Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	S1PR1	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	D10001	Fingolimod	[3] 13, 14, 156
2	S1PR1	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	D10905	Amiselimod	[1] 97
3	S1PR1	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	D10930	Etrasimod	[3] 96, 97, 98
4	S1PR1	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	D10968	Ozanimod	[3] 13, 96, 97
5	S1PR1	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	D11215	Ponesimod	[1] 13
6	S1PR1	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	D11283	Cenerimod	[1] 49
7	S1PR1	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	D11460	Siponimod	[2] 13, 50

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