Flumazenil ( DrugBank: Flumazenil )

5 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
6	パーキンソン病	3
13	多発性硬化症／視神経脊髄炎	3
17	多系統萎縮症	1
18	脊髄小脳変性症（多系統萎縮症を除く。）	1
206	脆弱Ｘ症候群	2

6. パーキンソン病

臨床試験数 : 2,307 / 薬物数 : 2,007 - (DrugBank : 349) / 標的遺伝子数 : 188 - 標的パスウェイ数 : 199

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03462641 (ClinicalTrials.gov)	March 9, 2018	6/3/2018	Modulation of GABA-A Receptors in Parkinson Disease-Flumazenil Arm	Modulation of GABA-A Receptors and Axial Motor Impairments in Parkinson Disease-Flumazenil Arm	Parkinson Disease	Drug: Flumazenil;Drug: Placebo	University of Michigan	National Institute of Neurological Disorders and Stroke (NINDS)	Completed	50 Years	99 Years	All	26	Phase 1/Phase 2	United States
2	NCT03440112 (ClinicalTrials.gov)	January 29, 2018	26/1/2018	Modulation of GABA-A Receptors in Parkinson Disease-Transdermal Flumazenil Arm	Modulation of GABA-A Receptors and Axial Motor Impairments in Parkinson	Parkinson Disease	Drug: Clarithromycin (Not used as of 4/2020);Drug: Placebo (Not used as of 4/2020);Drug: Transdermal flumazenil (Added 4/2020);Drug: Placebo (Added 4/2020)	Nicolaas Bohnen, MD, PhD	National Institute of Neurological Disorders and Stroke (NINDS)	Recruiting	50 Years	N/A	All	30	Phase 1/Phase 2	United States
3	JPRN-UMIN000011111	2013/07/16	15/07/2013	Spinal blood flow and metabolism in neurological diseases	Spinal blood flow and metabolism in neurological diseases - Spinal blood flow and metabolism in neurological diseases	motor neuron disease including ALS, multiple sclerosis, stroke, Parkinson disease, spinocerebellar degeneration, multiple system atrophy	PET scan study with 11C-flumazenil PET scan study with 18F- FDG PET scan study with 15O-H2O	Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences	NULL	Recruiting	20years-old	Not applicable	Male and Female	70	Not applicable	Japan

13. 多発性硬化症／視神経脊髄炎

臨床試験数 : 3,340 / 薬物数 : 2,163 - (DrugBank : 383) / 標的遺伝子数 : 241 - 標的パスウェイ数 : 238

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2017-002636-16-NL (EUCTR)	09/10/2017	09/08/2017	Understanding problems with attention, memory and concentration in persons with multiple sclerosis	Cognitive impairment and functional reorganization in multiple sclerosis: The role of GABA and glutamate - GABA and glutamate in cognitive impairment in MS	Multiple Sclerosis (MS). And specifically cognitive problems in MS.;Therapeutic area: Diseases [C] - Nervous System Diseases [C10]	Product Name: [11C]flumazenil	VU University medical center Amsterdam	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes		Phase 4	Netherlands
2	JPRN-UMIN000011111	2013/07/16	15/07/2013	Spinal blood flow and metabolism in neurological diseases	Spinal blood flow and metabolism in neurological diseases - Spinal blood flow and metabolism in neurological diseases	motor neuron disease including ALS, multiple sclerosis, stroke, Parkinson disease, spinocerebellar degeneration, multiple system atrophy	PET scan study with 11C-flumazenil PET scan study with 18F- FDG PET scan study with 15O-H2O	Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences	NULL	Recruiting	20years-old	Not applicable	Male and Female	70	Not applicable	Japan
3	NCT01651520 (ClinicalTrials.gov)	June 2013	25/7/2012	Prognosis Value of the Neuronal Damage in Early Multiple Sclerosis	Prognosis Value of the Neuronal Damage Detected by Positrons Emission Tomography (PET) With 11C-Flumazenil in Early Multiple Sclerosis.	Multiple Sclerosis	Drug: PET with 11C-Flumazenil	Assistance Publique - Hôpitaux de Paris	NULL	Active, not recruiting	18 Years	55 Years	All	60	N/A	France

17. 多系統萎縮症

臨床試験数 : 119 / 薬物数 : 138 - (DrugBank : 44) / 標的遺伝子数 : 59 - 標的パスウェイ数 : 111

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-UMIN000011111	2013/07/16	15/07/2013	Spinal blood flow and metabolism in neurological diseases	Spinal blood flow and metabolism in neurological diseases - Spinal blood flow and metabolism in neurological diseases	motor neuron disease including ALS, multiple sclerosis, stroke, Parkinson disease, spinocerebellar degeneration, multiple system atrophy	PET scan study with 11C-flumazenil PET scan study with 18F- FDG PET scan study with 15O-H2O	Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences	NULL	Recruiting	20years-old	Not applicable	Male and Female	70	Not applicable	Japan

18. 脊髄小脳変性症（多系統萎縮症を除く。）

臨床試験数 : 76 / 薬物数 : 98 - (DrugBank : 31) / 標的遺伝子数 : 44 - 標的パスウェイ数 : 65

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-UMIN000011111	2013/07/16	15/07/2013	Spinal blood flow and metabolism in neurological diseases	Spinal blood flow and metabolism in neurological diseases - Spinal blood flow and metabolism in neurological diseases	motor neuron disease including ALS, multiple sclerosis, stroke, Parkinson disease, spinocerebellar degeneration, multiple system atrophy	PET scan study with 11C-flumazenil PET scan study with 18F- FDG PET scan study with 15O-H2O	Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences	NULL	Recruiting	20years-old	Not applicable	Male and Female	70	Not applicable	Japan

206. 脆弱Ｘ症候群

臨床試験数 : 108 / 薬物数 : 91 - (DrugBank : 36) / 標的遺伝子数 : 52 - 標的パスウェイ数 : 77

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04308954 (ClinicalTrials.gov)	November 1, 2016	11/3/2020	Neuroimaging GABA Physiology in Fragile X Syndrome	Cross-Species Multi-Modal Neuroimaging to Investigate GABA Physiology in Fragile X Syndrome	Fragile X Syndrome (FXS);Idiopathic Intellectual Developmental Disorder (IDD)	Drug: [18F]flumazenil	Stanford University	NULL	Terminated	18 Years	30 Years	Male	17	Phase 1	United States
2	EUCTR2008-003287-18-BE (EUCTR)	17/09/2008	03/09/2008	Functional consequences of decreased RNA expression of certain GABA(A) receptor subunits in fragile X patients using Positron Emission Tomography and [11C]flumazenil. - PET-FRAX-GABA	Functional consequences of decreased RNA expression of certain GABA(A) receptor subunits in fragile X patients using Positron Emission Tomography and [11C]flumazenil. - PET-FRAX-GABA	Fragile X syndrome is the most common form of inherited mental retardation with a prevalence of 1/4000 males and 1/6000 females. Patients are characterized by a mild to severe form of cognitive impairment and light dysmorphic features. Autism-like behaviour, hyperactivity and epilepsy can also be associated with the disease. On the molecular level the disease is caused by a dynamic mutation of a CGG repeat in the 5' UTR of the FMR1 gene.	Product Name: 11C-flumazenil	University Antwerp	University Hospital Leuven gasthuisberg	Authorised-recruitment may be ongoing or finished			Female: no Male: yes			Belgium

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