Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adherens junction 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
2 Alcoholism 💬
[2] DRD1, DRD2 💬 D07870 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
3 Alcoholism 💬
[1] DRD2 💬 D03165 💬 Bromocriptine [2]  6 , 74 💬
4 Alcoholism 💬
[1] DRD2 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
5 Alcoholism 💬
[1] DRD2 💬 D08489 💬 Ropinirole [4]  2 ,  6 , 74, 309 💬
6 Amphetamine addiction 💬
[1] DRD1 💬 D07870 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
7 Bladder cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
8 Breast cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
9 Breast cancer 💬
[2] ESR1, ESR2 💬 D07726 💬 Clomifene [1] 74 💬
10 Calcium signaling pathway 💬
[2] DRD1, DRD5 💬 D07870 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
11 Calcium signaling pathway 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
12 cAMP signaling pathway 💬
[3] DRD1, DRD2, DRD5 💬 D07870 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
13 cAMP signaling pathway 💬
[1] DRD2 💬 D03165 💬 Bromocriptine [2]  6 , 74 💬
14 cAMP signaling pathway 💬
[1] DRD2 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
15 cAMP signaling pathway 💬
[1] DRD2 💬 D08489 💬 Ropinirole [4]  2 ,  6 , 74, 309 💬
16 cAMP signaling pathway 💬
[3] SSTR1, SSTR2, SSTR5 💬 D10147 💬 Pasireotide [3] 67, 74, 75 💬
17 Central carbon metabolism in cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
18 Chemical carcinogenesis - reactive oxygen species 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
19 Chemical carcinogenesis - receptor activation 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
20 Chemical carcinogenesis - receptor activation 💬
[2] ESR1, ESR2 💬 D07726 💬 Clomifene [1] 74 💬
21 Choline metabolism in cancer 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
22 Cocaine addiction 💬
[2] DRD1, DRD2 💬 D07870 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
23 Cocaine addiction 💬
[1] DRD2 💬 D03165 💬 Bromocriptine [2]  6 , 74 💬
24 Cocaine addiction 💬
[1] DRD2 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
25 Cocaine addiction 💬
[1] DRD2 💬 D08489 💬 Ropinirole [4]  2 ,  6 , 74, 309 💬
26 Colorectal cancer 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
27 Coronavirus disease - COVID-19 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
28 Cushing syndrome 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
29 Cytokine-cytokine receptor interaction 💬
[1] PRL 💬 D03165 💬 Bromocriptine [2]  6 , 74 💬
30 Cytokine-cytokine receptor interaction 💬
[1] PRL 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
31 Dopaminergic synapse 💬
[5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 D07870 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
32 Dopaminergic synapse 💬
[1] DRD2 💬 D03165 💬 Bromocriptine [2]  6 , 74 💬
33 Dopaminergic synapse 💬
[1] DRD2 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
34 Dopaminergic synapse 💬
[3] DRD2, DRD3, DRD4 💬 D08489 💬 Ropinirole [4]  2 ,  6 , 74, 309 💬
35 EGFR tyrosine kinase inhibitor resistance 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
36 Endocrine and other factor-regulated calcium reabsorption 💬
[1] ESR1 💬 D07726 💬 Clomifene [1] 74 💬
37 Endocrine resistance 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
38 Endocrine resistance 💬
[2] ESR1, ESR2 💬 D07726 💬 Clomifene [1] 74 💬
39 Endocytosis 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
40 Endometrial cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
41 Epithelial cell signaling in Helicobacter pylori infection 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
42 ErbB signaling pathway 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
43 Estrogen signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
44 Estrogen signaling pathway 💬
[2] ESR1, ESR2 💬 D07726 💬 Clomifene [1] 74 💬
45 Focal adhesion 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
46 FoxO signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
47 Gap junction 💬
[2] DRD1, DRD2 💬 D07870 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
48 Gap junction 💬
[1] DRD2 💬 D03165 💬 Bromocriptine [2]  6 , 74 💬
49 Gap junction 💬
[1] DRD2 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
50 Gap junction 💬
[1] DRD2 💬 D08489 💬 Ropinirole [4]  2 ,  6 , 74, 309 💬
51 Gap junction 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
52 Gastric acid secretion 💬
[1] SSTR2 💬 D10147 💬 Pasireotide [3] 67, 74, 75 💬
53 Gastric cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
