Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	TGF-beta signaling pathway 💬	[1] ACVR2A 💬	D09670 💬	Sotatercept	[2] 86, 284 💬
2	TGF-beta signaling pathway 💬	[2] ACVR2A, ACVR2B 💬	D10620 💬	Bimagrumab	[1] 15 💬
3	TGF-beta signaling pathway 💬	[1] ACVR2B 💬	D11701 💬	Luspatercept	[1] 60 💬
4	TGF-beta signaling pathway 💬	[1] IFNG 💬	D11120 💬	Emapalumab	[3] 49, 65, 107 💬
5	TGF-beta signaling pathway 💬	[1] IFNG 💬	D04242 💬	Fontolizumab	[1] 46 💬
6	TGF-beta signaling pathway 💬	[1] RGMA 💬	D11355 💬	Elezanumab	[1] 13 💬
7	TGF-beta signaling pathway 💬	[1] ROCK1 💬	D07941 💬	Fasudil	[4] 2 , 5 , 7 , 51 💬
8	TGF-beta signaling pathway 💬	[1] SMAD7 💬	D10956 💬	Mongersen	[2] 96, 97 💬
9	TGF-beta signaling pathway 💬	[3] TGFB1, TGFB2, TGFB3 💬	D09620 💬	Fresolimumab	[3] 51, 85, 222 💬
10	TGF-beta signaling pathway 💬	[1] TNF 💬	D02597 💬	Adalimumab	[17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬

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