] Dopaminergic synapse D07962 Flecainide [1] 6
42 SCN1A [1] Dopaminergic synapse D08116 Levobupivacaine [1] 46
43 SCN1A [1] Dopaminergic synapse D08127 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256
44 SCN1A [1] Dopaminergic synapse D08215 Mexiletine [5] 1, 2, 10, 113, 114
45 SCN1A [1] Dopaminergic synapse D08319 Oxybuprocaine [1] 6
46 SCN1A [1] Dopaminergic synapse D08458 Quinidine [3] 2, 8, 13
47 SCN1A [1] Dopaminergic synapse D08490 Ropivacaine [4] 22, 36, 46, 70
48 SCN1A [1] Dopaminergic synapse D11155 Eleclazine [1] 58
49 SCN2A [1] Taste transduction D00252 Carbamazepine [3] 6, 13, 231
50 SCN2A [1] Taste transduction D00354 Lamotrigine [5] 13, 34, 38, 114, 144
51 SCN2A [1] Taste transduction D00358 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256
52 SCN2A [1] Taste transduction D00512 Phenytoin [1] 13
53 SCN2A [1] Taste transduction D00533 Oxcarbazepine [1] 13
54 SCN2A [1] Taste transduction D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
55 SCN2A [1] Taste transduction D00538 Zonisamide [1] 6
56 SCN2A [1] Taste transduction D02910 Amiodarone [2] 28, 127
57 SCN2A [1] Taste transduction D03492 Cibenzoline [1] 58
58 SCN2A [1] Taste transduction D05775 Rufinamide [1] 144
59 SCN2A [1] Taste transduction D07552 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298
60 SCN2A [1] Taste transduction D07962 Flecainide [1] 6
61 SCN2A [1] Taste transduction D08116 Levobupivacaine [1] 46
62 SCN2A [1] Taste transduction D08127 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256
63 SCN2A [1] Taste transduction D08215 Mexiletine [5] 1, 2, 10, 113, 114
64 SCN2A [1] Taste transduction D08319 Oxybuprocaine [1] 6
65 SCN2A [1] Taste transduction D08458 Quinidine [3] 2, 8, 13
66 SCN2A [1] Taste transduction D08490 Ropivacaine [4] 22, 36, 46, 70
67 SCN2A [1] Taste transduction D11155 Eleclazine [1] 58
68 SCN3A [1] Taste transduction D00252 Carbamazepine [3] 6, 13, 231
69 SCN3A [1] Taste transduction D00354 Lamotrigine [5] 13, 34, 38, 114, 144
70 SCN3A [1] Taste transduction D00358 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256
71 SCN3A [1] Taste transduction D00512 Phenytoin [1] 13
72 SCN3A [1] Taste transduction D00533 Oxcarbazepine [1] 13
73 SCN3A [1] Taste transduction D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
74 SCN3A [1] Taste transduction D00538 Zonisamide [1] 6
75 SCN3A [1] Taste transduction D02910 Amiodarone [2] 28, 127
76 SCN3A [1] Taste transduction D03492 Cibenzoline [1] 58
77 SCN3A [1] Taste transduction D05775 Rufinamide [1] 144
78 SCN3A [1] Taste transduction D07299 Lacosamide [4] 2, 46, 149, 298
79 SCN3A [1] Taste transduction D07552 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298
80 SCN3A [1] Taste transduction D07962 Flecainide [1] 6
81 SCN3A [1] Taste transduction D08116 Levobupivacaine [1] 46
82 SCN3A [1] Taste transduction D08127 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256
83 SCN3A [1] Taste transduction D08215 Mexiletine [5] 1, 2, 10, 113, 114
84 SCN3A [1] Taste transduction D08319 Oxybuprocaine [1] 6
85 SCN3A [1] Taste transduction D08458 Quinidine [3] 2, 8, 13
86 SCN3A [1] Taste transduction D08490 Ropivacaine [4] 22, 36, 46, 70
87 SCN3A [1] Taste transduction D11155 Eleclazine [1] 58
88 SCN5A [1] Adrenergic signaling in cardiomyocytes D00252 Carbamazepine [3] 6, 13, 231
89 SCN5A [1] Adrenergic signaling in cardiomyocytes D00354 Lamotrigine [5] 13, 34, 38, 114, 144
90 SCN5A [1] Adrenergic signaling in cardiomyocytes D00358 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256
91 SCN5A [1] Adrenergic signaling in cardiomyocytes D00512 Phenytoin [1] 13
92 SCN5A [1] Adrenergic signaling in cardiomyocytes D00533 Oxcarbazepine [1] 13
93 SCN5A [1] Adrenergic signaling in cardiomyocytes D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
94 SCN5A [1] Adrenergic signaling in cardiomyocytes D00538 Zonisamide [1] 6
95 SCN5A [1] Adrenergic signaling in cardiomyocytes D02910 Amiodarone [2] 28, 127
96 SCN5A [1] Adrenergic signaling in cardiomyocytes D03492 Cibenzoline [1] 58
