Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Alanine, aspartate and glutamate metabolism 💬	[1] CPS1 💬	D07130 💬	Carglumic acid	[3] 245, 246, 251 💬
2	Aldosterone synthesis and secretion 💬	[1] PDE2A 💬	D07546 💬	Bucladesine	[1] 246 💬
3	Apelin signaling pathway 💬	[1] PDE3B 💬	D07546 💬	Bucladesine	[1] 246 💬
4	Arginine biosynthesis 💬	[1] CPS1 💬	D07130 💬	Carglumic acid	[3] 245, 246, 251 💬
5	Biosynthesis of amino acids 💬	[1] CPS1 💬	D07130 💬	Carglumic acid	[3] 245, 246, 251 💬
6	Calcium signaling pathway 💬	[3] PDE1A, PDE1B, PDE1C 💬	D07546 💬	Bucladesine	[1] 246 💬
7	cAMP signaling pathway 💬	[7] PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬	D07546 💬	Bucladesine	[1] 246 💬
8	Carbon metabolism 💬	[1] CPS1 💬	D07130 💬	Carglumic acid	[3] 245, 246, 251 💬
9	cGMP-PKG signaling pathway 💬	[3] PDE2A, PDE3A, PDE3B 💬	D07546 💬	Bucladesine	[1] 246 💬
10	Cortisol synthesis and secretion 💬	[2] PDE8A, PDE8B 💬	D07546 💬	Bucladesine	[1] 246 💬

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