Propofol ( DrugBank: Propofol )
8 diseases
ID | Disease name (Link within this page) | Number of trials |
---|---|---|
6 | Parkinson disease | 8 |
21 | Mitochondrial disease | 1 |
22 | Moyamoya disease | 1 |
34 | Neurofibromatosis | 1 |
46 | Malignant rheumatoid arthritis | 1 |
70 | Spinal stenosis | 2 |
98 | Eosinophilic gastrointestinal disease | 1 |
296 | Biliary atresia | 2 |
6. Parkinson disease
Clinical trials : 2,307 / Drugs : 2,007 - (DrugBank : 349) / Drug target genes : 188 - Drug target pathways : 199
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | ChiCTR2000039697 | 2020-11-15 | 2020-11-06 | Application of etomidate in deep brain stimulation under general anesthesia for Parkinson's disease | Application of etomidate in deep brain stimulation under general anesthesia for Parkinson's disease | Parkinson Disease | Experimental group:Etomidate-based anesthesia;Control group: Propofol-based anesthesia; | Department of Anesthesiology, the First Affiliated Hospital of Sun Yat-Sen University | NULL | Recruiting | 18 | 80 | Both | Experimental group:30;Control group:30; | Phase 4 | China |
2 | NCT04502550 (ClinicalTrials.gov) | October 15, 2020 | 30/7/2020 | Brain Networks and Consciousness | Subcortical-cortical Network Dynamics of Anesthesia and Consciousness | Loss of Consciousness;Parkinson Disease;Essential Tremor;Anesthesia | Drug: Propofol | University of Texas Southwestern Medical Center | University of California, Los Angeles | Recruiting | 18 Years | N/A | All | 144 | United States | |
3 | ChiCTR1900021760 | 2019-03-09 | 2019-03-08 | Effect-site concentration of remifentanil for I-gel insertion in male patients with Parkinson’s disease undergoing deep brain stimulator implantation during target-controlled infusion of propofol | Effect-site concentration of remifentanil for I-gel insertion in male patients with Parkinson’s disease undergoing deep brain stimulator implantation during target-controlled infusion of propofol | Parkinson’s disease | Parkinson’s disease:propofol and remifentanil;Non-Parkinson’s disease:propofol and remifentanil; | The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China | NULL | Recruiting | 40 | 64 | Male | Parkinson’s disease:25;Non-Parkinson’s disease:25; | N/A | China |
4 | ChiCTR1800014542 | 2018-01-22 | 2018-01-20 | Up-down sequential testing of propofol - induced half-effective dose ( ed50 ) in patients with Parkinson's disease and non - Parkinson's disease | Up-down sequential testing of propofol - induced half-effective dose ( ed50 ) in patients with Parkinson's disease and non - Parkinson's disease | Parkinson's Disease | PD group:propofol;NPD group:propofol; | Xuanwu Hospital of CCMU | NULL | Recruiting | 18 | 65 | Both | PD group:40;NPD group:40; | China | |
5 | ChiCTR-IOR-16010168 | 2016-12-20 | 2016-12-15 | Propofol-remifetanyl vs dexmedetomidine continous infusion for deep brain stimulation implantation | Propofol-remifetanyl vs dexmedetomidine continous infusion for deep brain stimulation implantation | Parkinson's Disease | propofol-remifentanyl group:propofol-remifentany infusion for monitored anesthesia care during awake deep brain stimulation surgery;dexmedetomidine group:dexmedetomidine infusion for monitored anesthesia care during awake deep brain stimulation surgery; | West China Hospital, Sichuan University | NULL | Recruiting | 18 | Both | propofol-remifentanyl group:25;dexmedetomidine group:25; | China | ||
6 | NCT02256319 (ClinicalTrials.gov) | September 2014 | 30/9/2014 | Dexmedetomidine vs Propofol on the Recordings of Deep Brain Activity Measured Through Implanted Stimulators | Effects of Dexmedetomidine vs Propofol on the Recordings of Deep Brain Activity (Local Field Potentials) Measured Through Implanted Stimulators | Parkinson's Disease | Drug: Dexmedetomidine;Drug: Propofol | Clinica Universidad de Navarra, Universidad de Navarra | NULL | Completed | 18 Years | N/A | Both | 12 | Phase 4 | Spain |