97 SCN5A [1] Adrenergic signaling in cardiomyocytes D05775 Rufinamide [1] 144
98 SCN5A [1] Adrenergic signaling in cardiomyocytes D07552 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298
99 SCN5A [1] Adrenergic signaling in cardiomyocytes D07962 Flecainide [1] 6
100 SCN5A [1] Adrenergic signaling in cardiomyocytes D08116 Levobupivacaine [1] 46
101 SCN5A [1] Adrenergic signaling in cardiomyocytes D08127 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256
102 SCN5A [1] Adrenergic signaling in cardiomyocytes D08215 Mexiletine [5] 1, 2, 10, 113, 114
103 SCN5A [1] Adrenergic signaling in cardiomyocytes D08319 Oxybuprocaine [1] 6
104 SCN5A [1] Adrenergic signaling in cardiomyocytes D08458 Quinidine [3] 2, 8, 13
105 SCN5A [1] Adrenergic signaling in cardiomyocytes D08490 Ropivacaine [4] 22, 36, 46, 70
106 SCN5A [1] Adrenergic signaling in cardiomyocytes D11155 Eleclazine [1] 58
107 SCN9A [1] Taste transduction D00252 Carbamazepine [3] 6, 13, 231
108 SCN9A [1] Taste transduction D00354 Lamotrigine [5] 13, 34, 38, 114, 144
109 SCN9A [1] Taste transduction D00358 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256
110 SCN9A [1] Taste transduction D00512 Phenytoin [1] 13
111 SCN9A [1] Taste transduction D00533 Oxcarbazepine [1] 13
112 SCN9A [1] Taste transduction D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
113 SCN9A [1] Taste transduction D00538 Zonisamide [1] 6
114 SCN9A [1] Taste transduction D02910 Amiodarone [2] 28, 127
115 SCN9A [1] Taste transduction D03492 Cibenzoline [1] 58
116 SCN9A [1] Taste transduction D05775 Rufinamide [1] 144
117 SCN9A [1] Taste transduction D07299 Lacosamide [4] 2, 46, 149, 298
118 SCN9A [1] Taste transduction D07552 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298
119 SCN9A [1] Taste transduction D07962 Flecainide [1] 6
120 SCN9A [1] Taste transduction D08116 Levobupivacaine [1] 46
121 SCN9A [1] Taste transduction D08127 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256
122 SCN9A [1] Taste transduction D08215 Mexiletine [5] 1, 2, 10, 113, 114
123 SCN9A [1] Taste transduction D08319 Oxybuprocaine [1] 6
124 SCN9A [1] Taste transduction D08458 Quinidine [3] 2, 8, 13
125 SCN9A [1] Taste transduction D08490 Ropivacaine [4] 22, 36, 46, 70
126 SCN9A [1] Taste transduction D11155 Eleclazine [1] 58
127 SCNN1A [2] Taste transduction, Aldosterone-regulated sodium reabsorption D07447 Amiloride [4] 13, 67, 225, 299
128 SCNN1B [2] Taste transduction, Aldosterone-regulated sodium reabsorption D07447 Amiloride [4] 13, 67, 225, 299
129 SCNN1G [2] Taste transduction, Aldosterone-regulated sodium reabsorption D07447 Amiloride [4] 13, 67, 225, 299
130 SLC5A2 - D08897 Dapagliflozin [7] 19, 49, 66, 67, 86, 88, 222
131 SLC5A2 - D10459 Empagliflozin [6] 58, 65, 67, 72, 97, 257
132 SLC6A1 [2] Synaptic vesicle cycle, GABAergic synapse D00332 Gabapentin [5] 6, 13, 19, 70, 298
133 SLC6A2 [1] Synaptic vesicle cycle D00228 Amoxapine [1] 46
134 SLC6A2 [1] Synaptic vesicle cycle D04999 Methylphenidate [7] 6, 13, 34, 84, 113, 179, 206
135 SLC6A2 [1] Synaptic vesicle cycle D05458 Phentermine [1] 97
136 SLC6A2 [1] Synaptic vesicle cycle D07448 Amitriptyline [4] 78, 97, 226, 299
137 SLC6A2 [1] Synaptic vesicle cycle D07473 Atomoxetine [4] 6, 8, 13, 17
138 SLC6A2 [1] Synaptic vesicle cycle D07591 Bupropion [5] 8, 18, 21, 96, 171
139 SLC6A2 [1] Synaptic vesicle cycle D07791 Desipramine [2] 120, 156
140 SLC6A2 [1] Synaptic vesicle cycle D07875 Doxepin [1] 6
141 SLC6A2 [1] Synaptic vesicle cycle D07880 Duloxetine [2] 6, 13
142 SLC6A2 [1] Synaptic vesicle cycle D08130 Lisdexamfetamine [1] 13
143 SLC6A2 [1] Synaptic vesicle cycle D08222 Milnacipran [2] 46, 49
144 SLC6A2 [1] Synaptic vesicle cycle D08288 Nortriptyline [2] 6, 226
145 SLC6A2 [1] Synaptic vesicle cycle D08670 Venlafaxine [3] 6, 13, 46
146 SLC6A2 [1] Synaptic vesicle cycle D11688 Ampreloxetine [2] 6, 17
147 SLC6A3 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism D03215 Armodafinil [3] 6, 13, 84
148 SLC6A3 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism D04999 Methylphenidate [7] 6, 13, 34, 84, 113, 179, 206
