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Disease
Drug
Target Gene/Pathway
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Drug
Description in Trials
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Showing 1 to 10 of 31 drugs
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No.
KEGG DRUG
DrugBank
薬物名(臨床試験情報から抽出)
KEGG GENES
KEGG PATHWAY
指定難病告示番号
1
Leucine
1件:
Leucine
Leucine
2件:
L-leucine
L-leucine
;
Leucine
;
-
-
6件:
6
6
,
19
,
65
,
283
,
284
,
299
2
Tacrolimus
1件:
Tacrolimus
Tacrolimus
2件:
Prograf
Prograf
;
Tacrolimus
;
5件:
PPP3CA
PPP3CA
,
PPP3CB
,
PPP3CC
,
PPP3R1
,
PPP3R2
💬
33件:
Alzheimer disease
Alzheimer disease
,
Amphetamine addiction
,
Amyotrophic lateral sclerosis
,
Axon guidance
,
B cell receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
Calcium signaling pathway
,
Cellular senescence
,
Dopaminergic synapse
,
Glucagon signaling pathway
,
Glutamatergic synapse
,
Human T-cell leukemia virus 1 infection
,
Human cytomegalovirus infection
,
Human immunodeficiency virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Lipid and atherosclerosis
,
Long-term potentiation
,
MAPK signaling pathway
,
Natural killer cell mediated cytotoxicity
,
Oocyte meiosis
,
Osteoclast differentiation
,
Oxytocin signaling pathway
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Pathways of neurodegeneration - multiple diseases
,
Prion disease
,
Renin secretion
,
T cell receptor signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Tuberculosis
,
VEGF signaling pathway
,
Wnt signaling pathway
,
cGMP-PKG signaling pathway
💬
33件:
Alzheimer disease
,
Amphetamine addiction
,
Amyotrophic lateral sclerosis
,
Axon guidance
,
B cell
...
34件:
2
2
,
6
,
11
,
13
,
36
,
46
,
49
,
50
,
51
,
53
,
56
,
60
,
61
,
62
,
65
,
66
,
85
,
95
,
96
,
97
,
113
,
151
,
158
,
164
,
222
,
224
,
226
,
227
,
228
,
283
,
284
,
285
,
286
,
299
34件:
2
,
6
,
11
,
13
,
36
,
46
,
49
,
50
,
51
,
53
,
56
,
60
,
61
,
62
,
65
,
66
,
85
,
95
,
96
,
97
,
113
,
151
,
158
,
16
...
3
Methotrexate
1件:
Methotrexate
Methotrexate
6件:
Methotrexat
Methotrexat
;
METHOTREXATE
;
METHOTREXATE SODIUM
;
Metoject
;
Metotrexato
;
Méthotrexate
;
2件:
DHFR
DHFR
,
DHFR2
💬
5件:
Antifolate resistance
Antifolate resistance
,
Biosynthesis of cofactors
,
Folate biosynthesis
,
Metabolic pathways
,
One carbon pool by folate
💬
5件:
Antifolate resistance
,
Biosynthesis of cofactors
,
Folate biosynthesis
,
Metabolic pathways
,
One c
...
38件:
11
11
,
13
,
19
,
34
,
35
,
40
,
41
,
42
,
43
,
44
,
45
,
46
,
49
,
50
,
51
,
53
,
55
,
56
,
60
,
62
,
65
,
84
,
93
,
96
,
97
,
107
,
162
,
164
,
172
,
256
,
270
,
271
,
283
,
284
,
285
,
286
,
326
,
331
38件:
11
,
13
,
19
,
34
,
35
,
40
,
41
,
42
,
43
,
44
,
45
,
46
,
49
,
50
,
51
,
53
,
55
,
56
,
60
,
62
,
65
,
84
,
93
,
96
, ...
4
Cyclosporine
1件:
Cyclosporine
Cyclosporine
10件:
CICLOSPORIN
CICLOSPORIN
;
Ciclosporina
;
Ciclosporine
;
Cyclosporin
;
Cyclosporin A
;
Cyclosporine
;
Cyclosporine A
;
Ikervis
;
NEORAL
;
Restasis
;
10件:
CICLOSPORIN
;
Ciclosporina
;
Ciclosporine
;
Cyclosporin
;
Cyclosporin A
;
Cyclosporine
;
Cyclosporine
...
5件:
PPP3CA
PPP3CA
,
PPP3CB
,
PPP3CC
,
PPP3R1
,
PPP3R2
💬
33件:
Alzheimer disease
Alzheimer disease
,
Amphetamine addiction
,
Amyotrophic lateral sclerosis
,
Axon guidance
,
B cell receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
Calcium signaling pathway
,
Cellular senescence
,
Dopaminergic synapse
,
Glucagon signaling pathway
,
Glutamatergic synapse
,
Human T-cell leukemia virus 1 infection
,
Human cytomegalovirus infection
,
Human immunodeficiency virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Lipid and atherosclerosis
,
Long-term potentiation
,
MAPK signaling pathway
,
Natural killer cell mediated cytotoxicity
,
Oocyte meiosis
,
Osteoclast differentiation
,
Oxytocin signaling pathway
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Pathways of neurodegeneration - multiple diseases
,
Prion disease
,
Renin secretion
,
T cell receptor signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Tuberculosis
,
VEGF signaling pathway
,
Wnt signaling pathway
,
cGMP-PKG signaling pathway
💬
33件:
Alzheimer disease
,
Amphetamine addiction
,
Amyotrophic lateral sclerosis
,
Axon guidance
,
B cell
...
