Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	ODC1	[3] Arginine and proline metabolism, Glutathione metabolism, Metabolic pathways	D07883	Eflornithine	[1] 65
2	OPRD1	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interact ...	D05111	Nalmefene	[1] 6
3	OPRD1	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interact ...	D05113	Naltrexone	[13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
4	OPRD1	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interact ...	D05312	Oxycodone	[5] 6, 13, 70, 226, 298
5	OPRD1	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interact ...	D08144	Loperamide	[2] 13, 97
6	OPRD1	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interact ...	D08246	Nalbuphine	[1] 85
7	OPRD1	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interact ...	D08249	Naloxone	[2] 6, 226
8	OPRK1	[1] Neuroactive ligand-receptor interaction	D00838	Dezocine	[1] 46
9	OPRK1	[1] Neuroactive ligand-receptor interaction	D05111	Nalmefene	[1] 6
10	OPRK1	[1] Neuroactive ligand-receptor interaction	D05113	Naltrexone	[13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226

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