Drug Description in Trials / DrugBank / KEGG DRUG /

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No.	薬物名（臨床試験情報から抽出）	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY	指定難病告示番号
1	(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4’-	-	-	-	-	1件: 79
2	1,2-Dihexadecanoyl-sn-Glycero-3-Phospho-(1-raac-glycerol)	1件: Glycerin	1件: D00028	-	-	1件: 79
3	AAV directed hLDLR gene therapy	-	-	-	-	1件: 79
4	AAV8.TBG.hLDLR	-	-	-	-	1件: 79
5	Acetate	1件: Acetate	-	-	-	43件: 1, 2, 6, 10, 13, 35, 40, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 162, 171, 206, 222, 224, 225, 227, 235, 265, 288, 298, 299
6	AEGR-733	-	-	-	-	1件: 79
7	AK102	-	-	-	-	1件: 79
8	AKCEA-ANGPTL3-LRX	-	-	-	-	2件: 79, 265
9	ALIROCUMAB	1件: Alirocumab	1件: D10335	1件: PCSK9 💬	1件: Cholesterol metabolism 💬	1件: 79
10	Alirocumab SAR236553 (REGN727)	1件: Alirocumab	1件: D10335	1件: PCSK9 💬	1件: Cholesterol metabolism 💬	1件: 79
11	ALN-60212	-	-	-	-	1件: 79
12	ALN-PCSSC	1件: Inclisiran	1件: D11931	1件: PCSK9 💬	1件: Cholesterol metabolism 💬	1件: 79
13	AMG 145	-	-	-	-	1件: 79
14	AMG145	-	-	-	-	1件: 79
15	ANACETRAPIB	1件: Anacetrapib	1件: D08855	1件: CETP 💬	1件: Cholesterol metabolism 💬	1件: 79
16	Atorvastatin	1件: Atorvastatin	3件: D00258 , D00887 , D07474	1件: HMGCR 💬	4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬	18件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
17	Calcium	1件: Calcium	-	-	-	30件: 3, 6, 13, 15, 19, 46, 49, 51, 53, 56, 68, 75, 79, 84, 93, 94, 95, 96, 97, 186, 214, 215, 222, 224, 235, 256, 265, 274, 298, 299
18	Calcium rosuvastatin	2件: Calcium, Rosuvastatin	2件: D01915 , D08492	1件: HMGCR 💬	4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬	1件: 79
19	CER-001	-	-	-	-	1件: 79
20	Cholestyramine	1件: Cholestyramine	-	-	-	2件: 13, 79
21	Comparator: ezetimibe	1件: Ezetimibe	1件: D01966	1件: NPC1L1 💬	1件: Fat digestion and absorption 💬	2件: 79, 260
22	Crestor	1件: Rosuvastatin	2件: D01915 , D08492	1件: HMGCR 💬	4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬	3件: 49, 79, 299
23	Crestor Film-Coated Tablet	1件: Rosuvastatin	2件: D01915 , D08492	1件: HMGCR 💬	4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬	1件: 79
24	Crestor Tablets (calcium rosuvastatin) Film-Coated tablets	2件: Calcium, Rosuvastatin	2件: D01915 , D08492	1件: HMGCR 💬	4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬	1件: 79
25	Current lipid-lowering treatment	-	-	-	-	1件: 79
26	Dextran	1件: Dextran	1件: D00060	-	-	5件: 2, 62, 79, 96, 97
27	Dextran sulfate adsorption	2件: Dextran, Sulfate ion	1件: D00060	-	-	1件: 79
28	DPPG	-	-	-	-	1件: 79
29	EVINACUMAB	1件: Evinacumab	1件: D11753	1件: ANGPTL3 💬	1件: Cholesterol metabolism 💬	1件: 79
30	Evinacumab (REGN1500)	1件: Evinacumab	1件: D11753	1件: ANGPTL3 💬	1件: Cholesterol metabolism 💬	1件: 79
31	EVOLOCUMAB	1件: Evolocumab	1件: D10557	1件: PCSK9 💬	1件: Cholesterol metabolism 💬	2件: 79, 222
32	Evolocumab (AMG 145)	1件: Evolocumab	1件: D10557	1件: PCSK9 💬	1件: Cholesterol metabolism 💬	1件: 79
