Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Thyroid hormone signaling pathway 💬
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 D00297 💬 Digitoxin [1] 299 💬
2 Thyroid hormone signaling pathway 💬
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 D00298 💬 Digoxin [3]  8 , 46, 210 💬
3 Thyroid hormone signaling pathway 💬
 [1] CASP9 💬 D11195 💬 Rimiducid [6] 19, 60, 65, 284, 285, 326 💬
4 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D07726 💬 Clomifene [1] 74 💬
5 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D00289 💬 Danazol [5] 60, 63, 64, 65, 285 💬
6 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D02367 💬 Desogestrel [1] 230 💬
7 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D11513 💬 Estetrol [1] 53 💬
8 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D11514 💬 Estetrol [1] 53 💬
9 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D00105 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
10 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D01413 💬 Estradiol valerate [1] 65 💬
11 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D00185 💬 Estriol [2] 13, 227 💬
12 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D01986 💬 Estriol [2] 13, 227 💬
13 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D00554 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
14 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D01161 💬 Fulvestrant [2] 49, 86 💬
15 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D00575 💬 Mestranol [2] 46, 49 💬
16 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D08409 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
17 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D08465 💬 Raloxifene [1] 46 💬
18 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D08559 💬 Tamoxifen [3]  2 , 113, 227 💬
19 Thyroid hormone signaling pathway 💬
 [3] HDAC1, HDAC2, HDAC3 💬 D06320 💬 Vorinostat [2] 75, 96 💬
20 Thyroid hormone signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
21 Thyroid hormone signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
22 Thyroid hormone signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D11675 💬 Mirdametinib [1] 34 💬
23 Thyroid hormone signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
24 Thyroid hormone signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
25 Thyroid hormone signaling pathway 💬
 [1] MTOR 💬 D02714 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
26 Thyroid hormone signaling pathway 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
27 Thyroid hormone signaling pathway 💬
 [1] MTOR 💬 D06068 💬 Temsirolimus [1] 13 💬
28 Thyroid hormone signaling pathway 💬
 [1] MYH7 💬 D12265 💬 Mavacamten [1] 58 💬
29 Thyroid hormone signaling pathway 💬
 [1] PIK3CA 💬 D11011 💬 Alpelisib [1] 138 💬
30 Thyroid hormone signaling pathway 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
31 Thyroid hormone signaling pathway 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
32 Thyroid hormone signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
33 Thyroid hormone signaling pathway 💬
 [1] RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
34 Thyroid hormone signaling pathway 💬
 [3] RXRA, RXRB, RXRG 💬 D02754 💬 Acitretin [1] 37 💬
35 Thyroid hormone signaling pathway 💬
 [3] RXRA, RXRB, RXRG 💬 D02815 💬 Alitretinoin [1] 49 💬
36 Thyroid hormone signaling pathway 💬
 [3] RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene [2] 13, 75 💬
37 Thyroid hormone signaling pathway 💬
 [1] SRC 💬 D03252 💬 Bosutinib [2]  2 , 67 💬
38 Thyroid hormone signaling pathway 💬
 [1] SRC 💬 D03658 💬 Dasatinib [2] 51, 85 💬
39 Thyroid hormone signaling pathway 💬
 [1] SRC 💬 D06414 💬 Dasatinib [2] 51, 85 💬
40 Thyroid hormone signaling pathway 💬
 [1] SRC 💬 D09664 💬 Saracatinib [3]  6 , 89, 272 💬
41 Thyroid hormone signaling pathway 💬
 [2] THRA, THRB 💬 D08125 💬 Levothyroxine [5] 19, 49, 78, 80, 222 💬
42 Thyroid hormone signaling pathway 💬
 [2] THRA, THRB 💬 D08128 💬 Liothyronine [4] 13, 78, 210, 212 💬
43 Thyroid hormone signaling pathway 💬
 [2] THRA, THRB 💬 D07214 💬 Tiratricol [2] 78, 139 💬
44 Thyroid hormone signaling pathway 💬
 [1] THRB 💬 D09381 💬 Sobetirome [1] 20 💬