7 | EUCTR2014-000868-17-ES (EUCTR) | 26/06/2014 | 17/03/2014 | Effect of dexmedetomidine vs propofol on basal ganglia activity (local field potentials) recorded through implanted stimulators | Effect of dexmedetomidine vs propofol on basal ganglia activity (local field potentials) recorded through implanted stimulators | Parkinson's disease MedDRA version: 16.1;Level: LLT;Classification code 10013113;Term: Disease Parkinson's;System Organ Class: 100000004852;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | Trade Name: Dexdor Product Name: Dexdor INN or Proposed INN: DEXMEDETOMIDINE Other descriptive name: DEXMEDETOMIDINA Trade Name: Propofol-Lipuro Product Name: Propofol-Lipuro INN or Proposed INN: PROPOFOL Other descriptive name: PROPOFOL | Clínica Universidad de Navarra/Universidad de Navarra | NULL | Not Recruiting | Female: yes Male: yes | Spain | ||||
8 | NCT00615472 (ClinicalTrials.gov) | October 2003 | 9/1/2008 | Intravenous Versus Inhalational Anesthesia in Parkinson's Disease | Intravenous General Anesthesia Versus Inhalational General Anesthesia in Parkinson's Disease | Parkinson's Disease | Drug: Isoflurane;Drug: Remifentanil;Drug: Propofol | Columbia University | NULL | Terminated | 18 Years | N/A | All | 58 | N/A | United States |
21. Mitochondrial disease
Clinical trials : 39 / Drugs : 42 - (DrugBank : 32) / Drug target genes : 47 - Drug target pathways : 67
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | NCT02053766 (ClinicalTrials.gov) | January 10, 2014 | 31/1/2014 | Anesthesia in Patients With Mitochondrial Disease | Anesthesia in Patients With Mitochondrial Disease | Mitochondrial Diseases | Drug: Sevoflurane;Drug: Dexmedetomidine;Drug: Propofol | The University of Texas Health Science Center, Houston | NULL | Recruiting | N/A | 17 Years | All | 60 | N/A | United States |
22. Moyamoya disease
Clinical trials : 17 / Drugs : 22 - (DrugBank : 17) / Drug target genes : 33 - Drug target pathways : 45
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | ChiCTR1900027197 | 2019-05-01 | 2019-11-04 | Study on the protective effect of desflurane combined with propofol on the brain of patients with moyamoya disease undergoing cerebral revascularization | Study for the protective effect of desflurane on the brain of patients with moyamoya disease | Moyamoya disease | Group D:Desflurane for anesthesia maintenance;GroupP:Propofol;GroupPD:Desflurane and propofol; | The First Affiliated Hospital of Zhengzhou University | NULL | Completed | 20 | 65 | Both | Group D:30;GroupP:30;GroupPD:30; | Phase 4 | China |
34. Neurofibromatosis
Clinical trials : 133 / Drugs : 186 - (DrugBank : 67) / Drug target genes : 79 - Drug target pathways : 190
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | NCT03513757 (ClinicalTrials.gov) | March 4, 2018 | 4/2/2018 | Dexmedetomidine and Propofol for Pediatric MRI Sedation | An Observer-blinded Randomized Study of Propofol Infusion vs Bolus Dexmedetomidine and Propofol Sedation for Pediatric Magnetic Resonance Imaging | Headache;Tumor;Seizure Disorder;Neurofibromatoses;Hydrocephalus;Abdominal Neoplasm;Spine Deformity | Drug: propofol;Drug: Dexmedetomidine;Drug: Glycopyrrolate;Drug: Lidocaine 1% Injectable Solution;Drug: Nitrous Oxide;Drug: Sevoflurane | Medical College of Wisconsin | NULL | Completed | 12 Months | 60 Months | All | 40 | Phase 4 | United States |
46. Malignant rheumatoid arthritis
Clinical trials : 4,356 / Drugs : 2,567 - (DrugBank : 415) / Drug target genes : 192 - Drug target pathways : 228