33	Ezetimibe	1件: Ezetimibe	1件: D01966	1件: NPC1L1 💬	1件: Fat digestion and absorption 💬	4件: 49, 79, 93, 260
34	Fenofibrate	1件: Fenofibrate	1件: D00565	1件: PPARA 💬	10件: Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬	5件: 8, 79, 93, 94, 265
35	Fluvastatin	1件: Fluvastatin	2件: D00892 , D07983	1件: HMGCR 💬	4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬	3件: 79, 218, 222
36	Gemcabene	1件: Gemcabene	-	-	-	2件: 79, 265
37	Glycerol	1件: Glycerin	1件: D00028	-	-	5件: 6, 13, 79, 316, 317
38	Heparin	1件: Heparin	1件: D07510	1件: SERPINC1 💬	1件: Complement and coagulation cascades 💬	12件: 47, 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317
39	Heparin-induced extracorporeal LDL precipitation	1件: Heparin	1件: D07510	1件: SERPINC1 💬	1件: Complement and coagulation cascades 💬	1件: 79
40	IBI306	-	-	-	-	1件: 79
41	Implitapide	1件: Implitapide	-	-	-	1件: 79
42	Inclisiran	1件: Inclisiran	1件: D11931	1件: PCSK9 💬	1件: Cholesterol metabolism 💬	1件: 79
43	Inclisiran for injection	1件: Inclisiran	1件: D11931	1件: PCSK9 💬	1件: Cholesterol metabolism 💬	1件: 79
44	Inclisiran Sodium	1件: Inclisiran	1件: D11931	1件: PCSK9 💬	1件: Cholesterol metabolism 💬	1件: 79
45	ISIS 301012	-	-	-	-	1件: 79
46	ISIS 301012 phosphorothioate oligonucleotide	-	-	-	-	1件: 79
47	ISIS 703802	-	-	-	-	1件: 79
48	JS002	-	-	-	-	1件: 79
49	KJX839	-	-	-	-	1件: 79
50	Lapaquistat	1件: Lapaquistat	-	-	-	1件: 79
51	Lapaquistat acetate and current lipid-lowering treatment	2件: Acetate, Lapaquistat	-	-	-	1件: 79
52	Lerodalcibep	-	-	-	-	1件: 79
53	LIB003	-	-	-	-	1件: 79
54	Lojuxta	1件: Lomitapide	1件: D09637	1件: MTTP 💬	1件: Fat digestion and absorption 💬	1件: 79
55	Lojuxta 10 mg hard capsules	1件: Lomitapide	1件: D09637	1件: MTTP 💬	1件: Fat digestion and absorption 💬	1件: 79
56	Lojuxta 20 mg hard capsules	1件: Lomitapide	1件: D09637	1件: MTTP 💬	1件: Fat digestion and absorption 💬	1件: 79
57	Lojuxta 5 mg hard capsules	1件: Lomitapide	1件: D09637	1件: MTTP 💬	1件: Fat digestion and absorption 💬	1件: 79
58	LOMITAPIDE	1件: Lomitapide	1件: D09637	1件: MTTP 💬	1件: Fat digestion and absorption 💬	1件: 79
59	Lomitapide 2mg hard capsules	1件: Lomitapide	1件: D09637	1件: MTTP 💬	1件: Fat digestion and absorption 💬	1件: 79
60	Lovastatin	1件: Lovastatin	1件: D00359	1件: HMGCR 💬	4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬	11件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310
61	MBX-8025	-	-	-	-	3件: 79, 93, 94
62	MBX-8025 50 mg (Dose Escalation Period 1)	-	-	-	-	1件: 79
63	MBX-8025 50 mg or 100 mg (Dose Escalation Period 2)	-	-	-	-	1件: 79
64	MBX-8025 50 mg, 100 mg or 200 mg (Dose Escalation Period 3)	-	-	-	-	1件: 79
65	Mipomersen	1件: Mipomersen	-	-	-	1件: 79
66	MK-0859	-	-	-	-	1件: 79
67	Nicotinic acid	1件: Niacin	1件: D00049	-	-	1件: 79
68	Omega-3	1件: Omega-3 fatty acids	-	-	-	7件: 13, 46, 49, 66, 79, 96, 299
69	Omega-3 fatty acids	1件: Omega-3 fatty acids	-	-	-	2件: 13, 79
70	Phospholipids	1件: Omega-3 fatty acids	-	-	-	1件: 79
