Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	DHFR	[4] One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors	D00142	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
2	DHODH	[3] Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors	D00749	Leflunomide	[12] 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300
3	DHODH	[3] Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors	D10172	Teriflunomide	[3] 13, 25, 26
4	NQO1	[7] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Biosynthesis of cofacto ...	D08682	Warfarin	[11] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91
5	DHFR2	[4] One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors	D00142	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
6	ALAS1	[4] Glycine, serine and threonine metabolism, Porphyrin metabolism, Metabolic pathways, Biosynthesis ...	D10003	Hemin	[1] 254
7	ALAS1	[4] Glycine, serine and threonine metabolism, Porphyrin metabolism, Metabolic pathways, Biosynthesis ...	D11702	Givosiran	[1] 254
8	ALAS2	[4] Glycine, serine and threonine metabolism, Porphyrin metabolism, Metabolic pathways, Biosynthesis ...	D10003	Hemin	[1] 254
9	ALPL	[4] Thiamine metabolism, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors	D10595	Asfotase alfa	[1] 172
10	GUSB	[7] Pentose and glucuronate interconversions, Glycosaminoglycan degradation, Porphyrin metabolism, D ...	D11004	Vestronidase alfa	[1] 19

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