54 Glioma 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
55 GnRH secretion 💬
[1] ESR2 💬 D07726 💬 Clomifene [1] 74 💬
56 GnRH signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
57 Growth hormone synthesis, secretion and action 💬
[4] SSTR1, SSTR2, SSTR3, SSTR5 💬 D10147 💬 Pasireotide [3] 67, 74, 75 💬
58 Hepatitis C 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
59 Hepatocellular carcinoma 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
60 HIF-1 signaling pathway 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
61 Human cytomegalovirus infection 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
62 Human papillomavirus infection 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
63 JAK-STAT signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
64 JAK-STAT signaling pathway 💬
[1] PRL 💬 D03165 💬 Bromocriptine [2]  6 , 74 💬
65 JAK-STAT signaling pathway 💬
[1] PRL 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
66 MAPK signaling pathway 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
67 Melanoma 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
68 MicroRNAs in cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
69 Morphine addiction 💬
[1] DRD1 💬 D07870 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
70 Neuroactive ligand-receptor interaction 💬
[5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 D07870 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
71 Neuroactive ligand-receptor interaction 💬
[3] DRD2, DRD3, DRD4 💬 D08489 💬 Ropinirole [4]  2 ,  6 , 74, 309 💬
72 Neuroactive ligand-receptor interaction 💬
[2] DRD2, PRL 💬 D03165 💬 Bromocriptine [2]  6 , 74 💬
73 Neuroactive ligand-receptor interaction 💬
[2] DRD2, PRL 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
74 Neuroactive ligand-receptor interaction 💬
[4] SSTR1, SSTR2, SSTR3, SSTR5 💬 D10147 💬 Pasireotide [3] 67, 74, 75 💬
75 Non-small cell lung cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
76 Oxytocin signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
77 Pancreatic cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
78 Parathyroid hormone synthesis, secretion and action 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
79 Parkinson disease 💬
[2] DRD1, DRD2 💬 D07870 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
80 Parkinson disease 💬
[1] DRD2 💬 D03165 💬 Bromocriptine [2]  6 , 74 💬
81 Parkinson disease 💬
[1] DRD2 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
82 Parkinson disease 💬
[1] DRD2 💬 D08489 💬 Ropinirole [4]  2 ,  6 , 74, 309 💬
83 Pathways in cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
84 Pathways in cancer 💬
[2] ESR1, ESR2 💬 D07726 💬 Clomifene [1] 74 💬
85 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
86 Phospholipase D signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
87 PI3K-Akt signaling pathway 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
88 PI3K-Akt signaling pathway 💬
[1] PRL 💬 D03165 💬 Bromocriptine [2]  6 , 74 💬
89 PI3K-Akt signaling pathway 💬
[1] PRL 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
90 Platinum drug resistance 💬
[1] ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
91 Prolactin signaling pathway 💬
[2] ESR1, ESR2 💬 D07726 💬 Clomifene [1] 74 💬
92 Prolactin signaling pathway 💬
[1] PRL 💬 D03165 💬 Bromocriptine [2]  6 , 74 💬
93 Prolactin signaling pathway 💬
[1] PRL 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
94 Prostate cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
95 Proteoglycans in cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
96 Proteoglycans in cancer 💬
[1] ESR1 💬 D07726 💬 Clomifene [1] 74 💬
97 Rap1 signaling pathway 💬
[1] DRD2 💬 D03165 💬 Bromocriptine [2]  6 , 74 💬
98 Rap1 signaling pathway 💬
[1] DRD2 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
99 Rap1 signaling pathway 💬
[1] DRD2 💬 D07870 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
100 Rap1 signaling pathway 💬
[1] DRD2 💬 D08489 💬 Ropinirole [4]  2 ,  6 , 74, 309 💬
101 Rap1 signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
102 Ras signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
103 Regulation of actin cytoskeleton 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
104 Relaxin signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
105 Shigellosis 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
106 Thyroid hormone signaling pathway 💬
[1] ESR1 💬 D07726 💬 Clomifene [1] 74 💬
107 Tight junction 💬
[1] ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