149 SLC6A3 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism D05458 Phentermine [1] 97
150 SLC6A3 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism D07591 Bupropion [5] 8, 18, 21, 96, 171
151 SLC6A3 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism D08130 Lisdexamfetamine [1] 13
152 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D00228 Amoxapine [1] 46
153 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D00326 Fluoxetine [6] 13, 17, 78, 86, 179, 206
154 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D02360 Sertraline [2] 6, 206
155 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D02362 Paroxetine [4] 6, 13, 46, 85
156 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D05458 Phentermine [1] 97
157 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D07448 Amitriptyline [4] 78, 97, 226, 299
158 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D07704 Citalopram [7] 6, 8, 13, 18, 46, 98, 127
159 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D07791 Desipramine [2] 120, 156
160 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D07875 Doxepin [1] 6
161 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D07880 Duloxetine [2] 6, 13
162 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D07913 Escitalopram [4] 2, 6, 13, 46
163 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D07945 Fenfluramine [4] 140, 144, 145, 149
164 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D08222 Milnacipran [2] 46, 49
165 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D08288 Nortriptyline [2] 6, 226
166 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D08626 Trazodone [1] 2
167 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D08670 Venlafaxine [3] 6, 13, 46
168 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D10184 Vortioxetine [1] 6
169 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D11688 Ampreloxetine [2] 6, 17
170 SLC10A1 [2] Bile secretion, Hepatitis B D10951 Maralixibat [3] 296, 297, 338
171 SLC10A2 [1] Bile secretion D10796 Elobixibat [1] 6
172 SLC10A2 [1] Bile secretion D10951 Maralixibat [3] 296, 297, 338
173 SLC10A2 [1] Bile secretion D11716 Odevixibat [3] 296, 297, 338
174 SLC12A2 [3] Salivary secretion, Pancreatic secretion, Vibrio cholerae infection D00247 Bumetanide [2] 6, 158
175 SLC12A2 [3] Salivary secretion, Pancreatic secretion, Vibrio cholerae infection D00331 Furosemide [2] 6, 86
176 SLC12A3 - D00340 Hydrochlorothiazide [4] 13, 67, 225, 235
177 SLC12A3 - D00345 Indapamide [1] 13
178 SLC12A3 - D00519 Chlorothiazide [1] 225
179 SLC12A3 - D00650 Bendroflumethiazide [1] 67
180 SLC18A2 [7] Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism D08575 Tetrabenazine [1] 8
181 SLC18A2 [7] Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism D10675 Valbenazine [1] 8
182 SLC18A2 [7] Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism D10701 Deutetrabenazine [1] 8
183 SMN1 - D11559 Onasemnogene abeparvovec [1] 3
184 SMN2 - D10881 Nusinersen [1] 3
185 SMN2 [1] Nucleocytoplasmic transport D11406 Risdiplam [1] 3
186 SMN2 - D12272 Branaplam [2] 3, 8
187 SMO [5] Hedgehog signaling pathway, Axon guidance, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma D09992 Vismodegib [1] 85
188 SMO [5] Hedgehog signaling pathway, Axon guidance, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma D10671 Taladegib [1] 85
189 SMPD1 [5] Sphingolipid metabolism, Metabolic pathways, Sphingolipid signaling pathway, Lysosome, Necroptosis D10820 Olipudase alfa [1] 19
190 SNAP25 [2] Synaptic vesicle cycle, Insulin secretion D00783 Botulinum toxin type A [14] 2, 5, 6, 7, 13, 15, 17, 36, 47, 51, 70, 113, 149, 226
191 SNAP25 [2] Synaptic vesicle cycle, Insulin secretion D02735 Botulinum toxin type B [4] 2, 6, 13, 51
192 SNCA [3] Alzheimer disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases D11420 Prasinezumab [1] 6
193 SOD1 [8] Peroxisome, Longevity regulating pathway - multiple species, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - reactive oxygen species D11811 Tofersen [1] 2
