Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Proteoglycans in cancer 💬
 [1] BRAF 💬 D10064 💬 Dabrafenib [1] 34 💬
2 Proteoglycans in cancer 💬
 [3] BRAF, KDR, RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
3 Proteoglycans in cancer 💬
 [1] EGFR 💬 D03455 💬 Cetuximab [2] 51, 86 💬
4 Proteoglycans in cancer 💬
 [1] EGFR 💬 D07907 💬 Erlotinib [1] 94 💬
5 Proteoglycans in cancer 💬
 [1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
6 Proteoglycans in cancer 💬
 [1] EGFR 💬 D11251 💬 Icotinib [1] 34 💬
7 Proteoglycans in cancer 💬
 [2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
8 Proteoglycans in cancer 💬
 [3] EGFR, ERBB2, ERBB4 💬 D08950 💬 Neratinib [1] 34 💬
9 Proteoglycans in cancer 💬
 [3] EGFR, ERBB2, KDR 💬 D11772 💬 Tesevatinib [1] 67 💬
10 Proteoglycans in cancer 💬
 [1] ESR1 💬 D07726 💬 Clomifene [1] 74 💬
11 Proteoglycans in cancer 💬
 [1] ESR1 💬 D00289 💬 Danazol [5] 60, 63, 64, 65, 285 💬
12 Proteoglycans in cancer 💬
 [1] ESR1 💬 D02367 💬 Desogestrel [1] 230 💬
13 Proteoglycans in cancer 💬
 [1] ESR1 💬 D11513 💬 Estetrol [1] 53 💬
14 Proteoglycans in cancer 💬
 [1] ESR1 💬 D11514 💬 Estetrol [1] 53 💬
15 Proteoglycans in cancer 💬
 [1] ESR1 💬 D00105 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
16 Proteoglycans in cancer 💬
 [1] ESR1 💬 D01413 💬 Estradiol valerate [1] 65 💬
17 Proteoglycans in cancer 💬
 [1] ESR1 💬 D00185 💬 Estriol [2] 13, 227 💬
18 Proteoglycans in cancer 💬
 [1] ESR1 💬 D01986 💬 Estriol [2] 13, 227 💬
19 Proteoglycans in cancer 💬
 [1] ESR1 💬 D00554 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
20 Proteoglycans in cancer 💬
 [1] ESR1 💬 D01161 💬 Fulvestrant [2] 49, 86 💬
21 Proteoglycans in cancer 💬
 [1] ESR1 💬 D00575 💬 Mestranol [2] 46, 49 💬
22 Proteoglycans in cancer 💬
 [1] ESR1 💬 D08409 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
23 Proteoglycans in cancer 💬
 [1] ESR1 💬 D08465 💬 Raloxifene [1] 46 💬
24 Proteoglycans in cancer 💬
 [1] ESR1 💬 D08559 💬 Tamoxifen [3]  2 , 113, 227 💬
25 Proteoglycans in cancer 💬
 [1] FGFR1 💬 D11589 💬 Infigratinib [1] 276 💬
26 Proteoglycans in cancer 💬
 [2] FGFR1, KDR 💬 D10481 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
27 Proteoglycans in cancer 💬
 [1] IGF1R 💬 D09925 💬 Linsitinib [1] 232 💬
28 Proteoglycans in cancer 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
29 Proteoglycans in cancer 💬
 [1] IGF1R 💬 D09680 💬 Teprotumumab [1] 51 💬
30 Proteoglycans in cancer 💬
 [1] IL12B 💬 D09214 💬 Ustekinumab [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
31 Proteoglycans in cancer 💬
 [1] KDR 💬 D03218 💬 Axitinib [1] 34 💬
32 Proteoglycans in cancer 💬
 [1] KDR 💬 D08881 💬 Cediranib [1] 34 💬
33 Proteoglycans in cancer 💬
 [1] KDR 💬 D08552 💬 Sunitinib [2] 28, 34 💬
34 Proteoglycans in cancer 💬
 [2] KDR, MET 💬 D10062 💬 Cabozantinib [1] 34 💬
35 Proteoglycans in cancer 💬
 [2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
36 Proteoglycans in cancer 💬
 [2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
37 Proteoglycans in cancer 💬
 [2] MAP2K1, MAP2K2 💬 D11675 💬 Mirdametinib [1] 34 💬
38 Proteoglycans in cancer 💬
 [2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
39 Proteoglycans in cancer 💬
 [2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
40 Proteoglycans in cancer 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
41 Proteoglycans in cancer 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
42 Proteoglycans in cancer 💬
 [1] MTOR 💬 D02714 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
43 Proteoglycans in cancer 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
44 Proteoglycans in cancer 💬
 [1] MTOR 💬 D06068 💬 Temsirolimus [1] 13 💬
45 Proteoglycans in cancer 💬
 [1] PIK3CA 💬 D11011 💬 Alpelisib [1] 138 💬
46 Proteoglycans in cancer 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
47 Proteoglycans in cancer 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
48 Proteoglycans in cancer 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
49 Proteoglycans in cancer 💬
 [2] ROCK1, ROCK2 💬 D07941 💬 Fasudil [4]  2 ,  5 ,  7 , 51 💬
50 Proteoglycans in cancer 💬
 [1] ROCK2 💬 D11815 💬 Belumosudil [2] 51, 85 💬
51 Proteoglycans in cancer 💬
 [1] SMO 💬 D10671 💬 Taladegib [1] 85 💬
52 Proteoglycans in cancer 💬
 [1] SMO 💬 D09992 💬 Vismodegib [1] 85 💬
53 Proteoglycans in cancer 💬
 [1] SRC 💬 D03252 💬 Bosutinib [2]  2 , 67 💬
54 Proteoglycans in cancer 💬
 [1] SRC 💬 D03658 💬 Dasatinib [2] 51, 85 💬
55 Proteoglycans in cancer 💬
 [1] SRC 💬 D06414 💬 Dasatinib [2] 51, 85 💬
56 Proteoglycans in cancer 💬
 [1] SRC 💬 D09664 💬 Saracatinib [3]  6 , 89, 272 💬
57 Proteoglycans in cancer 💬
 [2] TGFB1, TGFB2 💬 D09620 💬 Fresolimumab [3] 51, 85, 222 💬
58 Proteoglycans in cancer 💬
 [1] TNF 💬 D02597 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
59 Proteoglycans in cancer 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
60 Proteoglycans in cancer 💬
 [1] TNF 💬 D00742 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
61 Proteoglycans in cancer 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
62 Proteoglycans in cancer 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
63 Proteoglycans in cancer 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
64 Proteoglycans in cancer 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
65 Proteoglycans in cancer 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
66 Proteoglycans in cancer 💬
 [1] TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
67 Proteoglycans in cancer 💬
 [1] TNF 💬 D08976 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
68 Proteoglycans in cancer 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
69 Proteoglycans in cancer 💬
 [1] VEGFA 💬 D09574 💬 Aflibercept [2] 90, 166 💬
70 Proteoglycans in cancer 💬
 [1] VEGFA 💬 D06409 💬 Bevacizumab [6] 13, 34, 85, 87, 227, 280 💬
71 Proteoglycans in cancer 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