Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 Acetaminophen
(Synonym: Arthritis Pain Reliever Extended Release)		[5] Acetaminophen; Oxycodone/Acetaminophen; PARACETAMOL; Tylenol; Ultracet[1] D00217 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[18] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
2 Acetazolamide
(Synonym: Acetazolamide Extended-release)		[1] ACETAZOLAMIDE[2] D00218 ,
D01196 		[13] CA1,
CA12,
CA13,
CA14,
CA2,
CA3,
CA4,
CA5A,
CA5B,
CA6,
CA7,
CA8,
CA9 💬		[7] Bile secretion, Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Nitrogen metabolism, Pancreatic secretion, Proximal tubule bicarbonate reclamation 💬[8] 13, 86, 90, 115, 154, 155, 225, 230
3 Acetylsalicylic acid
(Synonym: Aspirin Coated for Delayed Release Extra Strength)		[2] ACETYLSALICYLIC ACID; Aspirin[1] D00109 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251
4 Alfuzosin
(Synonym: Alfuzosin Hydrochloride extended release)		[1] Alfuzosin[2] D01692 ,
D07124 		[1] ADRA1A 💬[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 13
5 alpha-Tocopherol acetate
(Synonym: Icaps Time Release)		[3] Tocopherol acetate; TOCOPHERYL ACETATE; Vitamin E---[2] 49, 206
6 Alprazolam
(Synonym: Alprazolam Extended-release)		[1] Alprazolam[1] D00225 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[2] 8, 75
7 Amoxicillin
(Synonym: Amoxicillin Extended-Release)		[4] Amoxicilina; Amoxicillin; Amoxycillin; Augmentin[3] D00229 ,
D02925 ,
D07452 		--[9] 6, 19, 46, 63, 84, 96, 97, 222, 299
8 Ascorbic acid
(Synonym: Vitamin C 1000mg Time Release Form)		[4] Acidum ascorbicum; Ascorbic acid; Iron; Vitamin C[1] D00018 --[8] 10, 97, 192, 206, 210, 211, 212, 298
9 Beta carotene
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		[3] Beta carotene; Beta-Carotene; BETACAROTENE[1] D03101 --[2] 13, 96
10 Biotin
(Synonym: Timed Release B Complex 100 Srt)		[4] Biotin; Biotina; D-BIOTIN; Vitamin B7[1] D00029 --[5] 2, 8, 10, 13, 20
11 Bisacodyl
(Synonym: Delayed Release Laxative Bisacodyl)		[1] Bisacodyl[1] D00245 --[1] 13
12 Bupropion
(Synonym: Bupropion Hydrochloride Extended Release SR)		[2] Bupropion; Bupropion Hydrochloride[3] D00817 (Name: BUPROPION HYDROCHLORIDE EXTENDED RELEASE),
D07591 ,
D07938 		[2] SLC6A2,
SLC6A3 💬		[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬[5] 8, 18, 21, 96, 171
13 Calcium
(Synonym: Timed Release Vita-vim Srt)		[2] Calcio; Calcium---[30] 3, 6, 13, 15, 19, 46, 49, 51, 53, 56, 68, 75, 79, 84, 93, 94, 95, 96, 97, 186, 214, 215, 222, 224, 235, 256, 265, 274, 298, 299
14 Calcium carbonate
(Synonym: Swiss One Timed Release Tab)		[3] Calcio carbonato; Calcium; Calcium carbonate[2] D00932 ,
D10802 		--[9] 13, 19, 46, 53, 75, 96, 235, 274, 299
15 Chlorpheniramine
(Synonym: Tussionex Pennkinetic Extended-Release)		[1] Clorfenamina[4] D00665 ,
D00668 ,
D07398 ,
D07803 		[1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[1] 14
16 Choline
(Synonym: Timed Release Vita-vim Srt)		[1] Choline[1] D07690 --[4] 93, 171, 193, 299
17 Chromium
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		[1] Chromium---[1] 46
18 Clarithromycin
(Synonym: Clarithromycin extended release)		[1] Clarithromycin[1] D00276 --[8] 6, 63, 84, 96, 97, 222, 228, 299
19 Clavulanic acid
