Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 ABC transporters 💬
 [1] ABCC8 💬 D00418 💬 Minoxidil [1] 179 💬
2 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
3 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
4 Alcoholism 💬
 [1] DRD2 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
5 Alcoholism 💬
 [1] SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
6 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
7 Amphetamine addiction 💬
 [1] SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
8 Apelin signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
9 Calcium signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
10 Calcium signaling pathway 💬
 [1] HTR2A 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
11 cAMP signaling pathway 💬
 [1] DRD2 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
12 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
13 Cocaine addiction 💬
 [1] DRD2 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
14 Cocaine addiction 💬
 [1] SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
15 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
16 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
17 Cushing syndrome 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
18 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
19 Dopaminergic synapse 💬
 [1] DRD2 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
20 Dopaminergic synapse 💬
 [1] SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
21 Gap junction 💬
 [2] DRD2, HTR2A 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
22 GnRH secretion 💬
 [1] KCNJ11 💬 D00418 💬 Minoxidil [1] 179 💬
23 Inflammatory mediator regulation of TRP channels 💬
 [1] HTR2A 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
24 Insulin secretion 💬
 [2] ABCC8, KCNJ11 💬 D00418 💬 Minoxidil [1] 179 💬
25 Neuroactive ligand-receptor interaction 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
26 Neuroactive ligand-receptor interaction 💬
 [2] DRD2, HTR2A 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
27 Parkinson disease 💬
 [1] DRD2 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
28 Parkinson disease 💬
 [1] SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
29 Pathways in cancer 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
30 Pathways of neurodegeneration - multiple diseases 💬
 [1] SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
31 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
32 Rap1 signaling pathway 💬
 [1] DRD2 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
33 Renin secretion 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
34 Renin-angiotensin system 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
35 Serotonergic synapse 💬
 [1] HTR2A 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
36 Serotonergic synapse 💬
 [1] SLC6A4 💬 D00326 💬 Fluoxetine [6] 13, 17, 78, 86, 179, 206 💬
37 Synaptic vesicle cycle 💬
 [2] SLC6A2, SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
38 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 D00326 💬 Fluoxetine [6] 13, 17, 78, 86, 179, 206 💬
39 Type II diabetes mellitus 💬
 [2] ABCC8, KCNJ11 💬 D00418 💬 Minoxidil [1] 179 💬
40 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬

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