Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 D02910 💬 Amiodarone 2件: 28, 127 💬
2 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 D00235 💬 Atenolol 1件: 167 💬
3 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 D02342 💬 Bisoprolol 4件: 58, 67, 86, 113 💬
4 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 D07660 💬 Celiprolol 1件: 168 💬
5 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 D03879 💬 Dobutamine 4件: 57, 58, 86, 215 💬
6 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 D07916 💬 Esmolol 1件: 58 💬
7 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 D02358 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
8 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 D05127 💬 Nebivolol 4件: 17, 85, 113, 167 💬
9 Chemical carcinogenesis - receptor activation 💬
2件: ADRB1, ADRB2 💬 D00255 💬 Carvedilol 4件: 57, 86, 113, 210 💬
10 Chemical carcinogenesis - receptor activation 💬
2件: ADRB1, ADRB2 💬 D00432 💬 Nadolol 1件:  6  💬
11 Chemical carcinogenesis - receptor activation 💬
2件: ADRB1, ADRB2 💬 D00378 💬 Timolol 2件: 157, 227 💬
12 Chemical carcinogenesis - receptor activation 💬
2件: ADRB1, ADRB2 💬 D08600 💬 Timolol 2件: 157, 227 💬
13 Chemical carcinogenesis - receptor activation 💬
3件: ADRB1, ADRB2, ADRB3 💬 D02349 💬 Dipivefrin 1件:  6  💬
14 Chemical carcinogenesis - receptor activation 💬
3件: ADRB1, ADRB2, ADRB3 💬 D01277 💬 Droxidopa 5件:  5 ,  6 , 17, 169, 170 💬
15 Chemical carcinogenesis - receptor activation 💬
3件: ADRB1, ADRB2, ADRB3 💬 D00124 💬 Ephedrine 1件: 11 💬
16 Chemical carcinogenesis - receptor activation 💬
3件: ADRB1, ADRB2, ADRB3 💬 D00095 💬 Epinephrine 3件: 46, 70, 96 💬
17 Chemical carcinogenesis - receptor activation 💬
3件: ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine 2件: 22, 296 💬
18 Chemical carcinogenesis - receptor activation 💬
3件: ADRB1, ADRB2, ADRB3 💬 D08443 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬
19 Chemical carcinogenesis - receptor activation 💬
3件: ADRB1, ADRB2, ADRB3 💬 D08449 💬 Pseudoephedrine 1件: 17 💬
20 Chemical carcinogenesis - receptor activation 💬
1件: ADRB2 💬 D07713 💬 Clenbuterol 5件:  1 ,  2 ,  6 , 13, 256 💬
21 Chemical carcinogenesis - receptor activation 💬
1件: ADRB2 💬 D07990 💬 Formoterol 3件: 85, 228, 299 💬
22 Chemical carcinogenesis - receptor activation 💬
1件: ADRB2 💬 D08092 💬 Isoxsuprine 1件: 13 💬
23 Chemical carcinogenesis - receptor activation 💬
1件: ADRB2 💬 D08124 💬 Levosalbutamol 1件: 49 💬
24 Chemical carcinogenesis - receptor activation 💬
1件: ADRB2 💬 D02147 💬 Salbutamol 12件:  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬
25 Chemical carcinogenesis - receptor activation 💬
1件: ADRB2 💬 D05792 💬 Salmeterol 1件: 299 💬
26 Chemical carcinogenesis - receptor activation 💬
1件: ADRB2 💬 D08570 💬 Terbutaline 1件: 118 💬
27 Chemical carcinogenesis - receptor activation 💬
1件: ADRB2 💬 D02151 💬 Tulobuterol 1件:  6  💬
28 Chemical carcinogenesis - receptor activation 💬
1件: ADRB3 💬 D09535 💬 Mirabegron 4件:  6 , 13, 53, 226 💬
29 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 D03338 💬 Calusterone 1件:  2  💬
30 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 D00586 💬 Flutamide 1件: 81 💬
31 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 D08250 💬 Nandrolone 2件: 60, 85 💬
32 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 D00955 💬 Nandrolone decanoate 2件: 60, 85 💬
33 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 D00462 💬 Oxandrolone 2件: 211, 285 💬
34 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 D00444 💬 Stanozolol 1件: 60 💬
35 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 D00075 💬 Testosterone 8件:  1 ,  2 ,  3 , 13, 60, 76, 78, 113 💬
36 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 D08573 💬 Testosterone decanoate 1件: 113 💬
37 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 D00958 💬 Testosterone enanthate 1件: 113 💬
38 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 D08574 💬 Testosterone phenylpropionate 1件: 113 💬
39 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 D00959 💬 Testosterone propionate 1件: 113 💬
40 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 D06087 💬 Testosterone undecanoate 2件: 13, 60 💬
41 Chemical carcinogenesis - receptor activation 💬
3件: AR, ESR1, ESR2 💬 D08409 💬 Prasterone 6件: 49, 53, 83, 86, 96, 113 💬
42 Chemical carcinogenesis - receptor activation 💬
3件: AR, ESR1, PGR 💬 D00289 💬 Danazol 5件: 60, 63, 64, 65, 285 💬
43 Chemical carcinogenesis - receptor activation 💬
1件: BCL2 💬 D10679 💬 Venetoclax 1件: 28 💬