(Synonym: Amoxicillin and Clavulanate Potassium Extended Release)		[4] AMOXICILLIN; Augmentin; Clavulanate; CLAVULANIC ACID[1] D07711 --[1] 299
20 Clonidine
(Synonym: Clonidine hydrochloride extended-release)		[4] Clonidin; Clonidina; Clonidine; CLONIDINE HYDROCHLORIDE[2] D00281 ,
D00604 		[3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[4] 6, 65, 70, 78
21 Copper
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		[2] Copper; Nicotinamide---[4] 2, 169, 170, 171
22 Cyanocobalamin
(Synonym: Energy 80 Prolonged Release Tab)		[2] Cianocobalamina; Vitamin B12[4] D00166 ,
D03615 ,
D03616 ,
D03617 		--[5] 6, 13, 201, 229, 299
23 Cysteamine
(Synonym: PROCYSBI Delayed-release)		[8] 2-aminoethanethiol; Beta-Mercaptoethylamine; CYSTADROPS; Cystagon; Cysteamine; Mercaptamina; Mercaptamine; PROCYSBI[2] D03634 ,
D03635 		--[4] 8, 19, 21, 299
24 Darifenacin
(Synonym: Darifenacin Hydrobromide Extended-Release)		[2] Darifenacin; Emselex[2] D01699 ,
D03654 		[1] CHRM3 💬[11] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬[2] 6, 13
25 Dextromethorphan
(Synonym: Tylenol Cold Rapid Release)		[4] Dextromethorphan; Dextromethorphan hydrobromide; Dextrometorfano; Nuedexta[3] D00848 ,
D03742 ,
D03744 		[6] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
26 Diclofenac
(Synonym: Lidovix Delayed Release)		[3] Diclofenac; Diclofenac sodium; Diclofenac SR[3] D00903 ,
D00904 (Name: DICLOFENAC SODIUM DELAYED RELEASE),
D07816 		[2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[5] 13, 34, 46, 78, 271
27 Diltiazem
(Synonym: Diltiazem HydrochlorideExtended Release Extended Release)		[2] Diltiazem; Diltiazem Hydrochloride[3] D00616 (Name: DILTIAZEM HYDROCHLORIDE EXTENDED RELEASE),
D03830 ,
D07845 		[4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 51, 58, 86
28 Dimethyl fumarate
(Synonym: Sandoz Dimethyl Fumarate Delayed-release Capsules)		[3] DIMETHYL FUMARATE; Dimethylfumarat; TECFIDERA[1] D03846 [1] KEAP1 💬[6] Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Parkinson disease, Pathways in cancer, Ubiquitin mediated proteolysis 💬[5] 13, 49, 51, 86, 296
29 Diphenhydramine
(Synonym: Pain Relief PM Rapid Release)		[2] Diphenhydramine; Diphenhydramine hydrochloride[6] D00300 ,
D00669 ,
D02419 ,
D03285 ,
D03360 ,
D03854 		[1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[10] 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
30 Dipyridamole
(Synonym: Asprin and Extended-release Dipyridamole)		[1] Dipyridamole[1] D00302 [2] PDE4A,
PDE5A 💬		[6] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 46, 49, 51, 66, 96, 224
31 Donepezil
(Synonym: Memantine and Donepezil Hydrochlorides Extended-release)		[3] ARICEPT; Donepezil; Donepezil hydrochloride[2] D00670 ,
D07869 		[1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[9] 5, 6, 13, 46, 78, 124, 127, 156, 206
32 Doxycycline
(Synonym: Doxycycline Hyclate Delayed Release)		[4] Doxycyclin; Doxycycline; Doxycycline Hyclate; Doxycycline Tablets[5] D00307 ,
D02129 ,
D03903 ,
D03904 ,
D07876 		--[16] 13, 23, 28, 46, 84, 85, 89, 96, 97, 158, 161, 162, 167, 227, 280, 299
33 Duloxetine
(Synonym: Duloxetine Delayed-Release)		[3] CYMBALTA; Duloxetine; Duloxetine hydrochloride[2] D01179 ,
D07880 		[2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 13
34 Ergocalciferol
