Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Breast cancer 💬	[2] ESR1, ESR2 💬	D00105 💬	Estradiol	[7] 13, 46, 49, 65, 76, 226, 299 💬
2	Breast cancer 💬	[1] PGR 💬	D00952 💬	Megestrol acetate	[1] 76 💬
3	Breast cancer 💬	[1] PGR 💬	D00066 💬	Progesterone	[2] 76, 299 💬
4	Chemical carcinogenesis - receptor activation 💬	[1] AR 💬	D00075 💬	Testosterone	[8] 1 , 2 , 3 , 13, 60, 76, 78, 113 💬
5	Chemical carcinogenesis - receptor activation 💬	[2] ESR1, ESR2 💬	D00105 💬	Estradiol	[7] 13, 46, 49, 65, 76, 226, 299 💬
6	Chemical carcinogenesis - receptor activation 💬	[1] PGR 💬	D00952 💬	Megestrol acetate	[1] 76 💬
7	Chemical carcinogenesis - receptor activation 💬	[1] PGR 💬	D00066 💬	Progesterone	[2] 76, 299 💬
8	Endocrine and other factor-regulated calcium reabsorption 💬	[1] ESR1 💬	D00105 💬	Estradiol	[7] 13, 46, 49, 65, 76, 226, 299 💬
9	Endocrine resistance 💬	[2] ESR1, ESR2 💬	D00105 💬	Estradiol	[7] 13, 46, 49, 65, 76, 226, 299 💬
10	Estrogen signaling pathway 💬	[2] ESR1, ESR2 💬	D00105 💬	Estradiol	[7] 13, 46, 49, 65, 76, 226, 299 💬

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