44 Chemical carcinogenesis - receptor activation 💬
5件: CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine 1件: 67 💬
45 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine 4件: 13, 51, 67, 298 💬
46 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem 3件: 51, 58, 86 💬
47 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine 1件:  6  💬
48 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine 2件: 70, 86 💬
49 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine 2件: 50, 81 💬
50 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine 1件: 90 💬
51 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline 2件: 58, 272 💬
52 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08441 💬 Propiverine 1件: 226 💬
53 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 6件:  6 , 97, 140, 144, 156, 193 💬
54 Chemical carcinogenesis - receptor activation 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil 4件: 58, 96, 140, 167 💬
55 Chemical carcinogenesis - receptor activation 💬
6件: CHRNA3, CHRNA4, CHRNA7, CHRNA9, CHRNB2, CHRNB4 💬 D03365 💬 Nicotine 3件:  6 , 13, 84 💬
56 Chemical carcinogenesis - receptor activation 💬
2件: CHRNA4, CHRNB2 💬 D08669 💬 Varenicline 3件:  6 , 18, 53 💬
57 Chemical carcinogenesis - receptor activation 💬
1件: EGFR 💬 D03455 💬 Cetuximab 2件: 51, 86 💬
58 Chemical carcinogenesis - receptor activation 💬
1件: EGFR 💬 D07907 💬 Erlotinib 1件: 94 💬
59 Chemical carcinogenesis - receptor activation 💬
1件: EGFR 💬 D01977 💬 Gefitinib 1件: 75 💬
60 Chemical carcinogenesis - receptor activation 💬
1件: EGFR 💬 D11251 💬 Icotinib 1件: 34 💬
61 Chemical carcinogenesis - receptor activation 💬
1件: EGFR 💬 D08108 💬 Lapatinib 3件: 34, 74, 75 💬
62 Chemical carcinogenesis - receptor activation 💬
1件: EGFR 💬 D08950 💬 Neratinib 1件: 34 💬
63 Chemical carcinogenesis - receptor activation 💬
1件: EGFR 💬 D11772 💬 Tesevatinib 1件: 67 💬
64 Chemical carcinogenesis - receptor activation 💬
1件: ESR1 💬 D00554 💬 Ethinylestradiol 4件: 13, 46, 49, 299 💬
65 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 D07726 💬 Clomifene 1件: 74 💬
66 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 D11513 💬 Estetrol 1件: 53 💬
67 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 D11514 💬 Estetrol 1件: 53 💬
68 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 D00105 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
69 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 D01413 💬 Estradiol valerate 1件: 65 💬
70 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 D00185 💬 Estriol 2件: 13, 227 💬
71 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 D01986 💬 Estriol 2件: 13, 227 💬
72 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 D01161 💬 Fulvestrant 2件: 49, 86 💬
73 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 D00575 💬 Mestranol 2件: 46, 49 💬
74 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 D08465 💬 Raloxifene 1件: 46 💬
75 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 D08559 💬 Tamoxifen 3件:  2 , 113, 227 💬
76 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, PGR 💬 D02367 💬 Desogestrel 1件: 230 💬
77 Chemical carcinogenesis - receptor activation 💬
1件: JAK2 💬 D10308 💬 Baricitinib 13件:  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
78 Chemical carcinogenesis - receptor activation 💬
1件: JAK2 💬 D10653 💬 Peficitinib 1件: 46 💬
79 Chemical carcinogenesis - receptor activation 💬
1件: JAK2 💬 D09959 💬 Ruxolitinib 3件: 60, 65, 228 💬
80 Chemical carcinogenesis - receptor activation 💬
1件: JAK2 💬 D09970 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
81 Chemical carcinogenesis - receptor activation 💬
2件: MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib 1件: 34 💬
82 Chemical carcinogenesis - receptor activation 💬
2件: MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib 1件: 280 💬
83 Chemical carcinogenesis - receptor activation 💬
2件: MAP2K1, MAP2K2 💬 D11675 💬 Mirdametinib 1件: 34 💬
84 Chemical carcinogenesis - receptor activation 💬
2件: MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib 1件: 34 💬
85 Chemical carcinogenesis - receptor activation 💬
2件: MAP2K1, MAP2K2 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
86 Chemical carcinogenesis - receptor activation 💬
1件: MTOR 💬 D02714 💬 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
87 Chemical carcinogenesis - receptor activation 💬
1件: MTOR 💬 D00753 💬 Sirolimus 40件:  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
88 Chemical carcinogenesis - receptor activation 💬
1件: MTOR 💬 D06068 💬 Temsirolimus 1件: 13 💬
