Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Amyotrophic lateral sclerosis 💬	[1] BCL2 💬	D10679 💬	Venetoclax	[1] 28 💬
2	Amyotrophic lateral sclerosis 💬	[1] CASP9 💬	D11195 💬	Rimiducid	[6] 19, 60, 65, 284, 285, 326 💬
3	Amyotrophic lateral sclerosis 💬	[1] ERBB4 💬	D08950 💬	Neratinib	[1] 34 💬
4	Amyotrophic lateral sclerosis 💬	[2] GRIA1, GRIA2 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
5	Amyotrophic lateral sclerosis 💬	[2] GRIA1, GRIA2 💬	D02696 💬	Talampanel	[2] 2 , 6 💬
6	Amyotrophic lateral sclerosis 💬	[2] GRIA1, GRIA2 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
7	Amyotrophic lateral sclerosis 💬	[7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D00775 💬	Riluzole	[9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬
8	Amyotrophic lateral sclerosis 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D07058 💬	Acamprosate	[2] 6 , 206 💬
9	Amyotrophic lateral sclerosis 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D07441 💬	Amantadine	[4] 6 , 8 , 13, 127 💬
10	Amyotrophic lateral sclerosis 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D07283 💬	Esketamine	[3] 2 , 4 , 70 💬

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