(Synonym: Timed Release Vita-vim Srt)		[3] Ergocalciferol; Vitamin D; Vitamin D2[1] D00187 [1] VDR 💬[5] Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬[6] 46, 49, 84, 96, 97, 299
35 Erythromycin
(Synonym: Eryc Delayed-release Capsules)		[1] Erythromycin[9] D00140 ,
D00851 ,
D01361 ,
D02009 ,
D02184 ,
D02523 ,
D02524 ,
D02525 ,
D04054 		--[5] 6, 36, 164, 228, 291
36 Ferrous sulfate anhydrous
(Synonym: Iron 35mg Sustained Release Dietary Supplement)		[0] ---[1] 46
37 Folic acid
(Synonym: Energy 80 Prolonged Release Tab)		[5] Acide folique; Folate; Folic acid; Multivitamin; Nicotinamide[1] D00070 --[6] 6, 13, 41, 46, 49, 84
38 Guanfacine
(Synonym: Guanfacine Extended-Release)		[1] Guanfacine[2] D00606 (Name: GUANFACINE EXTENDED-RELEASE),
D08031 		[1] ADRA2A 💬[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[1] 193
39 Hydromorphone
(Synonym: Hydromorph Contin-controlled Release Cap - 6mg)		[1] Hydromorphone[2] D00839 ,
D08047 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[1] 70
40 Ibuprofen
(Synonym: Ibuprofen Immediate release)		[2] Ibuprofen; IBUPROFEN 200MG[4] D00126 ,
D01122 ,
D04490 ,
D06606 		[2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[7] 13, 46, 65, 107, 113, 271, 299
41 Indomethacin
(Synonym: Indomethacin extended-release)		[2] INDOMETACIN; Indomethacin[3] D00141 (Name: INDOMETHACIN EXTENDED-RELEASE),
D01565 ,
D02110 		[2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[3] 225, 271, 298
42 Inositol
(Synonym: Timed Release B Complex 100 Srt)		[1] Inositol[1] D08079 --[2] 96, 97
43 Iodine
(Synonym: Swiss One Timed Release Tab)		[2] Iodine; Iodo[1] D00108 --[3] 28, 46, 88
44 Iron
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		[1] Iron---[6] 18, 96, 97, 238, 254, 284
45 Ketoprofen
(Synonym: Oruvail Extended Release)		[1] Ketoprofen[1] D00132 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 46
46 Lamotrigine
(Synonym: Lamotrigine Extended Release)		[2] Lamictal; LAMOTRIGINE[1] D00354 (Name: LAMOTRIGINE EXTENDED RELEASE)[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[5] 13, 34, 38, 114, 144
47 Lansoprazole
(Synonym: Lansoprazole Delayed-release Orally Disintegrating)		[1] Lansoprazole[1] D00355 [2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[7] 63, 71, 85, 98, 166, 222, 299
48 Levetiracetam
(Synonym: Levetiracetam Extended Release)		[2] KEPPRA; Levetiracetam[1] D00709 (Name: LEVETIRACETAM EXTENDED RELEASE)[1] SV2A 💬[1] ECM-receptor interaction 💬[5] 2, 4, 6, 13, 307
49 Lidocaine
(Synonym: Lidovix Delayed Release)		[4] Aloe; Lidocaine; Lignocaine; Xylocaine[3] D00358 ,
D02086 ,
D08127 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
50 Loratadine
(Synonym: KIRKLAND SIGNATURE ALLERCLEAR D 24 HR Extended Release)		[2] Loratadina; Loratadine[1] D00364 [1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[4] 13, 46, 89, 98
51 Magnesium
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		[1] Magnesium---[21] 3, 6, 11, 13, 15, 46, 51, 64, 70, 93, 97, 111, 166, 225, 235, 256, 284, 291, 296, 297, 298
52 Magnesium gluconate
(Synonym: Swiss One Timed Release Tab)		[2] Magnesium; Magnesium gluconate[1] D04835 --[2] 296, 297
53 Manganese citrate
(Synonym: Release)		[1] Release---[12] 6, 8, 13, 46, 65, 78, 81, 96, 97, 206, 226, 299
54 Melatonin