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | EUCTR2016-002035-15-FI (EUCTR) | 20/05/2016 | 12/05/2016 | Outcome after total knee endoprosthesis under general or regional anesthesia, a randomized study | Outcome after total knee arthroplasty under general or spinal anesthesia, a randomized study - Outcome after total knee arthroplasty under general or spinal anesthesia | Patients undego total knee arthroplasty operation in general or spinal anaesthesia because of osteoarthritis, rheumatoid arthritis or other degenerative condition of the knee MedDRA version: 19.0;Level: LLT;Classification code 10031174;Term: Osteoarthrosis;System Organ Class: 100000004859 MedDRA version: 19.0;Classification code 10031158;Term: Osteo arthritis knees;System Organ Class: 100000004859;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | Trade Name: Bicain spinal INN or Proposed INN: bupivacaine hydrochloride Other descriptive name: BUPIVACAINE HYDROCHLORIDE Trade Name: Propolipid INN or Proposed INN: propofol Other descriptive name: PROPOFOL | Helsinki University Central Hospital | NULL | Not Recruiting | Female: yes Male: yes | 400 | Phase 4 | Finland |
70. Spinal stenosis
Clinical trials : 95 / Drugs : 169 - (DrugBank : 61) / Drug target genes : 68 - Drug target pathways : 90
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | ChiCTR2200058808 | 2022-04-16 | 2022-04-17 | Effect of multimodal brain monitoring-guided anesthesia on incidence of postoperative cognitive dysfunction in elderly following spinal surgery | Effect of multimodal brain monitoring-guided anesthesia on incidence of postoperative cognitive dysfunction in elderly following spinal surgery | Thoracic/lumbar spinal stenosis or lumbar disc herniation | BIS guided anesthesia management group:The dosage of propofol is adjusted guided by BIS value;Multimodal brain monitoring-guided anesthesia management group:Multimodal brain monitoring-guided anesthesia; | Beijing Municipal Geriatric Medical Research Center | NULL | Recruiting | 65 | 100 | Both | BIS guided anesthesia management group:94;Multimodal brain monitoring-guided anesthesia management group:94; | China | |
2 | NCT04992572 (ClinicalTrials.gov) | December 1, 2021 | 21/7/2021 | Study Comparing Local/ MAC Anesthesia in Lumbar Decompression | Randomized Study Comparing Local/ MAC Anesthesia to General for 1-3 Level Lumbar Decompressions | Lumbar Spinal Stenosis | Drug: Propofol Injection;Drug: Lidocaine Hydrochloride, Injectable | Stanford University | NULL | Recruiting | 40 Years | 95 Years | All | 100 | Early Phase 1 | United States |
98. Eosinophilic gastrointestinal disease
Clinical trials : 172 / Drugs : 149 - (DrugBank : 39) / Drug target genes : 38 - Drug target pathways : 135
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | NCT02038894 (ClinicalTrials.gov) | December 2009 | 1/5/2013 | Comparing Anesthetic Techniques in Children Having Esophagogastroduodenoscopies | Comparison Of Different Anesthetic Techniques In Children Undergoing Esophagogastroduodenoscopies | Eosinophilic Esophagitis | Drug: Intubated with Sevoflurane (IS);Drug: Intubated with Propofol (IP);Drug: Zofran - no intubation;Drug: Propofol | Children's Hospital Medical Center, Cincinnati | NULL | Completed | 1 Year | 12 Years | All | 179 | N/A | United States |
296. Biliary atresia
Clinical trials : 71 / Drugs : 70 - (DrugBank : 39) / Drug target genes : 35 - Drug target pathways : 60
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | ChiCTR-IOR-17013585 | 2018-06-14 | 2017-11-24 | Comparison of renal injury in children with liver transplantation under combined anesthesia with sevoflurane and propofol | The influence of sevoflurane and propofol on acute kidney injury in pediatric living donor liver transplantion | Congenital biliary atresia | P:Propofol compound anesthesia;Se:Sevoflurane compound anesthesia; | Tianjin First Central Hospital | NULL | Recruiting | 0.5 | 2 | Both | P:60;Se:60; | China | |
2 | ChiCTR1800015778 | 2018-04-20 | 2018-04-20 | Myocardial protection in pediatric patients undergoing liver transplantation | Myocardial protective strategies of pediatric liver transplantation with biliary atresia | Congenital biliary atresia | Propofol:Propofol compound anesthesia;Sev:Sev compound anesthesia; | Tianjin First Center Hospital | NULL | Recruiting | 0 | 2 | Both | Propofol:60;Sev:60; | China |