Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	SIGMAR1	[2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases	D03742	Dextromethorphan	[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
2	SIGMAR1	[2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases	D07945	Fenfluramine	[4] 140, 144, 145, 149
3	SIGMAR1	[2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases	D11383	Blarcamesine	[1] 156
4	SLC22A12	-	D01056	Benzbromarone	[1] 86
5	S1PR1	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	D10001	Fingolimod	[3] 13, 14, 156
6	S1PR1	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	D10905	Amiselimod	[1] 97
7	S1PR1	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	D10930	Etrasimod	[3] 96, 97, 98
8	S1PR1	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	D10968	Ozanimod	[3] 13, 96, 97
9	S1PR1	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	D11215	Ponesimod	[1] 13
10	S1PR1	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	D11283	Cenerimod	[1] 49

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