Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	ESR1	[9] Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone s ...	D00105	Estradiol	[7] 13, 46, 49, 65, 76, 226, 299
2	ESR2	[7] Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, P ...	D00105	Estradiol	[7] 13, 46, 49, 65, 76, 226, 299
3	GNRHR	[2] Neuroactive ligand-receptor interaction, GnRH signaling pathway	D02369	Histrelin	[1] 76
4	GNRHR	[2] Neuroactive ligand-receptor interaction, GnRH signaling pathway	D06247	Triptorelin	[2] 49, 76
5	GNRHR	[2] Neuroactive ligand-receptor interaction, GnRH signaling pathway	D08027	Gonadorelin	[1] 76
6	AR	[4] Oocyte meiosis, Pathways in cancer, Chemical carcinogenesis - receptor activation, Prostate canc ...	D00075	Testosterone	[8] 1, 2, 3, 13, 60, 76, 78, 113
7	PGR	[5] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Chemical ca ...	D00066	Progesterone	[2] 76, 299
8	PGR	[5] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Chemical ca ...	D00952	Megestrol acetate	[1] 76

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