Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	OPRD1	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interact ...	D05111	Nalmefene	[1] 6
2	OPRD1	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interact ...	D05113	Naltrexone	[13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
3	OPRD1	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interact ...	D05312	Oxycodone	[5] 6, 13, 70, 226, 298
4	OPRD1	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interact ...	D08144	Loperamide	[2] 13, 97
5	OPRD1	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interact ...	D08246	Nalbuphine	[1] 85
6	OPRD1	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interact ...	D08249	Naloxone	[2] 6, 226

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