194 SRC [42] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Mitophagy - animal, Endocytosis, Axon guidance, VEGF signaling pathway, Focal adhesion, Adherens junction, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Bacterial invasion of epithelial cells, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Bladder cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D03252 Bosutinib [2] 2, 67
195 SRC [42] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Mitophagy - animal, Endocytosis, Axon guidance, VEGF signaling pathway, Focal adhesion, Adherens junction, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Bacterial invasion of epithelial cells, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Bladder cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D03658 Dasatinib [2] 51, 85
196 SRC [42] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Mitophagy - animal, Endocytosis, Axon guidance, VEGF signaling pathway, Focal adhesion, Adherens junction, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Bacterial invasion of epithelial cells, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Bladder cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D06414 Dasatinib [2] 51, 85
197 SRC [42] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Mitophagy - animal, Endocytosis, Axon guidance, VEGF signaling pathway, Focal adhesion, Adherens junction, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Bacterial invasion of epithelial cells, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Bladder cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D09664 Saracatinib [3] 6, 89, 272
198 SRD5A1 [2] Steroid hormone biosynthesis, Metabolic pathways D03820 Dutasteride [2] 1, 2
199 SRD5A2 [3] Steroid hormone biosynthesis, Metabolic pathways, Prostate cancer D00321 Finasteride [1] 6
200 SRD5A2 [3] Steroid hormone biosynthesis, Metabolic pathways, Prostate cancer D03820 Dutasteride [2] 1, 2
201 SSTR1 [3] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D07431 Somatostatin [2] 67, 78
202 SSTR1 [3] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D10147 Pasireotide [3] 67, 74, 75
203 SSTR2 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D00442 Octreotide [7] 67, 75, 84, 85, 89, 193, 227
204 SSTR2 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D07431 Somatostatin [2] 67, 78
205 SSTR2 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D10147 Pasireotide [3] 67, 74, 75
206 SSTR3 [2] Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D07431 Somatostatin [2] 67, 78
207 SSTR3 [2] Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D10147 Pasireotide [3] 67, 74, 75
208 SSTR4 [1] Neuroactive ligand-receptor interaction D07431 Somatostatin [2] 67, 78
209 SSTR5 [3] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D07431 Somatostatin [2] 67, 78
210 SSTR5 [3] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D10147 Pasireotide [3] 67, 74, 75
211 SYK [17] NF-kappa B signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Osteoclast differentiation, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Viral carcinogenesis D09347 Fostamatinib [4] 46, 49, 61, 66
212 S1PR4 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10905 Amiselimod [1] 97
213 S1PR4 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10930 Etrasimod [3] 96, 97, 98
214 S1PR4 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10968 Ozanimod [3] 13, 96, 97
215 S1PR2 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10905 Amiselimod [1] 97
216 S1PR2 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10930 Etrasimod [3] 96, 97, 98
217 S1PR2 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10968 Ozanimod [3] 13, 96, 97
218 SV2B [1] ECM-receptor interaction D11842 Padsevonil [1] 149
219 SV2A [1] ECM-receptor interaction D00709 Levetiracetam [5] 2, 4, 6, 13, 307
220 SV2A [1] ECM-receptor interaction D08879 Brivaracetam [2] 149, 309
221 SV2A [1] ECM-receptor interaction D11842 Padsevonil [1] 149