Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Apelin signaling pathway 💬
 [1] PDE3B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
2 Apelin signaling pathway 💬
 [1] PDE3B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
3 Apelin signaling pathway 💬
 [1] PDE3B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
4 Apelin signaling pathway 💬
 [1] PDE3B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
5 Apelin signaling pathway 💬
 [1] PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
6 Apelin signaling pathway 💬
 [1] PDE3B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
7 Apelin signaling pathway 💬
 [1] PDE3B 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
8 Apelin signaling pathway 💬
 [1] PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
9 Apelin signaling pathway 💬
 [1] PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬
10 Apelin signaling pathway 💬
 [1] PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
11 Apelin signaling pathway 💬
 [1] PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
12 cAMP signaling pathway 💬
 [8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
13 cAMP signaling pathway 💬
 [8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
14 cAMP signaling pathway 💬
 [8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Aminophylline 💬 Aminophylline [1] 63 💬
15 cAMP signaling pathway 💬
 [8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
16 cAMP signaling pathway 💬
 [8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
17 cAMP signaling pathway 💬
 [7] PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Bucladesine 💬 Bucladesine [1] 246 💬
18 cAMP signaling pathway 💬
 [7] PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Flavoxate 💬 Flavoxate [1] 226 💬
19 cAMP signaling pathway 💬
 [2] PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
20 cAMP signaling pathway 💬
 [2] PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
21 cAMP signaling pathway 💬
 [2] PDE3A, PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬
22 cAMP signaling pathway 💬
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
23 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
24 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
25 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
26 cGMP-PKG signaling pathway 💬
 [5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
27 cGMP-PKG signaling pathway 💬
 [5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
28 cGMP-PKG signaling pathway 💬
 [3] PDE2A, PDE3A, PDE3B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
29 cGMP-PKG signaling pathway 💬
 [3] PDE2A, PDE3A, PDE3B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
30 cGMP-PKG signaling pathway 💬
 [2] PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
31 cGMP-PKG signaling pathway 💬
 [2] PDE3A, PDE3B 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
32 cGMP-PKG signaling pathway 💬
 [2] PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
33 cGMP-PKG signaling pathway 💬
 [2] PDE3A, PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬
34 Glucagon signaling pathway 💬
 [1] PDE3B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
35 Glucagon signaling pathway 💬
 [1] PDE3B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
36 Glucagon signaling pathway 💬
 [1] PDE3B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
37 Glucagon signaling pathway 💬
 [1] PDE3B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
38 Glucagon signaling pathway 💬
 [1] PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
39 Glucagon signaling pathway 💬
 [1] PDE3B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
40 Glucagon signaling pathway 💬
 [1] PDE3B 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
41 Glucagon signaling pathway 💬
 [1] PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
42 Glucagon signaling pathway 💬
 [1] PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬
43 Glucagon signaling pathway 💬
 [1] PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
44 Glucagon signaling pathway 💬
 [1] PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
45 Insulin signaling pathway 💬
 [1] PDE3B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
46 Insulin signaling pathway 💬
 [1] PDE3B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
47 Insulin signaling pathway 💬
 [1] PDE3B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
48 Insulin signaling pathway 💬
 [1] PDE3B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
49 Insulin signaling pathway 💬
 [1] PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
50 Insulin signaling pathway 💬
 [1] PDE3B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
51 Insulin signaling pathway 💬
 [1] PDE3B 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
52 Insulin signaling pathway 💬
 [1] PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
53 Insulin signaling pathway 💬
 [1] PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬
54 Insulin signaling pathway 💬
 [1] PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
55 Insulin signaling pathway 💬
 [1] PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
56 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
57 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
58 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
59 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
60 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
61 Metabolic pathways 💬
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
62 Metabolic pathways 💬
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
63 Metabolic pathways 💬
 [2] PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
64 Metabolic pathways 💬
 [2] PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
65 Metabolic pathways 💬
 [2] PDE3A, PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬
66 Metabolic pathways 💬
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
67 Morphine addiction 💬
 [17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
68 Morphine addiction 💬
 [17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
69 Morphine addiction 💬
 [17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
70 Morphine addiction 💬
 [9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
71 Morphine addiction 💬
 [9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
72 Morphine addiction 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
73 Morphine addiction 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
74 Morphine addiction 💬
 [2] PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
75 Morphine addiction 💬
 [2] PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
76 Morphine addiction 💬
 [2] PDE3A, PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬
77 Morphine addiction 💬
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
78 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
79 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
80 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
81 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
82 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
83 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
84 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
85 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
86 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬
87 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
88 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
89 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
90 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
91 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
92 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
93 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
94 Purine metabolism 💬
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
95 Purine metabolism 💬
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
96 Purine metabolism 💬
 [2] PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
97 Purine metabolism 💬
 [2] PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
98 Purine metabolism 💬
 [2] PDE3A, PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬
99 Purine metabolism 💬
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
100 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
101 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
102 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
103 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
104 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
105 Regulation of lipolysis in adipocytes 💬
 [1] PDE3B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
106 Regulation of lipolysis in adipocytes 💬
 [1] PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
107 Regulation of lipolysis in adipocytes 💬
 [1] PDE3B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
108 Regulation of lipolysis in adipocytes 💬
 [1] PDE3B 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
109 Regulation of lipolysis in adipocytes 💬
 [1] PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
110 Regulation of lipolysis in adipocytes 💬
 [1] PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬
111 Renin secretion 💬
 [6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
112 Renin secretion 💬
 [6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
113 Renin secretion 💬
 [6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
114 Renin secretion 💬
 [4] ADORA1, PDE1B, PDE3A, PDE3B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
115 Renin secretion 💬
 [4] ADORA1, PDE1B, PDE3A, PDE3B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
116 Renin secretion 💬
 [5] PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
117 Renin secretion 💬
 [5] PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
118 Renin secretion 💬
 [2] PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
119 Renin secretion 💬
 [2] PDE3A, PDE3B 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
120 Renin secretion 💬
 [2] PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
121 Renin secretion 💬
 [2] PDE3A, PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬

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