(Synonym: Melatonin Rapid Release Gelcaps 5 mg)		[2] Circadin; Melatonin[1] D08170 [2] MTNR1A,
MTNR1B 💬		[2] Circadian entrainment, Neuroactive ligand-receptor interaction 💬[12] 6, 8, 13, 37, 46, 49, 90, 97, 144, 145, 149, 202
55 Memantine
(Synonym: Memantine and Donepezil Hydrochlorides Extended-release)		[3] Ebixa; Memantine; MEMANTINE HYDROCHLORIDE[2] D04905 ,
D08174 		[5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[7] 2, 6, 8, 13, 49, 127, 205
56 Mesalazine
(Synonym: Pentasa Extended-release Tablets 250mg)		[10] 5-Aminosalicylic acid; 5-ASA; ASACOL; Mesalamine; MESALAZINA; MESALAZINE; Mesalazinum; MEZAVANT; Pentasa; Salofalk[1] D00377 --[4] 46, 96, 97, 164
57 Metformin
(Synonym: Metformin Hydrochloride Extended-Release)		[5] Metformin; Metformin HCl; Metformin hydrochloride; Metformina; Metformine[2] D00944 (Name: METFORMIN HYDROCHLORIDE EXTENDED RELEASE),
D04966 		[2] PRKAA1,
PRKAA2 💬		[20] AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬[24] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
58 Methylphenidate
(Synonym: JORNAY PM Extended-Release)		[3] Methylphenidate; METHYLPHENIDATE HYDROCHLORIDE; Ritalin[2] D01296 (Name: METHYLPHENIDATE HYDROCHLORIDE EXTENDED RELEASE),
D04999 		[2] SLC6A2,
SLC6A3 💬		[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬[7] 6, 13, 34, 84, 113, 179, 206
59 Metoprolol
(Synonym: Metoprolol Succinate Extended-release)		[2] Metoprolol; METOPROLOL SUCCINATE[3] D00601 ,
D02358 ,
D05011 		[1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 17, 57, 58, 113, 193, 226
60 Minocycline
(Synonym: Minolira Extended Release)		[3] Minocycline; MINOCYCLINE HYDROCHLORIDE; Minomycin[2] D00850 (Name: MINOLIRA EXTENDED RELEASE),
D05045 		--[14] 2, 6, 8, 13, 46, 84, 85, 90, 94, 162, 201, 206, 280, 299
61 Misoprostol
(Synonym: Diclofenac Sodium and Misoprostol Delayed-Release)		[1] Misoprostol[1] D00419 [3] PTGER2,
PTGER3,
PTGER4 💬		[9] Calcium signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways in cancer, Regulation of lipolysis in adipocytes, Renin secretion, cAMP signaling pathway 💬[3] 46, 70, 271
62 Morphine
(Synonym: Morphine Sulfate Extended Release)		[2] Morphine; Morphine Sulfate[3] D00842 ,
D02271 ,
D08233 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[6] 36, 46, 70, 85, 86, 298
63 Naltrexone
(Synonym: Naltrexone Hydrochloride and Bupropion Hydrochloride Extended-Release)		[2] Naltrexone; Naltrexone Hydrochloride[2] D02095 ,
D05113 		[3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
64 Naproxen
(Synonym: Naproxen delayed release)		[5] Naprosyn; Naproxen; Naproxen oral suspension; NAPROXEN SODIUM; Propanoic acid[1] D00118 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[4] 13, 46, 107, 271
65 Nevirapine
(Synonym: Nevirapine Extended Release)		[1] Nevirapine[1] D00435 --[1] 265
66 Niacin
(Synonym: Timed Release Vita-vim Srt)		[2] Niacin; Nicotinic acid[1] D00049 --[4] 6, 78, 79, 265
67 Nicotinamide
(Synonym: B Plus C 300mg Timed Release)		[4] Ginseng; Multivitamin; Niacinamide; Nicotinamide[1] D00036 --[11] 2, 5, 6, 13, 18, 49, 65, 67, 107, 162, 191
68 Nifedipine
(Synonym: Nifedipine Extended Release)		[1] Nifedipine[1] D00437 [4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 50, 81
69 Omeprazole
