Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank Disease ID
1 Alanine, aspartate and glutamate metabolism 💬
[1] CPS1 💬 D07130 💬 Carglumic acid [3] 245, 246, 251 💬
2 Aldosterone synthesis and secretion 💬
[1] PDE2A 💬 D07546 💬 Bucladesine [1] 246 💬
3 Apelin signaling pathway 💬
[1] PDE3B 💬 D07546 💬 Bucladesine [1] 246 💬
4 Arginine biosynthesis 💬
[1] CPS1 💬 D07130 💬 Carglumic acid [3] 245, 246, 251 💬
5 Biosynthesis of amino acids 💬
[1] CPS1 💬 D07130 💬 Carglumic acid [3] 245, 246, 251 💬
6 Calcium signaling pathway 💬
[3] PDE1A, PDE1B, PDE1C 💬 D07546 💬 Bucladesine [1] 246 💬
7 cAMP signaling pathway 💬
[7] PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 D07546 💬 Bucladesine [1] 246 💬
8 Carbon metabolism 💬
[1] CPS1 💬 D07130 💬 Carglumic acid [3] 245, 246, 251 💬
9 cGMP-PKG signaling pathway 💬
[3] PDE2A, PDE3A, PDE3B 💬 D07546 💬 Bucladesine [1] 246 💬
10 Cortisol synthesis and secretion 💬
[2] PDE8A, PDE8B 💬 D07546 💬 Bucladesine [1] 246 💬
11 Cushing syndrome 💬
[3] PDE11A, PDE8A, PDE8B 💬 D07546 💬 Bucladesine [1] 246 💬
12 Glucagon signaling pathway 💬
[1] PDE3B 💬 D07546 💬 Bucladesine [1] 246 💬
13 Insulin signaling pathway 💬
[1] PDE3B 💬 D07546 💬 Bucladesine [1] 246 💬
14 Metabolic pathways 💬
[1] CPS1 💬 D07130 💬 Carglumic acid [3] 245, 246, 251 💬
15 Metabolic pathways 💬
[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D07546 💬 Bucladesine [1] 246 💬
16 Morphine addiction 💬
[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D07546 💬 Bucladesine [1] 246 💬
17 Nitrogen metabolism 💬
[1] CPS1 💬 D07130 💬 Carglumic acid [3] 245, 246, 251 💬
18 Olfactory transduction 💬
[4] PDE1A, PDE1B, PDE1C, PDE2A 💬 D07546 💬 Bucladesine [1] 246 💬
19 Parathyroid hormone synthesis, secretion and action 💬
[4] PDE4A, PDE4B, PDE4C, PDE4D 💬 D07546 💬 Bucladesine [1] 246 💬
20 Progesterone-mediated oocyte maturation 💬
[1] PDE3B 💬 D07546 💬 Bucladesine [1] 246 💬
21 Purine metabolism 💬
[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D07546 💬 Bucladesine [1] 246 💬
22 Regulation of lipolysis in adipocytes 💬
[1] PDE3B 💬 D07546 💬 Bucladesine [1] 246 💬
23 Renin secretion 💬
[5] PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D07546 💬 Bucladesine [1] 246 💬
24 Taste transduction 💬
[3] PDE1A, PDE1B, PDE1C 💬 D07546 💬 Bucladesine [1] 246 💬