Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	TNF signaling pathway 💬	[4] CCL2, IL1B, IL6, TNF 💬	D01583 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
2	TNF signaling pathway 💬	[1] CSF2 💬	D11343 💬	Otilimab	[1] 46 💬
3	TNF signaling pathway 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
4	TNF signaling pathway 💬	[1] IL1B 💬	D09911 💬	Gevokizumab	[4] 41, 50, 56, 269 💬
5	TNF signaling pathway 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
6	TNF signaling pathway 💬	[1] IL6 💬	D12487 💬	Olokizumab	[2] 46, 96 💬
7	TNF signaling pathway 💬	[1] IL6 💬	D09669 💬	Siltuximab	[2] 28, 331 💬
8	TNF signaling pathway 💬	[1] IL6 💬	D10080 💬	Sirukumab	[2] 41, 46 💬
9	TNF signaling pathway 💬	[2] IL6, TNF 💬	D08976 💬	Pomalidomide	[5] 28, 51, 85, 227, 331 💬
10	TNF signaling pathway 💬	[1] LTA 💬	D10187 💬	Pateclizumab	[1] 46 💬

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