(Synonym: Omeprazole Delayed-Release)		[5] Losec; Omeprazol; Omeprazole; Omeprazole 20 mg; OMEPRAZOLE MAGNESIUM[4] D00455 ,
D01207 ,
D05259 ,
D05261 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
70 Oxybutynin
(Synonym: Oxybutynin ChlorideExtended Release Extended Release)		[1] Oxybutynin[2] D00465 ,
D00722 		[5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[3] 6, 13, 53
71 Oxycodone
(Synonym: Oxycodone Hydrochloride Controlled-release)		[3] Oxycodone; OXYCODONE HYDROCHLORIDE; Oxycodone/Acetaminophen[3] D03783 ,
D05312 ,
D05462 		[3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[7] 6, 13, 46, 70, 226, 231, 298
72 Oxymorphone
(Synonym: Oxymorphone Hydrochloride Extended-Release)		[1] Opana[1] D08323 [1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[1] 70
73 Pantoprazole
(Synonym: Pantoprazole Sodium Delayed Release)		[1] Pantoprazole[2] D02593 ,
D05353 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[2] 13, 65
74 Paroxetine
(Synonym: PAROXETINE HYDROCHLORIDE Controlled-Release)		[1] Paroxetine[4] D02260 ,
D02362 ,
D05374 ,
D05375 		[1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[4] 6, 13, 46, 85
75 Phenylephrine
(Synonym: Tylenol Cold Rapid Release)		[1] Phenylephrine[2] D00511 ,
D08365 		[3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 22
76 Potassium
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		[1] Potassium[1] D08403 --[12] 36, 46, 66, 67, 88, 94, 98, 115, 167, 179, 215, 235
77 Pramipexole
(Synonym: Pramipexole Dihydrochloride Extended-Release)		[7] Mirapex; Mirapex ER; Mirapexin; Pramipexol; Pramipexole; PRAMIPEXOLE DIHYDROCHLORIDE; SIFROL[2] D00559 ,
D05575 		[3] DRD2,
DRD3,
DRD4 💬		[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[3] 2, 6, 20
78 Pregabalin
(Synonym: Pregabalin Extended Release)		[2] Lyrica; Pregabalin[1] D02716 (Name: PREGABALIN EXTENDED RELEASE)[4] CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4 💬		[7] Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway 💬[5] 13, 36, 46, 70, 298
79 Pseudoephedrine
(Synonym: KIRKLAND SIGNATURE ALLERCLEAR D 24 HR Extended Release)		[1] Pseudoephedrine[4] D00485 ,
D05648 ,
D05649 ,
D08449 		[9] ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬		[14] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 17
80 Pyridoxine
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		[2] Pyridoxine; Vitamin B6[2] D02179 ,
D08454 		--[5] 6, 93, 145, 206, 320
81 Quetiapine
(Synonym: Quetiapine Extended-Release)		[2] Quetiapine; Seroquel[2] D00458 ,
D08456 		[2] DRD2,
HTR2A 💬		[11] Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬[2] 6, 13
82 Rabeprazole
(Synonym: Rabeprazole Sodium Delayed-release)		[1] Rabeprazole[2] D00724 (Name: RABEPRAZOLE SODIUM DELAYED-RELEASE),
D08463 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[2] 2, 51
83 Ranitidine
(Synonym: Ranitidine Immediate release)		[1] Ranitidine[2] D00422 ,
D00673 		[1] HRH2 💬[3] Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction 💬[2] 13, 65
84 Riboflavin
(Synonym: Timed Release Vita-vim Srt)		[2] RIBOFLAVIN; Vitamin B2[3] D00050 ,
D01622 ,
D01913 		--[8] 13, 38, 46, 96, 97, 162, 168, 265
85 Salicylic acid
(Synonym: Smart Release Mandelic 11 PERCENT)		[2] 2-Hydroxybenzoic acid; Salicylic acid[1] D00097 --[1] 97
86 Selenium
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		[1] Selenium---[4] 13, 96, 278, 298