44件:
11
11
,
19
,
20
,
26
,
28
,
36
,
38
,
39
,
40
,
41
,
42
,
45
,
46
,
49
,
50
,
53
,
55
,
56
,
58
,
60
,
61
,
62
,
63
,
64
,
65
,
90
,
93
,
95
,
97
,
107
,
113
,
162
,
164
,
222
,
226
,
228
,
234
,
269
,
274
,
283
,
284
,
285
,
302
,
326
44件:
11
,
19
,
20
,
26
,
28
,
36
,
38
,
39
,
40
,
41
,
42
,
45
,
46
,
49
,
50
,
53
,
55
,
56
,
58
,
60
,
61
,
62
,
63
,
64
, ...
5
Busulfan
1件:
Busulfan
Busulfan
3件:
Busilvex
Busilvex
;
Busulfan
;
BUSULFANO
;
-
-
13件:
19
19
,
20
,
28
,
36
,
49
,
51
,
60
,
65
,
164
,
274
,
284
,
285
,
326
6
Cyclophosphamide
1件:
Cyclophosphamide
Cyclophosphamide
6件:
Ciclofosfamida
Ciclofosfamida
;
Ciclofosfamide
;
Cyclophosphamid
;
CYCLOPHOSPHAMIDE
;
Cyclophosphamidum
;
Cytoxan
;
-
-
44件:
11
11
,
13
,
14
,
16
,
19
,
20
,
26
,
28
,
35
,
36
,
40
,
41
,
42
,
43
,
44
,
45
,
46
,
49
,
50
,
51
,
52
,
56
,
60
,
62
,
65
,
66
,
84
,
85
,
93
,
96
,
162
,
164
,
172
,
205
,
222
,
224
,
256
,
274
,
283
,
284
,
285
,
288
,
326
,
331
44件:
11
,
13
,
14
,
16
,
19
,
20
,
26
,
28
,
35
,
36
,
40
,
41
,
42
,
43
,
44
,
45
,
46
,
49
,
50
,
51
,
52
,
56
,
60
,
62
, ...
7
Hydroxyurea
1件:
Hydroxyurea
Hydroxyurea
1件:
Hydroxyurea
Hydroxyurea
;
1件:
RRM2
RRM2
💬
7件:
Drug metabolism - other enzymes
Drug metabolism - other enzymes
,
Glutathione metabolism
,
Metabolic pathways
,
Nucleotide metabolism
,
Purine metabolism
,
Pyrimidine metabolism
,
p53 signaling pathway
💬
7件:
Drug metabolism - other enzymes
,
Glutathione metabolism
,
Metabolic pathways
,
Nucleotide metaboli
...
8件:
3
3
,
13
,
19
,
20
,
65
,
85
,
86
,
284
8
Melphalan
1件:
Melphalan
Melphalan
3件:
ALKERAN
ALKERAN
;
Melphalan
;
Melphalan Hydrochloride
;
-
-
15件:
11
11
,
13
,
14
,
19
,
20
,
28
,
60
,
62
,
65
,
96
,
164
,
234
,
284
,
285
,
299
9
Methylprednisolone
1件:
Methylprednisolone
Methylprednisolone
4件:
Medrol
Medrol
;
Methylprednisolon
;
Methylprednisolone
;
METHYLPREDNISOLONE ACETATE
;
1件:
NR3C1
NR3C1
💬
1件:
Neuroactive ligand-receptor interaction
Neuroactive ligand-receptor interaction
💬
46件:
2
2
,
11
,
13
,
14
,
18
,
19
,
25
,
26
,
35
,
38
,
39
,
40
,
41
,
42
,
43
,
45
,
46
,
49
,
50
,
51
,
60
,
62
,
63
,
64
,
65
,
66
,
83
,
84
,
85
,
86
,
93
,
95
,
96
,
97
,
145
,
162
,
164
,
211
,
220
,
222
,
224
,
271
,
283
,
284
,
285
,
296
46件:
2
,
11
,
13
,
14
,
18
,
19
,
25
,
26
,
35
,
38
,
39
,
40
,
41
,
42
,
43
,
45
,
46
,
49
,
50
,
51
,
60
,
62
,
63
,
64
, ...
10
Prednisone
1件:
Prednisone
Prednisone
3件:
Prednisona
Prednisona
;
PREDNISONE
;
RAYOS
;
1件:
NR3C1
NR3C1
💬
1件:
Neuroactive ligand-receptor interaction
Neuroactive ligand-receptor interaction
💬
45件:
2
2
,
11
,
13
,
14
,
19
,
26
,
35
,
40
,
41
,
42
,
43
,
44
,
45
,
46
,
49
,
50
,
51
,
53
,
61
,
63
,
64
,
65
,
66
,
79
,
81
,
84
,
85
,
86
,
95
,
96
,
97
,
113
,
162
,
164
,
205
,
222
,
224
,
228
,
283
,
284
,
288
,
299
,
300
,
307
,
331
45件:
2
,
11
,
13
,
14
,
19
,
26
,
35
,
40
,
41
,
42
,
43
,
44
,
45
,
46
,
49
,
50
,
51
,
53
,
61
,
63
,
64
,
65
,
66
,
79
, ...