Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 GAD1 [1] Type I diabetes mellitus D00399 Valproic acid [14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256
2 GAD2 [1] Type I diabetes mellitus D00399 Valproic acid [14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256
3 IFNG [1] Type I diabetes mellitus D04242 Fontolizumab [1] 46
4 IFNG [1] Type I diabetes mellitus D11120 Emapalumab [3] 49, 65, 107
5 IL1A [1] Type I diabetes mellitus D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
6 IL1A [1] Type I diabetes mellitus D06635 Rilonacept [4] 51, 106, 107, 266
7 IL1A [1] Type I diabetes mellitus D11253 Bermekimab [1] 51
8 IL1B [2] Type I diabetes mellitus, Yersinia infection D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
9 IL1B [2] Type I diabetes mellitus, Yersinia infection D06635 Rilonacept [4] 51, 106, 107, 266
10 IL1B [2] Type I diabetes mellitus, Yersinia infection D09315 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269
11 IL1B [2] Type I diabetes mellitus, Yersinia infection D09911 Gevokizumab [4] 41, 50, 56, 269
12 IL12A [1] Type I diabetes mellitus D09214 Ustekinumab [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
13 IL12B [1] Type I diabetes mellitus D09214 Ustekinumab [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
14 LTA [2] Viral protein interaction with cytokine and cytokine receptor, Type I diabetes mellitus D00742 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
15 LTA [2] Viral protein interaction with cytokine and cytokine receptor, Type I diabetes mellitus D10187 Pateclizumab [1] 46
16 TNF [4] Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection D00742 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
17 TNF [4] Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection D00754 Thalidomide [20] 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
18 TNF [4] Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
19 TNF [4] Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection D02597 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271
20 TNF [4] Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection D02598 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
21 TNF [4] Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection D03441 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271
22 TNF [4] Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection D04358 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271
23 TNF [4] Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection D04687 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331
24 TNF [4] Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection D05393 Pegsunercept [1] 46
25 TNF [4] Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection D08976 Pomalidomide [5] 28, 51, 85, 227, 331
26 TNF [4] Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection D09944 Ozoralizumab [1] 46
27 CD80 [3] Virion - Adenovirus, Type I diabetes mellitus, Viral myocarditis D03203 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
28 CD80 [3] Virion - Adenovirus, Type I diabetes mellitus, Viral myocarditis D03222 Belatacept [1] 46
29 CD86 [3] Virion - Adenovirus, Type I diabetes mellitus, Viral myocarditis D03203 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
30 CD86 [3] Virion - Adenovirus, Type I diabetes mellitus, Viral myocarditis D03222 Belatacept [1] 46