71	Placebo	-	-	-	-	27件: 3, 5, 6, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276
72	Praluent	1件: Alirocumab	1件: D10335	1件: PCSK9 💬	1件: Cholesterol metabolism 💬	1件: 79
73	Pravastatin	1件: Pravastatin	2件: D00893 , D08410	1件: HMGCR 💬	4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬	9件: 13, 46, 49, 67, 79, 96, 164, 265, 333
74	PRD7255830	-	-	-	-	1件: 79
75	PRD7255977	-	-	-	-	1件: 79
76	PRD7256003	-	-	-	-	1件: 79
77	Prednisone	1件: Prednisone	1件: D00473	1件: NR3C1 💬	1件: Neuroactive ligand-receptor interaction 💬	48件: 2, 6, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
78	R727	-	-	-	-	1件: 79
79	Recombinant Human Apolipoprotein	-	-	-	-	1件: 79
80	Recombinant Human Apolipoprotein A-I	-	-	-	-	1件: 79
81	Recombinant Human Apolipoprotein A-I/Phospholipids Complex	1件: Omega-3 fatty acids	-	-	-	1件: 79
82	Recombinant human apolipoprotein a1	-	-	-	-	1件: 79
83	REGN1500	-	-	-	-	1件: 79
84	REGN1500 250 mg SC/15 mg/kg IV/450 mg SC	-	-	-	-	1件: 79
85	REGN7272	-	-	-	-	1件: 79
86	Repatha	1件: Evolocumab	1件: D10557	1件: PCSK9 💬	1件: Cholesterol metabolism 💬	1件: 79
87	Repatha (evolocumab)	1件: Evolocumab	1件: D10557	1件: PCSK9 💬	1件: Cholesterol metabolism 💬	1件: 79
88	Repatha 140 mg Solution for Injection in Pre-filled Pen	1件: Evolocumab	1件: D10557	1件: PCSK9 💬	1件: Cholesterol metabolism 💬	1件: 79
89	Repatha 140 mg soluzione per iniezione in penna preriempita.	1件: Evolocumab	1件: D10557	1件: PCSK9 💬	1件: Cholesterol metabolism 💬	1件: 79
90	Repatha 420 mg solution for injection in cartridge	1件: Evolocumab	1件: D10557	1件: PCSK9 💬	1件: Cholesterol metabolism 💬	1件: 79
91	Repatha 420 mg soluzione per iniezione in cartuccia	1件: Evolocumab	1件: D10557	1件: PCSK9 💬	1件: Cholesterol metabolism 💬	1件: 79
92	Rosuvastatin	1件: Rosuvastatin	2件: D01915 , D08492	1件: HMGCR 💬	4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬	11件: 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
93	Rosuvastatin 20mg	1件: Rosuvastatin	2件: D01915 , D08492	1件: HMGCR 💬	4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬	1件: 79
94	ROSUVASTATIN CALCIUM	2件: Calcium, Rosuvastatin	2件: D01915 , D08492	1件: HMGCR 💬	4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬	4件: 49, 79, 97, 299
95	SAR236553	-	-	-	-	1件: 79
96	Sfingomielina	-	-	-	-	1件: 79
97	SHR-1209	-	-	-	-	1件: 79
98	Simvastatin	1件: Simvastatin	1件: D00434	1件: HMGCR 💬	4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬	21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
99	Single intravenous (IV) dose of human Low Density Lipoprotein Receptor (LDLR) Gene Therapy	-	-	-	-	1件: 79
100	Sphingomyelin	-	-	-	-	1件: 79
101	Standard of Care	-	-	-	-	10件: 6, 13, 46, 49, 51, 63, 64, 79, 171, 271
102	Statins	-	-	-	-	2件: 46, 79
103	Sulfate	1件: Sulfate ion	-	-	-	27件: 2, 3, 6, 11, 13, 26, 28, 34, 36, 46, 49, 53, 60, 64, 66, 79, 85, 86, 96, 111, 218, 222, 226, 265, 296, 297, 299
104	TAK-475	1件: TAK-475	-	-	-	1件: 79
105	ZD4522	-	-	-	-	1件: 79