87 Sodium fluoride
(Synonym: Flor-Opal Sustained-Release Fluoride)		[2] Beam; Sodium fluoride[1] D00943 --[1] 51
88 Somatostatin
(Synonym: Synthetic growth hormone release-inhibiting hormone)		[1] Somatostatin[1] D07431 [5] SSTR1,
SSTR2,
SSTR3,
SSTR4,
SSTR5 💬		[4] Gastric acid secretion, Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[2] 67, 78
89 Sulfasalazine
(Synonym: Sulfasalazine Delayed-Release)		[3] Salazosulfapyridine; Salicylazosulfapyridine; SULFASALAZINE[1] D00448 --[6] 46, 86, 94, 107, 270, 271
90 Theophylline
(Synonym: Theophylline Extended Release)		[1] Theophylline[5] D00371 ,
D01712 ,
D02017 ,
D06103 ,
D06104 		[19] ADORA1,
ADORA2A,
ADORA2B,
PDE10A,
PDE11A,
PDE1A,
PDE1B,
PDE1C,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE7A,
PDE7B,
PDE8A,
PDE8B 💬		[24] Alcoholism, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Cortisol synthesis and secretion, Cushing syndrome, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Parkinson disease, Progesterone-mediated oocyte maturation, Purine metabolism, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Taste transduction, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 236, 299
91 Thiamine
(Synonym: Vitamin B Complex Plus C 300mg Timed Release)		[2] Thiamine; Vitamin B1[1] D08580 --[5] 8, 13, 93, 145, 265
92 Tolterodine
(Synonym: Ach-tolterodine Tartrate Extended Release)		[1] Tolterodine[2] D00646 ,
D01148 (Name: TOLTERODINE TARTRATE EXTENDED RELEASE)		[1] CHRM3 💬[11] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬[2] 17, 53
93 Tramadol
(Synonym: Tramadol Hydrochloride Extended Release)		[2] Tramadol; Ultracet[2] D01355 ,
D08623 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[5] 46, 70, 78, 226, 271
94 Valproic acid
(Synonym: Divalproex Sodium Delayed Release)		[3] Valproate; VALPROATE SODIUM; Valproic acid[1] D00399 [7] ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		[17] Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬[17] 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
95 Venlafaxine
(Synonym: Venlafaxine Hydrochloride Extended-release Capsules)		[2] Venlafaxine; VENLAFAXINE HYDROCHLORIDE[2] D00821 ,
D08670 		[2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[3] 6, 13, 46
96 Vitamin A
(Synonym: Swiss One Timed Release Tab)		[1] Vitamin A[2] D00069 ,
D06543 		[2] RARA,
RARB 💬		[8] Acute myeloid leukemia, Estrogen signaling pathway, Gastric cancer, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[3] 13, 53, 90
97 Vitamin D
(Synonym: Swiss One Timed Release Tab)		[3] Calciferol; Cod liver oil; Vitamin D---[24] 3, 13, 15, 19, 41, 43, 44, 46, 49, 50, 68, 93, 95, 96, 97, 98, 179, 222, 228, 235, 256, 274, 298, 299
98 Vitamin E
(Synonym: Swiss One Timed Release Tab)		[2] Alpha-tocopherol; Vitamin E[1] D02331 --[12] 2, 6, 13, 20, 46, 49, 90, 96, 97, 206, 299, 317
99 Zinc
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		[3] Nicotinamide; Wilzin; Zinc---[4] 2, 113, 171, 299
100 Zinc gluconate
(Synonym: Swiss One Timed Release Tab)		[1] ZINC GLUCONATE[1] D02390 --[1] 171
101 Zolpidem
(Synonym: Zolpidem Tartrate Extended-Release)		[2] Zolpidem; Zolpidem Tartrate[2] D00706 ,
D08690 		[16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[3] 5, 6, 46