89 Chemical carcinogenesis - receptor activation 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 5件: 46, 51, 53, 271, 300 💬
90 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 D01217 💬 Dydrogesterone 1件: 13 💬
91 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 D00950 💬 Levonorgestrel 1件: 13 💬
92 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 D00951 💬 Medroxyprogesterone acetate 8件: 13, 35, 46, 49, 50, 51, 60, 107 💬
93 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 D00952 💬 Megestrol acetate 1件: 76 💬
94 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 D00585 💬 Mifepristone 1件: 75 💬
95 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 D07222 💬 Nomegestrol 1件: 13 💬
96 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 D08281 💬 Nomegestrol acetate 1件: 13 💬
97 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 D00182 💬 Norethisterone 4件: 13, 46, 49, 299 💬
98 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 D05209 💬 Norgestimate 1件: 299 💬
99 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 D00066 💬 Progesterone 2件: 76, 299 💬
100 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 D09567 💬 Ulipristal 1件: 10 💬
101 Chemical carcinogenesis - receptor activation 💬
1件: PIK3CA 💬 D11011 💬 Alpelisib 1件: 138 💬
102 Chemical carcinogenesis - receptor activation 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
103 Chemical carcinogenesis - receptor activation 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
104 Chemical carcinogenesis - receptor activation 💬
1件: PPARA 💬 D01366 💬 Bezafibrate 7件: 20, 93, 94, 160, 296, 316, 324 💬
105 Chemical carcinogenesis - receptor activation 💬
1件: PPARA 💬 D11208 💬 Elafibranor 2件: 93, 94 💬
106 Chemical carcinogenesis - receptor activation 💬
1件: PPARA 💬 D00565 💬 Fenofibrate 6件:  8 , 79, 93, 94, 97, 265 💬
107 Chemical carcinogenesis - receptor activation 💬
1件: PPARA 💬 D10711 💬 Pemafibrate 1件: 93 💬
108 Chemical carcinogenesis - receptor activation 💬
1件: PRKCB 💬 D11935 💬 Enzastaurin 1件: 168 💬
109 Chemical carcinogenesis - receptor activation 💬
1件: RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
110 Chemical carcinogenesis - receptor activation 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
111 Chemical carcinogenesis - receptor activation 💬
3件: RXRA, RXRB, RXRG 💬 D02754 💬 Acitretin 1件: 37 💬
112 Chemical carcinogenesis - receptor activation 💬
3件: RXRA, RXRB, RXRG 💬 D02815 💬 Alitretinoin 1件: 49 💬
113 Chemical carcinogenesis - receptor activation 💬
3件: RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene 2件: 13, 75 💬
114 Chemical carcinogenesis - receptor activation 💬
1件: SRC 💬 D03252 💬 Bosutinib 2件:  2 , 67 💬
115 Chemical carcinogenesis - receptor activation 💬
1件: SRC 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
116 Chemical carcinogenesis - receptor activation 💬
1件: SRC 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
117 Chemical carcinogenesis - receptor activation 💬
1件: SRC 💬 D09664 💬 Saracatinib 3件:  6 , 89, 272 💬
118 Chemical carcinogenesis - receptor activation 💬
1件: TNFSF11 💬 D03684 💬 Denosumab 8件: 46, 50, 70, 93, 95, 96, 274, 299 💬
119 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 D01518 💬 Alfacalcidol 8件: 41, 46, 49, 50, 96, 107, 235, 238 💬
120 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 D00122 💬 Calcifediol 2件: 113, 299 💬
121 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 D01125 💬 Calcipotriol 2件: 36, 51 💬
122 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 D00129 💬 Calcitriol 9件: 18, 37, 46, 49, 66, 96, 158, 235, 326 💬
123 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 D00188 💬 Cholecalciferol 24件:  6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299 💬
124 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 D00299 💬 Dihydrotachysterol 2件:  6 , 85 💬
125 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 D07578 💬 Eldecalcitol 1件: 46 💬
126 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 D00187 💬 Ergocalciferol 6件: 46, 49, 84, 96, 97, 299 💬
127 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 D00930 💬 Paricalcitol 5件: 19, 66, 218, 238, 298 💬
128 Chemical carcinogenesis - receptor activation 💬
1件: VEGFA 💬 D09574 💬 Aflibercept 2件: 90, 166 💬
129 Chemical carcinogenesis - receptor activation 💬
1件: VEGFA 💬 D06409 💬 Bevacizumab 6件: 13, 34, 85, 87, 227, 280 💬
130 Chemical carcinogenesis - receptor activation 💬
1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