Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	OPRK1	[1] Neuroactive ligand-receptor interaction	D00838	Dezocine	[1] 46
2	OPRK1	[1] Neuroactive ligand-receptor interaction	D05111	Nalmefene	[1] 6
3	OPRK1	[1] Neuroactive ligand-receptor interaction	D05113	Naltrexone	[13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
4	OPRK1	[1] Neuroactive ligand-receptor interaction	D05312	Oxycodone	[5] 6, 13, 70, 226, 298
5	OPRK1	[1] Neuroactive ligand-receptor interaction	D07132	Buprenorphine	[2] 46, 70
6	OPRK1	[1] Neuroactive ligand-receptor interaction	D08144	Loperamide	[2] 13, 97
7	OPRK1	[1] Neuroactive ligand-receptor interaction	D08246	Nalbuphine	[1] 85
8	OPRK1	[1] Neuroactive ligand-receptor interaction	D08249	Naloxone	[2] 6, 226
9	OPRK1	[1] Neuroactive ligand-receptor interaction	D08639	Trimebutine	[1] 51

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